Zobrazeno 1 - 10
of 696
pro vyhledávání: '"Protein Dimerization"'
Publikováno v:
Current Research in Structural Biology, Vol 8, Iss , Pp 100158- (2024)
Mutations in the IQSEC2 gene result in severe intellectual disability, epilepsy and autism. The primary function of IQSEC2 is to serve as a guanine exchange factor (GEF) controlling the activation of ARF6 which in turn mediates membrane trafficking a
Externí odkaz:
https://doaj.org/article/65ec50d393f348a8a9b739160e39b106
Autor:
Stilling, Simon, Kalliakoudas, Theodoros, Benninghoven-Frey, Hannah, Inoue, Takanari, Falkenburger, Björn H
Primary cilia are sensory organelles on many postmitotic cells. The ciliary membrane is continuous with the plasma membrane but differs in its phospholipid composition with phosphatidylinositol 4,5-bisposphate (PIP₂) being much reduced toward the c
Externí odkaz:
https://tud.qucosa.de/id/qucosa%3A90438
https://tud.qucosa.de/api/qucosa%3A90438/attachment/ATT-0/
https://tud.qucosa.de/api/qucosa%3A90438/attachment/ATT-0/
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2687-2698 (2020)
Protein kinases are crucial components of the cell-signalling machinery that orchestrate and convey messages to their downstream targets. Most often, kinases are activated upon a phosphorylation to their activation loop, which will shift the kinase i
Externí odkaz:
https://doaj.org/article/d1509c32ab514978a93762aa5f195179
Autor:
Camille Albrecht, Andrey S. Kuznetsov, Aline Appert-Collin, Zineb Dhaideh, Maïté Callewaert, Yaroslav V. Bershatsky, Anatoly S. Urban, Eduard V. Bocharov, Dominique Bagnard, Stéphanie Baud, Sébastien Blaise, Béatrice Romier-Crouzet, Roman G. Efremov, Manuel Dauchez, Laurent Duca, Marc Gueroult, Pascal Maurice, Amar Bennasroune
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Sialidases, or neuraminidases, are involved in several human disorders such as neurodegenerative, infectious and cardiovascular diseases, and cancers. Accumulative data have shown that inhibition of neuraminidases, such as NEU1 sialidase, may be a pr
Externí odkaz:
https://doaj.org/article/07a99ce083d34a60866086896cbe236a
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of regulatory T cells. CD28 is expressed at the cell surface as a disulfide linked
Externí odkaz:
https://doaj.org/article/89425e7d417b4e5f885057b1d3f8ba78
Autor:
Yong Feng, Ping Wu, Weiwei Fu, Liwei Peng, Hui Zhu, Yangrong Cao, Xinan Zhou, Zonglie Hong, Zhongming Zhang, Songli Yuan
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
The symbiosis receptor kinase SymRK plays an essential role in symbiotic signal transduction and nodule organogenesis. Several proteins bind to SymRK, but how the symbiosis signals are transduced from SymRK to downstream components remains elusive. W
Externí odkaz:
https://doaj.org/article/d13535fe749a406e8b5ea94f9f172f44
Autor:
Camille Albrecht, Aline Appert-Collin, Dominique Bagnard, Sébastien Blaise, Béatrice Romier-Crouzet, Roman G. Efremov, Hervé Sartelet, Laurent Duca, Pascal Maurice, Amar Bennasroune
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Cellular functions are regulated by extracellular signals such as hormones, neurotransmitters, matrix ligands, and other chemical or physical stimuli. Ligand binding on its transmembrane receptor induced cell signaling and the recruitment of several
Externí odkaz:
https://doaj.org/article/30391ff90a5d4e85a5ed117b0ed6e268
Autor:
David Atac, Lucas Mohn, Silke Feil, Kevin Maggi, Dominik Haenni, Britta Seebauer, Samuel Koller, Wolfgang Berger
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1053 (2022)
Basic helix–loop–helix (bHLH) transcription factors are evolutionarily conserved and structurally similar proteins important in development. The temporospatial expression of atonal bHLH transcription factor 7 (ATOH7) directs the differentiation o
Externí odkaz:
https://doaj.org/article/69a4175b9d494a97992f9d85c8daf3f9
Autor:
Ewa Joachimiak, Ewa Waclawek, Michal Niziolek, Anna Osinka, Hanna Fabczak, Jacek Gaertig, Dorota Wloga
Publikováno v:
Cells, Vol 9, Iss 2, p 292 (2020)
Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker. The AAA domain o
Externí odkaz:
https://doaj.org/article/85909d1c2ff74d5290d930221a37c2a8