Zobrazeno 1 - 10
of 3 311
pro vyhledávání: '"Protein Kinase Inhibitor"'
Autor:
Robert Roskoski Jr.
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107465- (2024)
Lung cancer is the leading cause of cancer deaths in the United States and the world. It is divided into two major types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In the tumor-node-metastasis (TNM) cancer-staging classifi
Externí odkaz:
https://doaj.org/article/1098f4c94b314deb9702a8bdf2335bd8
Publikováno v:
TNOA Journal of Ophthalmic Science and Research, Vol 62, Iss 3, Pp 368-370 (2024)
Fibroblast growth factor receptor (FGFR) plays a major role in maintaining retinal pigment epithelium cells. Drugs that inhibit the FGFR pathway block the activation of the mitogen-activated protein kinase pathway, leading to the synthesis of antiapo
Externí odkaz:
https://doaj.org/article/c43d1ca8762f42eebb1584eab55bb370
Autor:
Qing LIU, Haitian LI, Bin LI, Meiyu REN, Zhenqing LI, Yuzhen CHEN, Zhizhong ZHENG, Yuqi MENG, Haiming FENG
Publikováno v:
Chinese Journal of Lung Cancer, Vol 26, Iss 7, Pp 523-537 (2023)
Background and objective Lung cancer is the leading cause of cancer-related death worldwide, and patients have limited survival benefits from traditional treatments such as surgery, radiotherapy and chemotherapy. As a new treatment for lung cancer, i
Externí odkaz:
https://doaj.org/article/926a39cf81f24f0c9e2b8ce81d3fab67
Autor:
Tatsuya Hayashi, Shinji Otani, Riko Kitazawa, Takashi Ueki, Takao Ishimura, Takahito Sugihara, Fumiya Ogura, Yousuke Kiriyama, Yu Mori, Nobuhiko Sakao, Yoshifumi Sano, Hironori Izutani
Publikováno v:
Respiratory Medicine Case Reports, Vol 48, Iss , Pp 101956- (2024)
Lung sarcomatoid carcinoma is a rare tumor. We report a rare case of pancreatic metastasis in a 76-year-old man with lung sarcomatoid carcinoma. Right upper lobectomy was performed, and the patient was diagnosed with pulmonary sarcomatoid carcinoma w
Externí odkaz:
https://doaj.org/article/195c89e82d154d70ac21f99c76580945
Autor:
Constance Bordet, Mahmoud Zureik, Yoann Zelmat, Margaux Lafaurie, Maryse Lapeyre-Mestre, Agnès Sommet, Julien Mazieres, Fabien Despas
Publikováno v:
Cancer Treatment and Research Communications, Vol 39, Iss , Pp 100801- (2024)
Introduction: Previous studies have identified an interaction between protein kinase inhibitors (PKIs) and proton pump inhibitors (PPIs) in patients with lung cancer. This type of interaction may reduce the efficacy of PKIs. However, the effect of PK
Externí odkaz:
https://doaj.org/article/012686143a2f4bea870c06999765110f
Publikováno v:
Saudi Pharmaceutical Journal, Vol 31, Iss 6, Pp 989-997 (2023)
In the last twenty years, protein kinases have been identified as important targets for cancer therapy. In order to prevent unexpected toxicity, medicinal chemists have always focused on discovering selective protein kinase inhibitors. However, cance
Externí odkaz:
https://doaj.org/article/f448e854bb2b4d7885af89d3af72a380
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 11, Pp n/a-n/a (2023)
Successful engineering of functional salivary glands necessitates the creation of cell‐instructive environments for ex vivo expansion and lineage specification of primary human salivary gland stem cells (hS/PCs). Herein, basement membrane mimetic h
Externí odkaz:
https://doaj.org/article/81218c25b925433a8374c8b2c07aadc3
Autor:
Nan Bi, Kunpeng Xu, Hong Ge, Ming Chen, Mingyan E, Li Zhang, Jianzhong Cao, Xu Zhang, Xiao Ding, Bing Xia, Lujun Zhao, Lijie Han, Jiancheng Li, Chen Hu, Luhua Wang
Publikováno v:
Journal of the National Cancer Center, Vol 3, Iss 1, Pp 65-71 (2023)
Objective: To investigate the optimal management of patients with epidermal growth factor receptor gene (EGFR) mutant locally advanced non-small cell lung cancer (LA-NSCLC). Methods: Patients with unresectable stage III lung adenocarcinoma (LAC) harb
Externí odkaz:
https://doaj.org/article/47737508e36640cf83c7594c1ba22ddf
Autor:
Yu Mizuno, Naoki Okada, Hiromitsu Onoe, Kana Tokumo, Hideaki Okumichi, Kazuyuki Hirooka, Yoshiaki Kiuchi
Publikováno v:
BMC Ophthalmology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background Rho-kinase inhibitors can inhibit fibrosis after glaucoma surgery. This study aimed to evaluate the effect of rho-kinase inhibitor after needling procedure with mitomycin C for the failure of filtering bleb with trabeculectomy. Me
Externí odkaz:
https://doaj.org/article/2402732827be4ec88a03ea527e0a6cf9
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast cancer. In this stud
Externí odkaz:
https://doaj.org/article/526323faf7ee43288639c97874d1193c