Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Protein Cereblon"'
Autor:
Kuniko Katagiri, Miku Ishizawa, Mari Kannagi, Yoshiko Nagano, Nobuyo Kondo, Atsuhiko Hasegawa, Takeru Yoneda, Takao Masuda
Publikováno v:
Biochemical and Biophysical Research Communications. 574:104-109
Immunomodulatory imide drugs (IMiDs), such as lenalidomide and pomalidomide, exert pleiotropic effects, e.g., antitumor effects in multiple myeloma, by binding the protein Cereblon and altering its substrate specificity. Lenalidomide is approved for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe06cf106d4b970ac3f36f9083b9dc1
https://doi.org/10.1016/j.bbrc.2021.08.051
https://doi.org/10.1016/j.bbrc.2021.08.051
Autor:
Heung Kyoung Lee, Ara Go, Jong Yeon Hwang, Sung Goo Park, Young Uk Jeon, Jae Du Ha, Sung Yun Cho, Chi Hoon Park, Pilho Kim, Sun Jun Park, Ji-Eun Kim, Jeong Hoon Kim, Seung-Hyun Jo, Byoung Chul Park, Chong-Ock Lee, Sung Ah Kim, Sunhong Kim
Publikováno v:
European Journal of Medicinal Chemistry. 166:65-74
Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon (CRBN) and subsequently degrading IKZF1/3. Recently, their ability to recruit E3 ubiquitin ligase has been used in the proteolysis targeting chimera (PROTAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1926b61f0b5589af19191e24dea31c1f
https://doi.org/10.1016/j.ejmech.2019.01.023
https://doi.org/10.1016/j.ejmech.2019.01.023
Autor:
Cinzia Fionda, Marco Cippitelli, Silvia Ruggeri, Andrea Kosta, Angela Gismondi, Giovanna Peruzzi, Cristina Capuano, Helena Stabile, Alessandra Zingoni, Angela Santoni, Rossella Paolini, Alessandra Soriani, Rosa Molfetta
Rearrangement of the actin cytoskeleton is critical for cytotoxic and immunoregulatory functions as well as migration of Natural Killer (NK) cells. However, dynamic reorganization of actin is a complex process which remains largely unknown. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f838d274c9e66c837ca983835d81529b
http://hdl.handle.net/11573/1569443
http://hdl.handle.net/11573/1569443
Autor:
Neil Vargesson, Nigel H. Greig, Marc C. Nicklaus, Matthew K Collins, Christian Steinebach, Weiming Luo, Michael Gütschow, Suzana Markolovic, David Tweedie, Shaunna L. Beedie, Cindy H. Chau, William D. Figg, Megan L. Peach
Publikováno v:
Molecules
Volume 25
Issue 23
Molecules, Vol 25, Iss 5683, p 5683 (2020)
Volume 25
Issue 23
Molecules, Vol 25, Iss 5683, p 5683 (2020)
Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731478efd668710d777dd2be1b22f948
Autor:
Reinhard Albrecht, Kerstin Bär, Hartmann, Christopher Heim, B. Hernandez Alvarez, Andrei N. Lupas, I. Boichenko, Silvia Deiss
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 11163-11171 (2018)
ACS Omega
ACS Omega
The protein cereblon serves as a substrate receptor of a ubiquitin ligase complex that can be tuned toward different target proteins by cereblon-binding agents. This approach to targeted protein degradation is exploited in different clinical settings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834de1494e493f87cf0e58d864180f25
https://doaj.org/article/7bf83f3391aa4e889b6bc9f635e3012a
https://doaj.org/article/7bf83f3391aa4e889b6bc9f635e3012a
Autor:
Yoshitaka Satoh, Gilles Carmel, Frans Baculi, Peter H. Schafer, Laurie LeBrun, Matt Hickman, Thomas O. Daniel, Brian E. Cathers, James Carmichael, Godrej Khambatta, Hon-Wah Man, Mary E Matyskiela, Philip P Chamberlain, Weihong Zhang, Mariko Riley, George W. Muller, Barbra Pagarigan, Gang Lu, Chin-Chun Lu
Publikováno v:
Journal of Medicinal Chemistry. 61:535-542
The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to cause their ubiquitination and degradation. Here we describe CC-220 (compound 6), a cereblon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3ec7b8486c677242241f929022984b
https://doi.org/10.1021/acs.jmedchem.6b01921
https://doi.org/10.1021/acs.jmedchem.6b01921
Autor:
Philip P Chamberlain, Brian E. Cathers
Publikováno v:
Drug discovery today. Technologies. 31
Targeted protein degradation has become an exciting new paradigm in drug discovery with the potential to target new protein families for therapeutic intervention. In 2010, Hiroshi Handa and colleagues discovered that the drug thalidomide binds to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812b5b4d11fdfb3011a7c903df3cd473
https://pubmed.ncbi.nlm.nih.gov/31200856
https://pubmed.ncbi.nlm.nih.gov/31200856
Autor:
O. Fuchs, R. Bokorova
Publikováno v:
Drugs of the Future. 45:305
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::403a6d6d027fa461cdbee704dda13c8d
https://doi.org/10.1358/dof.2020.45.5.3116300
https://doi.org/10.1358/dof.2020.45.5.3116300
Autor:
Tadao Ishida, Yu Abe
Publikováno v:
Japanese journal of clinical oncology. 49(8)
The prognosis of multiple myeloma was quite poor in the last century, but it has significantly improved with the incorporation of novel agents, immunomodulatory drugs (IMiDs) and proteasome inhibitors. Thalidomide was first developed as a sedative in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabaa62dc81c963a65a951f24cc3cade
https://pubmed.ncbi.nlm.nih.gov/31187860
https://pubmed.ncbi.nlm.nih.gov/31187860
Autor:
Andrei N. Lupas, Murray Coles, Marcus D. Hartmann, Fabio Zanini, Birte Hernandez Alvarez, I. Boichenko
Publikováno v:
Journal of Structural Biology. 188:225-232
Thalidomide and its derivatives lenalidomide and pomalidomide are important anticancer agents but can cause severe birth defects via an interaction with the protein cereblon. The ligand-binding domain of cereblon is found, with a high degree of conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ca4bf621b6a107d4cf9aade122105e
https://doi.org/10.1016/j.jsb.2014.10.010
https://doi.org/10.1016/j.jsb.2014.10.010