Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Protein Arginine N-Methyltransferase 5"'
Autor:
Wafaa Abumustafa, Darko Castven, Fatemeh Saheb Sharif-Askari, Batoul Abi Zamer, Mawieh Hamad, Jens-Uwe Marquardt, Jibran Sualeh Muhammad
Publikováno v:
Biology, Vol 13, Iss 4, p 216 (2024)
Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating the hepatocellular carcinoma (HCC) transcriptome remains poorly understood. In this study,
Externí odkaz:
https://doaj.org/article/7ed6f199d3964bc5b98456735e80f93e
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Troy L, Lowe, Steven G, Clarke
Publikováno v:
The Journal of biological chemistry, vol 298, iss 9
Protein arginine methylation is involved in many biological processes and can be enhanced in cancer. In mammals, these reactions are catalyzed on multiple substrates by a family of nine protein arginine methyltransferases (PRMTs). However, conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20c9c1277045c966b9bf30e3d4e02bf
https://escholarship.org/uc/item/3pm9c1p7
https://escholarship.org/uc/item/3pm9c1p7
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jibran Sualeh Muhammad, Mawieh Hamad, Wafaa Abumustafa, Batoul Abi Zamer, Bariaa A. Khalil, Azzam A. Maghazachi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss, Pp 112368-(2022)
Protein arginine N-methyltransferase 5 (PRMT5) enzyme is one of the eight canonical PRMTs, classified as a type II PRMT, induces arginine monomethylation and symmetric dimethylation. PRMT5 is known to be overexpressed in multiple cancer types, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0078cca74be710fbe3af4bd6e1649a77
https://pubmed.ncbi.nlm.nih.gov/34794114
https://pubmed.ncbi.nlm.nih.gov/34794114
Autor:
Weiwei Liu, Cen Xie, Yuqing Gao, Ying Wang, Wei Tang, Xiaozhen Guo, Shogo Takahashi, Lei Chen, Lulu Sun, Kristopher W. Krausz, Aijuan Qu, Yuan Yang, Jie Jiang, Shoumei Yang, Jie Cai, Frank J. Gonzalez, Yuhong Luo
Publikováno v:
Hepatology
BACKGROUND AND AIMS: HCC is a leading cause of cancer-related deaths globally with poor outcome and limited therapeutic options. Although the myelocytomatosis (MYC) oncogene is frequently dysregulated in HCC, it is thought to be undruggable. Thus, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca2b5900c99ddc7bd2dd9e87aeb2c2c
https://europepmc.org/articles/PMC9942701/
https://europepmc.org/articles/PMC9942701/
Autor:
Nobuya Sakai, Yorihisa Imanishi, Taka-aki Koshimizu, Takashi Shiraki, Yoko Fujiwara, Katsushi Shibata, Yumiko Saito
Publikováno v:
Biochemical and Biophysical Research Communications. 467:778-784
The candidate tumor suppressor gene RASSF1A (Ras-association domain family 1, isoform A) is inactivated in many types of adult and childhood cancers. However, the mechanisms by which RASSF1A exerts tumor suppressive functions have yet to be elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421409d203fed5d56bc1c5bcaa11bc4c
https://doi.org/10.1016/j.bbrc.2015.10.065
https://doi.org/10.1016/j.bbrc.2015.10.065
Publikováno v:
The Journal of biological chemistry, vol 290, iss 27
Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splicing of pre-mRNA. Site-directed mutagenesis studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb9fe47c55c7775d9196969edda48c2
https://doi.org/10.1074/jbc.m115.659433
https://doi.org/10.1074/jbc.m115.659433
Autor:
Richard E. Lloyd, Gianluca Sbardella, Lucas C. Reineke, Sitaram Gayatri, Wei-Chih Tsai, Mark T. Bedford
Publikováno v:
The Journal of biological chemistry. 291(43)
Stress granules (SGs) are cytoplasmic condensates of stalled messenger ribonucleoprotein complexes (mRNPs) that form when eukaryotic cells encounter environmental stress. RNA-binding proteins are enriched for arginine methylation and facilitate SG as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0131b822dbaa5c0d9c60538519f4e9
https://pubmed.ncbi.nlm.nih.gov/27601476
https://pubmed.ncbi.nlm.nih.gov/27601476
Autor:
Madhulata Kumari, Subhash Chandra
Publikováno v:
International Journal of Computational Biology and Drug Design. 10:79
Curcumin has anticancer properties but the mechanism of anticancer action is not well understood. By molecular docking simulation, we show that curcumin could interact specifically with protein arg...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bf1e1997d0bf30ee5597cbfdf7b7c0
https://doi.org/10.1504/ijcbdd.2017.082818
https://doi.org/10.1504/ijcbdd.2017.082818