Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Protein deacetylase activity"'
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-18 (2020)
Molecular Brain
Molecular Brain
Sleep deprivation is a global health problem adversely affecting health as well as causing decrements in learning and performance. Sleep deprivation induces significant changes in gene transcription in many brain regions, with the hippocampus particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4882e38566e3799764040a548602db3
https://doaj.org/article/04ee3daa817a47ffbb396842a289e45e
https://doaj.org/article/04ee3daa817a47ffbb396842a289e45e
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Hypertension is characterized by endothelial dysfunction, vascular remodeling, and rearrangement of the extracellular matrix. Besides, the pathogenesis of hypertension is closely related to excess generation of reactive oxygen species (ROS). Nicotina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db65c2ba17fa39bdcbaa9f5d74e7fc7
https://pubmed.ncbi.nlm.nih.gov/33488923
https://pubmed.ncbi.nlm.nih.gov/33488923
Autor:
Takayuki Inoue, Toru Kusakabe, Akira Shimatsu, Ryuji Ohue-Kitano, Masashi Tanaka, Kazuya Muranaka, Koji Hasegawa, Hiromichi Wada, Shinya Masuda, Hajime Yamakage, Noriko Satoh-Asahara
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:552-560
Obesity and diabetes are known risk factors for dementia, and it is speculated that chronic neuroinflammation contributes to this increased risk. Microglia are brain-resident immune cells modulating the neuroinflammatory state. Eicosapentaenoic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc62b2193b0713767bb6e0ba9e312742
https://doi.org/10.1016/j.bbalip.2017.02.010
https://doi.org/10.1016/j.bbalip.2017.02.010
Publikováno v:
Experimental Parasitology. 169:28-33
Sir2 family proteins are highly conserved and catalyze Nicotinamide Adenine Dinucleotide (NAD(+))-dependent protein deacetylation reaction that regulates multiple cellular processes. Little is known about Sir2 family proteins in Giardia. In this rese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bf9f26ede942126ccfb5dc29881673
https://doi.org/10.1016/j.exppara.2016.07.002
https://doi.org/10.1016/j.exppara.2016.07.002
Autor:
Malcolm F. White, Stephen P. Jackson, Catherine H. Botting, Benjamin N. Wardleworth, Stephen D. Bell
The conserved Sir2 family of proteins has protein deacetylase activity that is dependent on NAD (the oxidized form of nicotinamide adenine dinucleotide). Although histones are one likely target for the enzymatic activity of eukaryotic Sir2 proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8872931c14784582ec0b56b6a3a61b4
https://ora.ox.ac.uk/objects/uuid:275d560d-52e6-4f0d-8a0e-bb3085cb36b1
https://ora.ox.ac.uk/objects/uuid:275d560d-52e6-4f0d-8a0e-bb3085cb36b1
Publikováno v:
Journal of Bacteriology. 191:1749-1755
Acetate is abundant in soil, the natural habitat of the gram-positive bacterium Bacillus subtilis. This short-chain fatty acid accumulates in soil and other environments because it is the product of many fermentative processes (7). Many prokaryotes u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ae20a4ce786df366fad1868aeea805d
https://doi.org/10.1128/jb.01674-08
https://doi.org/10.1128/jb.01674-08
Autor:
Scott G. Holmes, Jason C. Tanny, Danesh Moazed, Mirela Matecic, Merrit Hickman, Kristen Martins-Taylor
Publikováno v:
Genetics. 173:1939-1950
The establishment of transcriptional silencing in yeast requires cell-cycle progression, but the nature of this requirement is unknown. Sir2 is a protein deacetylase that is required for gene silencing in yeast. We have used temperature-sensitive all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783d38818d0d95d600d7b15060758c70
https://doi.org/10.1534/genetics.106.055491
https://doi.org/10.1534/genetics.106.055491
Autor:
Zengxuan Nong, Caroline O'Neil, J. Geoffrey Pickering, Eric van der Veer, Brad L. Urquhart, David J. Freeman
Publikováno v:
Circulation Research. 97:25-34
Conversion of vascular smooth muscle cells (SMCs) from a proliferative state to a nonproliferative, contractile state confers vasomotor function to developing and remodeling blood vessels. Using a maturation-competent human SMC line, we determined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d70b15da03bc4f8653d3a9d7a9a88
https://doi.org/10.1161/01.res.0000173298.38808.27
https://doi.org/10.1161/01.res.0000173298.38808.27
Publikováno v:
Journal of Biological Chemistry. 280:21313-21320
Members of the Sir2 family of NAD-dependent protein deacetylases regulate diverse cellular processes including aging, gene silencing, and cellular differentiation. Here, we report that the distant mammalian Sir2 homolog SIRT6 is a broadly expressed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1801e3269cb6f8cf53f362cbdd0be39f
https://doi.org/10.1074/jbc.m413296200
https://doi.org/10.1074/jbc.m413296200
Publikováno v:
Journal of Molecular Biology. 340:1005-1012
Post-translational modification of proteins is an efficient way cells use to control the activity of structural proteins, gene expression regulatory proteins, and enzymes. In eukaryotes, the Sir2-dependent system of protein acetylation/deacetylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94d84923ffd2fd36009fd179bf07a01
https://doi.org/10.1016/j.jmb.2004.05.010
https://doi.org/10.1016/j.jmb.2004.05.010