Zobrazeno 1 - 10
of 1 896
pro vyhledávání: '"Protein homeostasis"'
Publikováno v:
MedComm, Vol 5, Iss 10, Pp n/a-n/a (2024)
Abstract Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction. By precisely regulating protein quality and quant
Externí odkaz:
https://doaj.org/article/9aa330ec6819416f8393684e1f74d39e
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6423-6439 (2024)
Neurodegeneration is becoming one of the leading causes of death worldwide as the population expands and grows older. There is a growing desire to understand the mechanisms behind prion proteins as well as the prion-like proteins that make up neurode
Externí odkaz:
https://doaj.org/article/99ba7402254f47f7bacc8058bd737e6b
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
Titanium dioxide nanoparticles (TiO2-NPs) released into the environment is becoming more prevalent due to their increased usage, marine TiO2-NPs contamination is escalating concerns in coastal areas. To understand the potential impact of TiO2-NPs on
Externí odkaz:
https://doaj.org/article/726b7bb9f569432992a1d25554e9e05b
Autor:
Virginie Vignard, Alban-Elouen Baruteau, Bérénice Toutain, Sandra Mercier, Bertrand Isidor, Richard Redon, Jean-Jacques Schott, Sébastien Küry, Stéphane Bézieau, Anne H. Monsoro-Burq, Frédéric Ebstein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Neurodevelopmental proteasomopathies constitute a recently defined class of rare Mendelian disorders, arising from genomic alterations in proteasome-related genes. These alterations result in the dysfunction of proteasomes, which are multi-subunit pr
Externí odkaz:
https://doaj.org/article/8ec98747cd9e4fccb622ac05f5cea598
Autor:
Renata T. Da Costa, Pedro Urquiza, Matheus M. Perez, YunGuang Du, Mei Li Khong, Haiyan Zheng, Mariona Guitart-Mampel, Pia A. Elustondo, Ernest R. Scoma, Vedangi Hambardikar, Beatrix Ueberheide, Julian A. Tanner, Alejandro Cohen, Evgeny V. Pavlov, Cole M. Haynes, Maria E. Solesio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle. However, the precise molecular composition of these mechanisms remains unclear. Our data show that
Externí odkaz:
https://doaj.org/article/88ee7d20f5ac4d03baa5fa1375c6926b
Autor:
Hui‐Jie Zhang, Ben‐Hui Wang, Xiang Wang, Chun‐Ping Huang, Si‐Man Xu, Jia‐Li Wang, Tian‐E Huang, Wan‐Li Xiao, Xiao‐Li Tian, Xin‐Qiang Lan, Qi‐Quan Wang, Yang Xiang
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 173-188 (2024)
Abstract Background Handelin is a bioactive compound from Chrysanthemum indicum L. that improves motor function and muscle integrity during aging in Caenorhabditis elegans. This study aimed to further evaluate the protective effects and molecular mec
Externí odkaz:
https://doaj.org/article/1c0f560da4bb418e8e19c5e7e54403fb
Autor:
Michele Perni, Benedetta Mannini
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1324 (2024)
Proteinopathies involve the abnormal accumulation of specific proteins. Maintaining the balance of the proteome is a finely regulated process managed by a complex network of cellular machinery responsible for protein synthesis, folding, and degradati
Externí odkaz:
https://doaj.org/article/a93f50660b4d45dab8076f6854bbf70f
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Currently, over 220 (mostly missense)
Externí odkaz:
https://doaj.org/article/0ef503364ff148a8a1fbbbf902661138
Autor:
Amélie Ducloy, Marianne Azzopardi, Caroline Ivsic, Gwendal Cueff, Delphine Sourdeval, Delphine Charif, Jean-Luc Cacas
Publikováno v:
Data in Brief, Vol 53, Iss , Pp 110243- (2024)
The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This RNA sequencing (RNA-seq)
Externí odkaz:
https://doaj.org/article/ad3df57fe627413aad79430be7d69f5b
Publikováno v:
Cells, Vol 13, Iss 17, p 1449 (2024)
Background: Intracellular tracking is commonly used in trafficking research. Until today, the respective techniques have remained complex, and complicated, mostly transgenic target protein changes are necessary, often requiring expensive equipment an
Externí odkaz:
https://doaj.org/article/e96a6d49fe0249d28f2aa005dcc7ec6f