Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Protein Kinases/genetics"'
Autor:
Lenises de Paula van der Steld, Mario de Seixas Rocha, Ana Marice Teixeira Ladeia, Humberto Lago Livramento, Gervásio Batista Campos, Francisco Carlos da Costa Darrieux, Oscar Campuzano, Ramon Brugada
Publikováno v:
Einstein (São Paulo), Vol 22 (2024)
ABSTRACT Objective This study aimed to provide a long-term follow-up of PRKAG2 syndrome and describe the new phenotypic aspects of the condition. PRKAG2 syndrome is a rare autosomal-dominant glycogen storage disease characterized by cardiac hypertrop
Externí odkaz:
https://doaj.org/article/b477a0c0b169440da04a9db30e553c04
Autor:
Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider
Publikováno v:
The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022)
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aac092c3c348fbc7d9f09e908c72f48
https://doi.org/10.1042/bcj20220170
https://doi.org/10.1042/bcj20220170
Autor:
Satoshi Fujita, Andrea Moretti, Niko Geldner, Alexandre Pfister, Michael Hothorn, Ulrich Hohmann, Benjamin Brandt, Yan Ma, Satohiro Okuda, Verónica G. Doblas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (5), pp.2693-2703. ⟨10.1073/pnas.1911553117⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 5, pp. 2693-2703
Proceedings of the National Academy of Sciences, Vol. 117, No 5 (2020) pp. 2693-2703
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (5), pp.2693-2703. ⟨10.1073/pnas.1911553117⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 5, pp. 2693-2703
Proceedings of the National Academy of Sciences, Vol. 117, No 5 (2020) pp. 2693-2703
Significance Plants have evolved unique membrane receptor kinases with extracellular leucine-rich repeat domains that regulate diverse developmental processes and that form the first layer of the plant immune system. Here it is shown that 2 sequence-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38e2e004a09d73780577563c8337b70
http://europepmc.org/articles/PMC7007523
http://europepmc.org/articles/PMC7007523
Autor:
Robert E. Lewis, Robert A. Svoboda, Kurt W. Fisher, Chaitra Rao, Hans Clevers, Chittibabu Guda, Adrian R. Black, Siddesh Southekal, Tomohiro Mizutani, Danielle E. Frodyma, Keith R. Johnson
Publikováno v:
eLife, 10. eLife Sciences Publications
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here, we show that KSR1 and ERK promote EMT-like phenotype through the preferential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bb2042ad67232ddc7d12f35e2d41bc
https://pure.knaw.nl/portal/en/publications/a93f93c2-06c8-4529-b2df-02797c4ce103
https://pure.knaw.nl/portal/en/publications/a93f93c2-06c8-4529-b2df-02797c4ce103
Autor:
David Carling, Dorian O. Haskard, Søren K. Moestrup, Justin C. Mason, L. Cave, Joseph J. Boyle, A. Seneviratne, Gareth Hyde
Publikováno v:
Seneviratne, A, Cave, L, Hyde, G, Moestrup, S K, Carling, D, Mason, J C, Haskard, D O & Boyle, J J 2021, ' Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase ', Cardiovascular Research, vol. 117, no. 5, pp. 1295-1308 . https://doi.org/10.1093/cvr/cvaa171
Cardiovascular Research
Cardiovascular Research
Aims Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque hemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and ATF1. The anti-diabetic drug metformin may also activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da685d70a2d1fb7b288da50784ff2a
https://pure.au.dk/portal/da/publications/metformin-directly-suppresses-atherosclerosis-in-normoglycaemic-mice-via-haematopoietic-adenosine-monophosphateactivated-protein-kinase(85ce7ecf-04fc-41c3-957e-86935662d77a).html
https://pure.au.dk/portal/da/publications/metformin-directly-suppresses-atherosclerosis-in-normoglycaemic-mice-via-haematopoietic-adenosine-monophosphateactivated-protein-kinase(85ce7ecf-04fc-41c3-957e-86935662d77a).html
Autor:
Isabelle Vanhoutte, Eugenia Russinova, Lucas Alves Neubus Claus, Rajesh Kumar, Peng Wang, Wei Siao, Daniël Van Damme, Jiří Friml, Derui Liu, Xiuyang Zhao, Grégory Vert, Alexander W. Johnson, Klaas Yperman, Sara Martins, Kyle W. Bender
Publikováno v:
The Plant cell
The Plant cell, 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant cell, American Society of Plant Biologists (ASPB), 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant Cell
Plant Cell
PLANT CELL
The Plant cell, 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant cell, American Society of Plant Biologists (ASPB), 2020, 32 (11), pp.3598-3612. ⟨10.1105/tpc.20.00384⟩
The Plant Cell
Plant Cell
PLANT CELL
Clathrin-mediated endocytosis (CME) and its core endocytic machinery are evolutionarily conserved across all eukaryotes. In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) sorts plasma membrane (PM) cargoes into vesicles via the recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec08c8065097cd661ef9eb3cf1e34d47
https://ut3-toulouseinp.hal.science/hal-03361355
https://ut3-toulouseinp.hal.science/hal-03361355
Autor:
Jing Ma, Peixin Yang, Bin Gao, Robim Marcelino Rodrigues, Seonghwan Hwang, Haixia Cao, Dechun Feng, Ruixue Ren, Suthat Liangpunsakul, Yong He, Jian Sun, Mingjiang Xu, Tianyi Ren
Publikováno v:
JCI Insight
Alcohol-associated liver disease is a spectrum of liver disorders with histopathological changes ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Recent data suggest that chronic-plus-binge ethanol intake ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adeef2c85a140e54ad04509355c9188
https://doi.org/10.1172/jci.insight.136496
https://doi.org/10.1172/jci.insight.136496
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
This article is a result of the project Norte-01-0145-FEDER-000008 -Porto Neurosciences and Neurologic Disease Research Initiative at I3Ssupported by Norte Portugal Regional Operational Programme (NORTE2020), under the PORTUGAL 2020 Partnership Agree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885d225738f4eabee224c24127955846
https://hdl.handle.net/10216/130573
https://hdl.handle.net/10216/130573
Publikováno v:
American Journal of Human Genetics. 102(6):1195-1203
Next-generation sequencing is a powerful tool for the discovery of genes related to neurodevelopmental disorders (NDDs). Here, we report the identification of a distinct syndrome due to de novo or inherited heterozygous mutations in Tousled-like kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::858662ced98253165fe7b753f5156b3b
https://doi.org/10.1016/j.ajhg.2018.04.014
https://doi.org/10.1016/j.ajhg.2018.04.014
Autor:
Zlatko Marušić, Sofia Y. Chen, Alena Pance, Nicolas De Saint Aubain, Boštjan Luzar, Marie S Abi Daoud, Arno Rütten, Francesca Butera, Sandra Louzada, Thomas Mentzel, Louise van der Weyden, Carla Daniela Robles-Espinoza, Paul W. Harms, Michiel P J van der Horst, Steven D. Billings, Jason L. Hornick, Chris Bakal, Thomas Brenn, Ingrid Ferreira, Jennifer S. Ko, James Hewinson, David J. Adams, Guia Cerretelli, Rajiv M. Patel, Mark J. Arends, Mamunur Rashid
Publikováno v:
Nature communications, 10 (1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Rashid, M, van der Horst, M, Mentzel, T, Butera, F, Ferreira, I, Pance, A, Rütten, A, Luzar, B, Marusic, Z, de Saint Aubain, N, Ko, J S, Billings, S D, Chen, S, Abi-Daoud, M, Hewinson, J, Louzada, S, Harms, P W, Cerretelli, G, Robles-Espinoza, C D, Patel, R M, van der Weyden, L, Bakal, C, Hornick, J L, Arends, M J, Brenn, T & Adams, D J 2019, ' ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma ', Nature Communications, vol. 10, 2213 . https://doi.org/10.1038/s41467-019-09979-0
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Rashid, M, van der Horst, M, Mentzel, T, Butera, F, Ferreira, I, Pance, A, Rütten, A, Luzar, B, Marusic, Z, de Saint Aubain, N, Ko, J S, Billings, S D, Chen, S, Abi-Daoud, M, Hewinson, J, Louzada, S, Harms, P W, Cerretelli, G, Robles-Espinoza, C D, Patel, R M, van der Weyden, L, Bakal, C, Hornick, J L, Arends, M J, Brenn, T & Adams, D J 2019, ' ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma ', Nature Communications, vol. 10, 2213 . https://doi.org/10.1038/s41467-019-09979-0
Nature Communications
Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 representative patients includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7805e8b278a80914f13e1620a57749e
https://doi.org/10.1038/s41467-019-09979-0
https://doi.org/10.1038/s41467-019-09979-0