Zobrazeno 1 - 10
of 2 913
pro vyhledávání: '"Protein delivery"'
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-25 (2024)
Abstract Protein drugs are of great importance in maintaining the normal functioning of living organisms. Indeed, they have been instrumental in combating tumors and genetic diseases for decades. Among these pharmaceutical agents, those that target i
Externí odkaz:
https://doaj.org/article/88fbb6c07b584e2cade3600d134fcc54
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 3, Pp 75-84 (2024)
Introduction. Dissolving polymeric microneedles are attractive drug delivery system especially for vaccine delivery. Still there are a lot of obstacles in developing scalable manufacturing process of them.Aim. To develop a scalable manufacturing proc
Externí odkaz:
https://doaj.org/article/8524785c76b7438899d0e89f304c03a9
Publikováno v:
Проблемы особо опасных инфекций, Vol 0, Iss 2, Pp 51-61 (2024)
Oral vaccines are drawing more attention due to their ease of administration, lesser invasiveness, and greater safety in general. The review discusses the benefits of oral vaccination in stimulating humoral and cellular immune responses at the system
Externí odkaz:
https://doaj.org/article/a55f1aac5ac3410ab764c0aaa47fe941
Autor:
Zhen Li, Junyue Xing, Xiaohan Ma, Wanjun Zhang, Chuan Wang, Yingying Wang, Xinkun Qi, Yanhui Liu, Dongdong Jian, Xiaolei Cheng, Yanjie Zhu, Chao Shi, Yongjun Guo, Huan Zhao, Wei Jiang, Hao Tang
Publikováno v:
Bioactive Materials, Vol 37, Iss , Pp 517-532 (2024)
The cardiotoxicity caused by Dox chemotherapy represents a significant limitation to its clinical application and is a major cause of late death in patients undergoing chemotherapy. Currently, there are no effective treatments available. Our analysis
Externí odkaz:
https://doaj.org/article/c993838d68c345d49e86008377675a04
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Delivery of active protein especially enzyme is one of the major therapeutic challenge. Replacing or substituted invalid/improper acting protein offer fast and effective treatment of disease. Herein, we describe the synthesis and properties
Externí odkaz:
https://doaj.org/article/f4b7580a7ee84de2abd4bdd35f1c04c5
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 4429-4449 (2024)
Yun Liu,1,2 Timo Hamm,3 Thomas Ralf Eichinger,3 Walter Kamm,3 Heike Andrea Wieland,3 Brigitta Loretz,1 Anna KH Hirsch,2,4 Sangeun Lee,1,2 Claus-Michael Lehr1,2 1Department of Drug Delivery Across Biological Barriers, Helmholtz Institute for Pharmaceu
Externí odkaz:
https://doaj.org/article/5eb5aa7e7f884779beae81ec43210637
Publikováno v:
Exploration, Vol 4, Iss 3, Pp n/a-n/a (2024)
Abstract Protein‐based drugs have shown unique advantages to treat various diseases in recent years. However, most protein therapeutics in clinical use are limited to extracellular targets with low delivery efficiency. To realize targeted protein d
Externí odkaz:
https://doaj.org/article/7ee1e3575dac487890910a967d6d693a
Autor:
Weiting Zhang, Karl Petri, Junyan Ma, Hyunho Lee, Chia-Lun Tsai, J Keith Joung, Jing-Ruey Joanna Yeh
Publikováno v:
eLife, Vol 12 (2024)
CRISPR prime editing (PE) requires a Cas9 nickase-reverse transcriptase fusion protein (known as PE2) and a prime editing guide RNA (pegRNA), an extended version of a standard guide RNA (gRNA) that both specifies the intended target genomic sequence
Externí odkaz:
https://doaj.org/article/ad99b0e410504a6dbdf94fc1701017e7
Autor:
Yuqiong Xia, Keyun Wu, Chang Liu, Xuejuan Zhao, Jun Wang, Jianxia Cao, Zhaoxu Chen, Minchao Fang, Jie Yu, Cheng Zhu, Xianghan Zhang, Zhongliang Wang
Publikováno v:
Advanced Science, Vol 11, Iss 10, Pp n/a-n/a (2024)
Abstract Despite the potential of protein therapeutics, the cytosolic delivery of proteins with high efficiency and bioactivity remains a significant challenge owing to exocytosis and lysosomal degradation after endocytosis. Therefore, it is importan
Externí odkaz:
https://doaj.org/article/0b2a4eb2c8814a25bb6f52e805d13e51
Publikováno v:
Polymers, Vol 16, Iss 13, p 1871 (2024)
Polyion complex (PIC) nanoparticles, including PIC micelles and PICsomes, are typically composed of poly(ethylene glycol) block copolymers coupled with oppositely charged polyelectrolytes or therapeutic agents via electrostatic interaction. Due to a
Externí odkaz:
https://doaj.org/article/a8ea0946250b4c74b8283c34e1f36b78