Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Protein Structure Aspects"'
Autor:
Hiroshi Kadokura, Nanshi Harada, Satoshi Yamaki, Naoya Hirai, Ryusuke Tsukuda, Kota Azuma, Yuta Amagai, Daisuke Nakamura, Kota Yanagitani, Hideki Taguchi, Kenji Kohno, Kenji Inaba
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111189- (2024)
Summary: Localization to the endoplasmic reticulum (ER) and subsequent disulfide bond formation are crucial processes governing the biogenesis of secretory pathway proteins in eukaryotes. Hence, comprehending the mechanisms underlying these processes
Externí odkaz:
https://doaj.org/article/b7151bb5f20d4d959a696fff16c75129
Autor:
Rupinder Singh Jandu, Huaxu Yu, Zhiyu Zhao, Hai Tuong Le, Sehyeon Kim, Tao Huan, Franck Duong van Hoa
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109382- (2024)
Summary: Compared to protein–protein and protein–nucleic acid interactions, our knowledge of protein-lipid interactions remains limited. This is primarily due to the inherent insolubility of membrane proteins (MPs) in aqueous solution. The tradit
Externí odkaz:
https://doaj.org/article/7de56b28e5af4d87a2970662656e7d70
Autor:
Benjamin M. Lorton, Christopher Warren, Humaira Ilyas, Prithviraj Nandigrami, Subray Hegde, Sean Cahill, Stephanie M. Lehman, Jeffrey Shabanowitz, Donald F. Hunt, Andras Fiser, David Cowburn, David Shechter
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109458- (2024)
Summary: Histone chaperones–structurally diverse, non-catalytic proteins enriched with acidic intrinsically disordered regions (IDRs)–protect histones from spurious nucleic acid interactions and guide their deposition into and out of nucleosomes.
Externí odkaz:
https://doaj.org/article/308a4f46ac144de8bb1576a4e9c88faf
Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107031- (2023)
Summary: The Ras superfamily of GTPases regulate critical cellular processes by shuttling between GTP-bound ON and GDP-bound OFF states. This switching mechanism is attributed to the conformational changes in two loops, SWI and SWII, upon GTP binding
Externí odkaz:
https://doaj.org/article/422df69e8ea94c1194bb2aed13f9877b
Akademický článek
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Autor:
Alina Tokmakova, Donghwa Kim, Brian Guthrie, Soo-Kyung Kim, William A. Goddard, III, Stephen B. Liggett
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106422- (2023)
Summary: The 25 human bitter taste receptors (TAS2Rs) are expressed on taste and extra-oral cells representing an integrated chemosensory system. The archetypal TAS2R14 is activated by > 150 topographically diverse agonists, raising the question of h
Externí odkaz:
https://doaj.org/article/382ca3127a474918bc78e67811c5bada
Autor:
Hiam R.S. Arruda, Tulio M. Lima, Renata G.F. Alvim, Fernanda B.A. Victorio, Daniel P.B. Abreu, Federico F. Marsili, Karen D. Cruz, Mayra A. Marques, Patricia Sosa-Acosta, Mauricio Quinones-Vega, Jéssica de S. Guedes, Fábio C.S. Nogueira, Jerson L. Silva, Leda R. Castilho, Guilherme A.P. de Oliveira
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105696- (2023)
Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19. Here, we present compar
Externí odkaz:
https://doaj.org/article/082a714a76334ef283c20689581f07d8
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105483- (2022)
Summary: The conjugative pilus expression (Cpx) stress response system can sense cell envelope stressors, such as misfolded proteins, and upregulate proteases to modify or degrade damaged proteins. YihE is a protein kinase implicated in the Cpx syste
Externí odkaz:
https://doaj.org/article/f6f7077e41b24f83882275f16feb21e4
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105069- (2022)
Summary: The post-synaptic density (PSD) is a phase-separated membraneless compartment of proteins including PSD-95 that undergoes morphological alteration in response to synaptic activity. Here, we investigated the interactome of a three-domain supr
Externí odkaz:
https://doaj.org/article/d1d7673496e94f97b27f0f51f2fef54f
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104722- (2022)
Summary: Membrane recognition by viral spike proteins is critical for infection. Here we show the host cell membrane-binding surfaces of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike variants Alpha, Beta, Gamma, Delta, Epsilon, K
Externí odkaz:
https://doaj.org/article/145aab6d8a8d4d62a405b1a5bf7640f6