Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Protein Kinases/metabolism"'
Autor:
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
Publikováno v:
International journal of molecular sciences. 23(24)
Cardiovascular disease is the major cause of death worldwide. The success of medication and other preventive measures introduced in the last century have not yet halted the epidemic of cardiovascular disease. Although the molecular mechanisms of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eec29ff7b17bfff310277aa6446be45
https://doi.org/10.3390/ijms232416139
https://doi.org/10.3390/ijms232416139
Publikováno v:
International Journal of Molecular Sciences. 23(24)
Cardiovascular disease is the major cause of death worldwide. The success of medication and other preventive measures introduced in the last century have not yet halted the epidemic of cardiovascular disease. Although the molecular mechanisms of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::27c1e1dd65c82763109f2379ae53ca10
https://cris.maastrichtuniversity.nl/en/publications/42a02ca8-a66f-47c0-97d0-e98f6c5d130d
https://cris.maastrichtuniversity.nl/en/publications/42a02ca8-a66f-47c0-97d0-e98f6c5d130d
Autor:
Tue W. Kragstrup, Anne Sofie Sørensen, Mads Brüner, Søren Lomholt, Morten A Nielsen, Peter Schafer, Bent Deleuran
Publikováno v:
Kragstrup, T W, Sørensen, A S, Brüner, M, Lomholt, S, Nielsen, M A, Schafer, P & Deleuran, B 2022, ' MAPK activated kinase 2 inhibition shifts the chemokine signature in arthritis synovial fluid mononuclear cells from CXCR3 to CXCR2 ', International Immunopharmacology, vol. 112, 109267, pp. 109267 . https://doi.org/10.1016/j.intimp.2022.109267
Background: The development of novel treatment strategies of immune-mediated inflammatory arthritis (IMIA) is still a clinical unmet need. The mitogen-activated protein kinase (MAPK) pathway is activated by environmental stressors, growth factors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e54ab673193fa638c9316149fb2b88
https://pure.au.dk/portal/da/publications/mapk-activated-kinase-2-inhibition-shifts-the-chemokine-signature-in-arthritis-synovial-fluid-mononuclear-cells-from-cxcr3-to-cxcr2(e2c6ddf7-4075-4520-8be8-3cd04425cc32).html
https://pure.au.dk/portal/da/publications/mapk-activated-kinase-2-inhibition-shifts-the-chemokine-signature-in-arthritis-synovial-fluid-mononuclear-cells-from-cxcr3-to-cxcr2(e2c6ddf7-4075-4520-8be8-3cd04425cc32).html
Autor:
Maria I. Kontaridis, Amy E. Roberts, Lisa Schill, Lisa Schoyer, Beth Stronach, Gregor Andelfinger, Yoko Aoki, Marni E. Axelrad, Annette Bakker, Anton M. Bennett, Alberto Broniscer, Pau Castel, Caitlin A. Chang, Lukas Cyganek, Tirtha K. Das, Jeroen Hertog, Emilia Galperin, Shruti Garg, Bruce D. Gelb, Kristiana Gordon, Tamar Green, Karen W. Gripp, Maxim Itkin, Maija Kiuru, Bruce R. Korf, Jeff R. Livingstone, Alejandro López‐Juárez, Pilar L. Magoulas, Sahar Mansour, Theresa Milner, Elisabeth Parker, Elizabeth I. Pierpont, Kevin Plouffe, Katherine A. Rauen, Suma P. Shankar, Shane B. Smith, David A. Stevenson, Marco Tartaglia, Richard Van, Morgan E. Wagner, Stephanie M. Ware, Martin Zenker
Publikováno v:
American journal of medical genetics. Part A, vol 188, iss 6
Kontaridis, M I, Roberts, A E, Schill, L, Schoyer, L, Stronach, B, Andelfinger, G, Aoki, Y, Axelrad, M E, Bakker, A, Bennett, A M, Broniscer, A, Castel, P, Chang, C A, Cyganek, L, Das, T K, den Hertog, J, Galperin, E, Garg, S, Gelb, B D, Gordon, K, Green, T, Gripp, K W, Itkin, M, Kiuru, M, Korf, B R, Livingstone, J R, López-Juárez, A, Magoulas, P L, Mansour, S, Milner, T, Parker, E, Pierpont, E I, Plouffe, K, Rauen, K A, Shankar, S P, Smith, S B, Stevenson, D A, Tartaglia, M, Van, R, Wagner, M E, Ware, S M & Zenker, M 2022, ' The seventh international RASopathies symposium : Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery ', American Journal of Medical Genetics. Part A . https://doi.org/10.1002/ajmg.a.62716
American Journal of Medical Genetics, Part A, 188(6), 1915-1927. Wiley-Liss Inc.
Kontaridis, M I, Roberts, A E, Schill, L, Schoyer, L, Stronach, B, Andelfinger, G, Aoki, Y, Axelrad, M E, Bakker, A, Bennett, A M, Broniscer, A, Castel, P, Chang, C A, Cyganek, L, Das, T K, den Hertog, J, Galperin, E, Garg, S, Gelb, B D, Gordon, K, Green, T, Gripp, K W, Itkin, M, Kiuru, M, Korf, B R, Livingstone, J R, López-Juárez, A, Magoulas, P L, Mansour, S, Milner, T, Parker, E, Pierpont, E I, Plouffe, K, Rauen, K A, Shankar, S P, Smith, S B, Stevenson, D A, Tartaglia, M, Van, R, Wagner, M E, Ware, S M & Zenker, M 2022, ' The seventh international RASopathies symposium : Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery ', American Journal of Medical Genetics. Part A . https://doi.org/10.1002/ajmg.a.62716
American Journal of Medical Genetics, Part A, 188(6), 1915-1927. Wiley-Liss Inc.
RASopathies are a group of genetic disorders that are caused by genes that affect the canonical Ras/mitogen-activated protein kinase (MAPK) signaling pathway. Despite tremendous progress in understanding the molecular consequences of these genetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66770a599b697c0d77d007bd425f8e74
https://escholarship.org/uc/item/44s997fh
https://escholarship.org/uc/item/44s997fh
Autor:
Satoshi Fujita, Andrea Moretti, Niko Geldner, Alexandre Pfister, Michael Hothorn, Ulrich Hohmann, Benjamin Brandt, Yan Ma, Satohiro Okuda, Verónica G. Doblas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (5), pp.2693-2703. ⟨10.1073/pnas.1911553117⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 5, pp. 2693-2703
Proceedings of the National Academy of Sciences, Vol. 117, No 5 (2020) pp. 2693-2703
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (5), pp.2693-2703. ⟨10.1073/pnas.1911553117⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 5, pp. 2693-2703
Proceedings of the National Academy of Sciences, Vol. 117, No 5 (2020) pp. 2693-2703
Significance Plants have evolved unique membrane receptor kinases with extracellular leucine-rich repeat domains that regulate diverse developmental processes and that form the first layer of the plant immune system. Here it is shown that 2 sequence-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38e2e004a09d73780577563c8337b70
http://europepmc.org/articles/PMC7007523
http://europepmc.org/articles/PMC7007523
Autor:
Jan Homolak, Jelena Osmanovic Barilar, Melita Salkovic-Petrisic, Ana Babic Perhoc, Ana Knezovic
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 548
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 548, p 548 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 548, p 548 (2022)
SummaryThe incretin system is an emerging new field that might provide valuable contributions to the research of both pathophysiology and therapeutic strategies in the treatment of diabetes, obesity, and neurodegenerative disorders. This study aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc3b745c1856fd0a853c582c768edd9
Autor:
Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Josè Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi, Umberto Dianzani, Davide Corà
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Immunology, 13:915963. Frontiers Media SA
instname
Frontiers in Immunology, 13:915963. Frontiers Media SA
14 p.-5 fig. This work is dedicated to the memory of our colleague SZ. SZ was an extraordinary person, a great friend, a remarkable scholar and an unfailing mentor for our students. Her passion for life and research will always be an example. We miss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbe1e33905219153c9d1f4c24800e8e
http://hdl.handle.net/10261/280405
http://hdl.handle.net/10261/280405
Autor:
Marta Gil-Ortega, Beatriz Somoza, María S. Fernández-Alfonso, Marta Viana, M. Paz Lorenzo, Martín Alcalá, Thomas Unger, Raquel González-Blázquez, William A. Boisvert, Ulrike Muscha Steckelings
Publikováno v:
González-Blázquez, R, Alcalá, M, Fernández-Alfonso, M S, Steckelings, U M, Lorenzo, M P, Viana, M, Boisvert, W, Unger, T, Ortega, M G & Somoza, B 2021, ' C21 preserves endothelial function in the thoracic aorta from DIO mice : role for AT2, Mas and B2 receptors ', Clinical Science, vol. 135, no. 9, pp. 1145-1163 . https://doi.org/10.1042/CS20210049
Clinical Science, 135(9), 1145-1163. Portland Press Ltd.
Clinical Science, 135(9), 1145-1163. Portland Press Ltd.
Compound 21 (C21), a selective agonist of angiotensin II type 2 receptor (AT2R), induces vasodilation through NO release. Since AT2R seems to be overexpressed in obesity, we hypothesize that C21 prevents the development of obesity-related vascular al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877a98634f9c9ee846c5eeeae1f14062
https://portal.findresearcher.sdu.dk/da/publications/d3fcf2be-7770-4967-9d40-5384bb58c9fe
https://portal.findresearcher.sdu.dk/da/publications/d3fcf2be-7770-4967-9d40-5384bb58c9fe
Publikováno v:
Cells
Cells, Vol 10, Iss 1095, p 1095 (2021)
Cells, Vol 10, Iss 1095, p 1095 (2021)
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaf70488006988fb844a4a694beb3de
https://doi.org/10.3390/cells10051095
https://doi.org/10.3390/cells10051095
Autor:
Isabelle Vanhoutte, Eugenia Russinova, Lucas Alves Neubus Claus, Rajesh Kumar, Peng Wang, Wei Siao, Daniël Van Damme, Jiří Friml, Derui Liu, Xiuyang Zhao, Grégory Vert, Alexander W. Johnson, Klaas Yperman, Sara Martins, Kyle W. Bender
Publikováno v:
The Plant cell
The Plant cell, 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant cell, American Society of Plant Biologists (ASPB), 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant Cell
Plant Cell
PLANT CELL
The Plant cell, 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant cell, American Society of Plant Biologists (ASPB), 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant Cell
Plant Cell
PLANT CELL
Clathrin-mediated endocytosis (CME) and its core endocytic machinery are evolutionarily conserved across all eukaryotes. In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) sorts plasma membrane (PM) cargoes into vesicles via the recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec08c8065097cd661ef9eb3cf1e34d47
https://ut3-toulouseinp.hal.science/hal-03361355
https://ut3-toulouseinp.hal.science/hal-03361355