Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Proteasome regulatory particle"'
Publikováno v:
Bioengineered, Vol 12, Iss 1, Pp 7459-7469 (2021)
Bioengineered
article-version (VoR) Version of Record
Bioengineered
article-version (VoR) Version of Record
Heterotopic ossification (HO) is frequently seen in patients with spinal injuries. Therefore, this study aimed to characterize the association of HO with ankylosing spondylitis (AS) through gene expression profiling. The human transcriptomic datasets
Publikováno v:
Zhejiang Da Xue Xue Bao Yi Xue Ban
Proteasome is the eukaryotic organelle responsible for degradation of short-lived proteins and involved in maintaining cellular protein homeostasis. It has been reported that during the occurrence and development of hepatocellular carcinoma (HCC), th
Autor:
Moisés Wasserman, Luisa F. Prada, Magda E. Alvarado, Jenny J. Chaparro-Gutiérrez, Eliana Calvo
Publikováno v:
Acta Tropica. 225:106183
Giardia is a parasite whose life cycle is composed of two stages: replicative trophozoites, responsible for the symptoms of the disease, and infective cysts, resistant to adverse environments outside of hosts. Proteasomes are multicatalytic peptidase
Publikováno v:
Journal of Molecular Biology. 429:3525-3545
Three deubiquitinating enzymes-Rpn11, Usp14, and Uch37-are associated with the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin from substrates before they are translocated into the core particle to be degraded. Alt
Publikováno v:
Molecular Biology of the Cell
Proteasome assembly utilizes multiple dedicated assembly chaperones and is regulated by signaling pathways that respond to diverse stress conditions. To discover new factors influencing proteasome base assembly, we screened a tiled high-copy yeast ge
Autor:
Giacomo Lettini, Franca Esposito, Danilo Swann Matassa, Vittorio Simeon, Matteo Landriscina, Giuseppe Pannone, Maria Rosaria Amoroso, Francesca Maddalena, Filomena Nozza, Pantaleo Bufo, Carmela Mazzoccoli, Annamaria Piscazzi, Elvira Lopes, Valentina Condelli, Lorenza Sisinni, Valeria Li Bergolis
Publikováno v:
The Journal of Pathology. 243:123-134
Regulation of tumour cell proliferation by molecular chaperones is still a complex issue. Here, the role of the HSP90 molecular chaperone TRAP1 in cell cycle regulation was investigated in a wide range of human breast, colorectal, and lung carcinoma
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Nature Communications
The proteasome holoenzyme is the major non-lysosomal protease; its proteolytic activity is essential for cellular homeostasis. Thus, it is an attractive target for the development of chemotherapeutics. While the structural basis of core particle (CP)
Autor:
Andreas Martin, Jared A.M. Bard
Publikováno v:
Methods in Molecular Biology ISBN: 9781493987054
The 26S proteasome is the major regulated protease in eukaryotes and is responsible for degrading ubiquitinated substrates. It consists of a barrel-shaped 20S core peptidase and one or two 19S regulatory particles, which recognize, unfold, and transl
Autor:
Yinghua Liu, Qian Wu, Quan Yi, Qin Xue, Jia-Hui Tian, Sujuan Li, Jiandong Luo, Kui-Xiang Chen, Mubarak Rekep, Qing Xiao, Gen-Shui Zhang, Gui-Ping Zhang, Wei Wei
Publikováno v:
Cardiovascular drugs and therapy. 32(1)
Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this study, a mechanism related to proteasome-glycogen synthesis kinase 3 (GSK-3) wa
Publikováno v:
Biological reviews of the Cambridge Philosophical Society. 93(4)
Proteasomes are responsible for the turnover of most cellular proteins, and thus are critical to almost all cellular activities. A substrate entering the proteasome must first bind to a substrate receptor. Substrate receptors can be classified as ubi