Zobrazeno 1 - 10
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pro vyhledávání: '"Protein Evolution"'
Autor:
Claire D McWhite, Wisath Sae-Lee, Yaning Yuan, Anna L Mallam, Nicolas A Gort-Freitas, Silvia Ramundo, Masayuki Onishi, Edward M Marcotte
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 933-951 (2024)
Abstract The variability of proteins at the sequence level creates an enormous potential for proteome complexity. Exploring the depths and limits of this complexity is an ongoing goal in biology. Here, we systematically survey human and plant high-th
Externí odkaz:
https://doaj.org/article/6953cb1a1b2148c5b640f8b922f7ea45
Akademický článek
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Autor:
Laura M Chamness, Charles P Kuntz, Andrew G McKee, Wesley D Penn, Christopher M Hemmerich, Douglas B Rusch, Hope Woods, Dyotima, Jens Meiler, Jonathan P Schlebach
Publikováno v:
eLife, Vol 12 (2024)
Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evo
Externí odkaz:
https://doaj.org/article/87e6dc4267994ade8aebd09e14ada9b5
Autor:
Ai Nguyen, Huaying Zhao, Dulguun Myagmarsuren, Sanjana Srinivasan, Di Wu, Jiji Chen, Grzegorz Piszczek, Peter Schuck
Publikováno v:
eLife, Vol 13 (2024)
Genetic diversity is a hallmark of RNA viruses and the basis for their evolutionary success. Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the impact of mutations across the spectrum of viable amino acid sequences
Externí odkaz:
https://doaj.org/article/69a87aec0aa54120ac8389e03fc2cdf5
Autor:
Thomas Kuhlman
Publikováno v:
eLife, Vol 13 (2024)
A new study reveals how naturally occurring mutations affect the biophysical properties of nucleocapsid proteins in SARS-CoV-2.
Externí odkaz:
https://doaj.org/article/cf34a73b55034aa892935994176e10e4
Publikováno v:
Advanced Science, Vol 11, Iss 22, Pp n/a-n/a (2024)
Abstract Base editors (BEs) are widely used as revolutionary genome manipulation tools for cell evolution. To screen the targeted individuals, it is often necessary to expand the editing window to ensure highly diverse variant library. However, curre
Externí odkaz:
https://doaj.org/article/f3cd7d1c09ff446f97201f57a7fd3aae
Autor:
Simon Schröder, Anja Richter, Talitha Veith, Jackson Emanuel, Luca Gudermann, Kirstin Friedmann, Lara M. Jeworowski, Barbara Mühlemann, Terry C. Jones, Marcel A. Müller, Victor M. Corman, Christian Drosten
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly map
Externí odkaz:
https://doaj.org/article/faa93fcd2deb4a35b9efcfc3602c8045
Autor:
Samuel King, Xinyi E. Chen, Sarah W. S. Ng, Kimia Rostin, Samuel V. Hahn, Tylo Roberts, Janella C. Schwab, Parneet Sekhon, Madina Kagieva, Taylor Reilly, Ruo Chen Qi, Paarsa Salman, Ryan J. Hong, Eric J. Ma, Steven J. Hallam
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
The emergence of SARS-CoV-2 variants during the COVID-19 pandemic caused frequent global outbreaks that confounded public health efforts across many jurisdictions, highlighting the need for better understanding and prediction of viral evolution. Pred
Externí odkaz:
https://doaj.org/article/011ef3ffa8dc455f8f0b6b1cdd7029fe
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100142- (2024)
Binding of nucleotides and their derivatives is one of the most ancient elementary functions dating back to the Origin of Life. We review here the works considering one of the key elements in binding of (di)nucleotide-containing ligands – phosphate
Externí odkaz:
https://doaj.org/article/6d225fb39eab47c59ab5526adbc3bd5d
Autor:
Aurora Alvarez-Buylla, Marie-Therese Fischer, Maria Dolores Moya Garzon, Alexandra E Rangel, Elicio E Tapia, Julia T Tanzo, H Tom Soh, Luis A Coloma, Jonathan Z Long, Lauren A O'Connell
Publikováno v:
eLife, Vol 12 (2023)
Alkaloids are important bioactive molecules throughout the natural world, and in many animals they serve as a source of chemical defense against predation. Dendrobatid poison frogs bioaccumulate alkaloids from their diet to make themselves toxic or u
Externí odkaz:
https://doaj.org/article/b1c6b485f2314d7691dcb9e6dd22c743