Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Protein kinase N"'
Akademický článek
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Autor:
Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 440-448 (2016)
In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality
Externí odkaz:
https://doaj.org/article/96edc553b94e4ce0be7befee57ac296c
Akademický článek
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Akademický článek
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Autor:
Katlin B. Massirer, Lewis E. Pennicott, Fiona Scott, Jonathan M. Elkins, Simon E. Ward, Tristan Reuillon, A.M. Fala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Kinases are signalling proteins which have proven to be successful targets for the treatment of a variety of diseases, predominantly in cancers. However, only a small proportion of kinases (
Kinases are signalling proteins which have proven to be successful targets for the treatment of a variety of diseases, predominantly in cancers. However, only a small proportion of kinases (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1561d0a57fd94895c128a26cfe5805
https://doi.org/10.1016/j.bmcl.2020.127040
https://doi.org/10.1016/j.bmcl.2020.127040
Akademický článek
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Autor:
Stefan Offermanns, Hideki Ishii, Mutsuki Amano, Tomonari Hamaguchi, Yasuko K Bando, Atsushi Enomoto, Mikito Takefuji, Yuuki Shimizu, Katsuhiro Kato, Noriyuki Ouchi, Toyoaki Murohara, Shunsuke Eguchi, Koji Ohashi, Nina Wettschureck, Takuma Tsuda, Kazumasa Unno, Yoshimitsu Yura, Tatsuya Yoshida, Kozo Kaibuchi, Sohta Ishihama, Takahiro Okumura, Teruhiro Sakaguchi, Yu Mori
Publikováno v:
Circulation. 140(21)
Background: Heart failure is a complex syndrome that results from structural or functional impairment of ventricular filling or blood ejection. Protein phosphorylation is a major and essential intracellular mechanism that mediates various cellular pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565a4a5b4f4ad9b4607aaac0c3ef292f
https://pubmed.ncbi.nlm.nih.gov/31564129
https://pubmed.ncbi.nlm.nih.gov/31564129
Autor:
Marrocco, Valeria, Bogomolovas, Julius, Ehler, Elisabeth, dos Remedios, Cristobal G., Yu, Jiayu, Gao, Chen, Lange, Stephan
Publikováno v:
Journal of Molecular and Cellular Cardiology
The protein kinase C (PKC) and closely related protein kinase N (PKN) families of serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC subfamily of protein kinases that also include the cAMP dependent protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5fc668d19aacee2daa1d9755dd7659d6
https://pubmed.ncbi.nlm.nih.gov/30742812
https://pubmed.ncbi.nlm.nih.gov/30742812
Autor:
Stephan Grant, Ben Bolaños, Alexei Brooun, Sergei Timofeevski, Anke Klippel, Keziban Unsal-Kacmaz, Matthew D. Falk, Wei Liu
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 34, Iss 2, p e00097 (2014)
Bioscience Reports, Vol 34, Iss 2, p e00097 (2014)
The PKN (protein kinase N) family of Ser/Thr protein kinases regulates a diverse set of cellular functions, such as cell migration and cytoskeletal organization. Inhibition of tumour PKN activity has been explored as an oncology therapeutic approach,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9296fbb67d23c619416a2b8cfbef2774
https://doi.org/10.1042/bsr20140010
https://doi.org/10.1042/bsr20140010
Autor:
Quétier I, Jj, Marshall, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Jt, Worrall, Baskaran P, Rajeeve V, Howell M, Aj, Copp, Stamp G, Rosewell I, Cutillas P, Holger Gerhardt, Pj, Parker, Aj, Cameron
Publikováno v:
Cell Reports
Cell Reports, Vol 14, Iss 3, Pp 440-448 (2016)
Quétier, I, Marshall, J J T, Spencer-Dene, B, Lachmann, S, Casamassima, A, Franco, C, Escuin, S, Worrall, J T, Baskaran, P, Rajeeve, V, Howell, M, Copp, A J, Stamp, G, Rosewell, I, Cutillas, P, Gerhardt, H, Parker, P J & Cameron, A J M 2016, ' Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion ', Cell Reports, vol. 14, no. 3, pp. 440-448 . https://doi.org/10.1016/j.celrep.2015.12.049
Europe PubMed Central
Cell Reports, Vol 14, Iss 3, Pp 440-448 (2016)
Quétier, I, Marshall, J J T, Spencer-Dene, B, Lachmann, S, Casamassima, A, Franco, C, Escuin, S, Worrall, J T, Baskaran, P, Rajeeve, V, Howell, M, Copp, A J, Stamp, G, Rosewell, I, Cutillas, P, Gerhardt, H, Parker, P J & Cameron, A J M 2016, ' Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion ', Cell Reports, vol. 14, no. 3, pp. 440-448 . https://doi.org/10.1016/j.celrep.2015.12.049
Europe PubMed Central
Summary In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::27c8650d20abadd56d4df9fa631e90af