Výsledky vyhledávání - "Protein phosphatase-2A"

Akademický článek

Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems

Autor: Zoltán Kónya, Bálint Bécsi, Andrea Kiss, Dániel Horváth, Mária Raics, Katalin E. Kövér, Beáta Lontay, Ferenc Erdődi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 500-509 (2019)

Several ellagitannins inhibited the activity of protein phosphatase-1 (PP1) and -2 A (PP2A) catalytic subunits (PP1c and PP2Ac) with preferential suppression of PP1c over PP2Ac. The inhibitory potency for PP1c followed the order of tellimagrandin I >

Externí odkaz: https://doaj.org/article/1ebea239b38c40f89067b205d3226b25

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Akademický článek

Epigallocatechine-3-gallate Inhibits the Adipogenesis of Human Mesenchymal Stem Cells via the Regulation of Protein Phosphatase-2A and Myosin Phosphatase

Autor: Bálint Bécsi, Zoltán Kónya, Anita Boratkó, Katalin Kovács, Ferenc Erdődi

Publikováno v: Cells, Vol 11, Iss 10, p 1704 (2022)

Epigallocatechin-3-gallate (EGCG) has widespread effects on adipocyte development. However, the molecular mechanisms of EGCG are not fully understood. We investigate the adipogenic differentiation of human-derived mesenchymal stem cells, including li

Externí odkaz: https://doaj.org/article/e144a3af52f14707846924b15de3fc28

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Akademický článek

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Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants

Autor: Kyle J. Burghardt, Berhane Seyoum, Aktham Mestareehi, Abdullah Mallisho, Zaher Msallaty, Zhengping Yi, Anjaneyulu Kowluru, Xiangmin Zhang

Publikováno v: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2021 (2021)

Context. Skeletal muscle insulin resistance is one of the primary contributors of type 2 diabetes (T2D). Metformin is the first-line drug for the treatment of T2D. The primary effects of metformin include decreasing glucose production in the liver an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3e7c1cbab5ee1c77ca2db906b1a7b6
https://doi.org/10.1155/2021/9979234

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Epigallocatechine-3-gallate Inhibits the Adipogenesis of Human Mesenchymal Stem Cells via the Regulation of Protein Phosphatase-2A and Myosin Phosphatase

Autor: Erdődi, Bálint Bécsi, Zoltán Kónya, Anita Boratkó, Katalin Kovács, Ferenc

Publikováno v: Cells; Volume 11; Issue 10; Pages: 1704

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::d31c698b47d48963427802319f07a5e1

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Akademický článek

Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A

Autor: Ling Li, Zhirong Liu, Juanfang Liu, Xuhui Tai, Xinghua Hu, Xuedong Liu, Zhongliang Wu, Guangyun Zhang, Ming Shi, Gang Zhao

Publikováno v: Neurobiology of Disease, Vol 54, Iss , Pp 320-328 (2013)

Neurofibrillary tangles are aggregates of hyperphosphorylated tau that are one of the pathological hallmarks of Alzheimer's disease (AD). Tau phosphorylation is regulated by a balance of kinase and phosphatase activities. Our previous study has demon

Externí odkaz: https://doaj.org/article/553f9f148f0d4b44a4306170fce0b284

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Akademický článek

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WHY HAS THE PAPER ENTITLED 'GREATWALL-PHOSPHORYLATED Α-ENDOSULFINE IS BOTH AN INHIBITOR AND A SUBSTRATE OF PP2A-B55 HETEROTRIMERS' BY WILLIAMS, M.C. ET AL. THAT WAS PUBLISHED IN ELIFE [WILLIAMS, B.C., FILTER, J.J., BLAKE-HODEK, K.A., FUDA, N.J., SHALLOWAY, D. AND GOLDBERG, M.L. (2014) ELIFE, DOI: 10.7554/ELIFE.01695 ] NOT BEEN RETRACTED?

Autor: Tung, H.Y. Lim

The paper entitled "Greatwall-phosphorylated α-Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers" authored by Williams, B.C. et al. [Williams, B.C., Filter, J.J., Blake-Hodek, K.A., Fuda, N.J., Shalloway, D. and Goldberg, M.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a00e66906aeab9801756c13d652e87

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Akademický článek

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Autor: Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun

Publikováno v: Journal of Lipid Research, Vol 45, Iss 3, Pp 496-506 (2004)

The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined. d-erythro-C6 ceramide activated the catalytic

Externí odkaz: https://doaj.org/article/a6aa04bdad2846efa906c980b63ec96c

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