Zobrazeno 1 - 10
of 8 792
pro vyhledávání: '"Protein function"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The identification of protein binding residues helps to understand their biological processes as protein function is often defined through ligand binding, such as to other proteins, small molecules, ions, or nucleotides. Methods predicting b
Externí odkaz:
https://doaj.org/article/2b3dcdd6452b40dbbaff9693ba42b48b
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background In last two decades, the use of high-throughput sequencing technologies has accelerated the pace of discovery of proteins. However, due to the time and resource limitations of rigorous experimental functional characterization, the
Externí odkaz:
https://doaj.org/article/a5dcf5f0ad87463f95bb0a879529be25
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background The advent of high-throughput technologies has led to an exponential increase in uncharacterized bacterial protein sequences, surpassing the capacity of manual curation. A large number of bacterial protein sequences remain unannot
Externí odkaz:
https://doaj.org/article/a3fb60e039b548deb251de7e105b8bb1
Publikováno v:
Medical Review, Vol 3, Iss 6, Pp 487-510 (2023)
Proteins function as integral actors in essential life processes, rendering the realm of protein research a fundamental domain that possesses the potential to propel advancements in pharmaceuticals and disease investigation. Within the context of pro
Externí odkaz:
https://doaj.org/article/7d12b58c38a141bbb00c614184bf9d7f
Publikováno v:
Medicine in Omics, Vol 12, Iss , Pp 100040- (2024)
Clostridium botulinum strain Hall produces potent botulinum neurotoxin type A1, which causes food-borne, infant, and wound botulism in humans. Antibiotics and botulinum antitoxins can control growth and prevent botulinum toxicity. However, limited in
Externí odkaz:
https://doaj.org/article/bff25611fff74b46b9d954afacf1b70c
Autor:
Victoria I. Bunik
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/798316d8703b4603a7127ff76953728f
Autor:
Jin-Min Pan, Yu Liang, Ke-Cheng Zhu, Hua-Yang Guo, Bao-Suo Liu, Nan Zhang, Lin Xian, Teng-Fei Zhu, Dian-Chang Zhang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Galectins (Gals) are a type of S-type lectin that are widespread and evolutionarily conserved among metazoans, and can act as pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs). In this study, 10 Gals (To
Externí odkaz:
https://doaj.org/article/7e8e9f93ac94485e9d2d7ab58061d3c1
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32951- (2024)
The use of anti-inflammatory peptides (AIPs) as an alternative therapeutic approach for inflammatory diseases holds great research significance. Due to the high cost and difficulty in identifying AIPs with experimental methods, the discovery and desi
Externí odkaz:
https://doaj.org/article/883add5c14234fe588634600e765c392
Autor:
Lingyan Zheng, Shuiyang Shi, Mingkun Lu, Pan Fang, Ziqi Pan, Hongning Zhang, Zhimeng Zhou, Hanyu Zhang, Minjie Mou, Shijie Huang, Lin Tao, Weiqi Xia, Honglin Li, Zhenyu Zeng, Shun Zhang, Yuzong Chen, Zhaorong Li, Feng Zhu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Protein function annotation has been one of the longstanding issues in biological sciences, and various computational methods have been developed. However, the existing methods suffer from a serious long-tail problem, with a large number of
Externí odkaz:
https://doaj.org/article/e654abfe23f9473fa0b7b7f2b439d1d8
Autor:
David Stein, Meltem Ece Kars, Yiming Wu, Çiğdem Sevim Bayrak, Peter D. Stenson, David N. Cooper, Avner Schlessinger, Yuval Itan
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Gain-of-function (GOF) variants give rise to increased/novel protein functions whereas loss-of-function (LOF) variants lead to diminished protein function. Experimental approaches for identifying GOF and LOF are generally slow and costly, wh
Externí odkaz:
https://doaj.org/article/e13ec2e645a64a879f6a689a901c55ea