Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of particle size and surface functionalization

Autor: Amrita Banerjee, Lloyd O. Billey, Weilin L. Shelver

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 12 (2021)
PLoS ONE, Vol 16, Iss 12, p e0260803 (2021)

Toxicity of micro or nanoplastics (MP/NP) in aquatic life is well-documented, however, information about the consequences of exposure to these particles in terrestrial species is scarce. This study was used to evaluate the uptake and/or toxicity of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089a7c07d4332c5ef15e0da27e957561
http://europepmc.org/articles/PMC8719689

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling

Autor: Darwesh Mohideen Kaderbatcha Aladin, Yeh Shiu Chu, Shuo Shen, Robert Charles Robinson, Sylvie Dufour, Virgile Viasnoff, Nicolas Borghi, Jean Paul Thiery

Publikováno v: PLoS ONE
PLoS ONE, 2021, 16 (12), pp.e0260593. ⟨10.1371/journal.pone.0260593⟩
PLoS ONE, Public Library of Science, 2021, 16 (12), pp.e0260593. ⟨10.1371/journal.pone.0260593⟩
PLoS ONE, Vol 16, Iss 12, p e0260593 (2021)

International audience; Cadherins control intercellular adhesion in most metazoans. In vertebrates, intercellular adhesion differs considerably between cadherins of type-I and type-II, predominantly due to their different extracellular regions. Yet,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8c60d77733b064573d718bb30a4ff4
https://doi.org/10.1371/journal.pone.0260593

Marked variability in bioactivity between commercially available bovine colostrum for human use; implications for clinical trials

Autor: Meg Cattell, Raymond J. Playford, Tania Marchbank

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0234719 (2020)

BackgroundColostrum, the milk produced during first few days after birth, is rich in immunoglobulins, antimicrobial peptides & growth factors. Multiple clinical trials using bovine colostrum are ongoing but with no assessment of test product bioactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf849c6daba3eda20a3caaf8fdc8064
https://pubmed.ncbi.nlm.nih.gov/33022011

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors

Autor: Elsa D. Garcin, Laurence Lamy, Joshua D. Amason, James Inglese, Ryan MacArthur, Jeffrey S. Rubin, Teresa L. Burgess, Catherine L. Farrell, Thomas W. Miller, Patricia Dranchak, John C. Braisted, David D. Roberts

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)

CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9f71df68c89b0c1dc0cddf807f4f74
http://europepmc.org/articles/PMC6611588

Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2

Autor: Sawsan Ibrahim Kreydiyyeh, Layla El Moussawi, Mohamed Chakkour

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0193139 (2018)
PLoS ONE

Epinephrine, a key stress hormone, is known to affect ion transport in the colon. Stress has been associated with alterations in colonic functions leading to changes in water movements manifested as diarrhea or constipation. Colonic water movement is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f12193e348fc5019b3d87e101944db3
http://europepmc.org/articles/PMC5821373?pdf=render