Zobrazeno 1 - 10 of 104 217 pro vyhledávání: '"Protease inhibitors"'
1
Akademický článek
Investigating the antiviral therapeutic potentialities of marine polycyclic lamellarin pyrrole alkaloids as promising inhibitors for SARS-CoV-2 and Zika main proteases (Mpro).
Autor: Pereira F; LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, Caparica, Portugal., Bedda L; Drug Design and Discovery Laboratory, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., Tammam MA; Department of Biochemistry, Faculty of Agriculture, Fayoum University, Fayoum, Egypt., Alabdullah AK; Crop Genetics Department, John Innes Centre, Colney, Norwich, UK., Arafa R; Drug Design and Discovery Laboratory, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., El-Demerdash A; Division of Organic Chemistry, Department of Chemistry, Faculty of Sciences, Mansoura University, Mansoura, Egypt.; Department of Biochemistry and Metabolism, the John Innes Centre, Norwich Research Park, Norwich, UK.
Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 May; Vol. 42 (8), pp. 3983-4001. Date of Electronic Publication: 2023 May 26.
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2
Akademický článek
Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Autor: Barton LS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States. Electronic address: linda.s.barton@gsk.com., Callahan JF; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Cantizani J; GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Concha NO; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Cotillo Torrejon I; GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Goodwin NC; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Joshi-Pangu A; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Kiesow TJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., McAtee JJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Mellinger M; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Nixon CJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Padrón-Barthe L; GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Patterson JR; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Pearson ND; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Pouliot JJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Rendina AR; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Buitrago Santanilla A; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Schneck JL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Sanz O; GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Thalji RK; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Ward P; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., Williams SP; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States., King BW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, United States.
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Feb 15; Vol. 100, pp. 117618. Date of Electronic Publication: 2024 Jan 29.
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3
Akademický článek
Weight gain following switch to integrase inhibitors from non-nucleoside reverse transcriptase or protease inhibitors in people living with HIV in the United States: analyses of electronic medical records and prescription claims.
Autor: Tse J; Real World Solutions, IQVIA, Durham, NC, USA., Prajapati G; Merck & Co., Inc, Rahway, NJ, USA., Zhao X; Real World Solutions, IQVIA, Durham, NC, USA., Near AM; Real World Solutions, IQVIA, Durham, NC, USA., Kumar PN; Georgetown University Medical Center, Washington, DC, USA.
Publikováno v: Current medical research and opinion [Curr Med Res Opin] 2023 Sep; Vol. 39 (9), pp. 1237-1246. Date of Electronic Publication: 2023 Aug 10.
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4
Akademický článek
Rational design, synthesis and pharmacological characterization of novel aminopeptidase A inhibitors.
Autor: Balavoine F; Quantum Genomics, 6 rue Cambacérès, F-75008 Paris, France. Electronic address: fabrice.balavoine@gmail.com., Compere D; Quantum Genomics, 6 rue Cambacérès, F-75008 Paris, France; Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Collège de France, Center for Interdisciplinary Research in Biology (CIRB), INSERM U1050/CNRS UMR7241, 11 place Marcelin Berthelot, F-75005 Paris, France., Miege F; Edelris, Bâtiment Bioserra 1 60 av Rockefeller, F-69003 Lyon, France., De Mota N; Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Collège de France, Center for Interdisciplinary Research in Biology (CIRB), INSERM U1050/CNRS UMR7241, 11 place Marcelin Berthelot, F-75005 Paris, France., Keck M; Quantum Genomics, 6 rue Cambacérès, F-75008 Paris, France; Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Collège de France, Center for Interdisciplinary Research in Biology (CIRB), INSERM U1050/CNRS UMR7241, 11 place Marcelin Berthelot, F-75005 Paris, France., Fer M; Edelris, Bâtiment Bioserra 1 60 av Rockefeller, F-69003 Lyon, France., Christen A; Edelris, Bâtiment Bioserra 1 60 av Rockefeller, F-69003 Lyon, France., Martin E; Edelris, Bâtiment Bioserra 1 60 av Rockefeller, F-69003 Lyon, France., Roche D; Edelris, Bâtiment Bioserra 1 60 av Rockefeller, F-69003 Lyon, France., Llorens-Cortes C; Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Collège de France, Center for Interdisciplinary Research in Biology (CIRB), INSERM U1050/CNRS UMR7241, 11 place Marcelin Berthelot, F-75005 Paris, France. Electronic address: c.llorens-cortes@college-de-france.fr., Rodeschini V; Edelris, Bâtiment Bioserra 1 60 av Rockefeller, F-69003 Lyon, France. Electronic address: vincent.rodeschini@edelris.com.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 15; Vol. 113, pp. 129940. Date of Electronic Publication: 2024 Sep 02.
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5
Akademický článek
Discovery of Fluorescent Naturally-Occurring Inhibitor of SARS-CoV-2 Main Protease by AIE Fluorescent Probe.
Autor: Lin H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical sciences, Beijing, 100050, China., Zhang CJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical sciences, Beijing, 100050, China.
Publikováno v: ChemMedChem [ChemMedChem] 2024 Nov 04; Vol. 19 (21), pp. e202400311. Date of Electronic Publication: 2024 Sep 12.
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6
Akademický článek
Synthesis, in vitro and in silico evaluation of gallamide and selenogallamide derivatives as inhibitors of the SARS-CoV-2 main protease.
Autor: Carvalho MAG; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Souza GB; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Tizziani T; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Pontes CLM; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Dambrós BP; Department of Microbiology, Immunology and Parasitology, CCB, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Sousa NF; Department of Chemistry, Center for Exact and Natural Sciences, Universidade Federal de Paraíba, Campus I, João Pessoa, Paraíba, Brazil., Scotti MT; Department of Chemistry, Center for Exact and Natural Sciences, Universidade Federal de Paraíba, Campus I, João Pessoa, Paraíba, Brazil., Steindel M; Department of Microbiology, Immunology and Parasitology, CCB, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Braga AL; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Sandjo LP; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil., Assis FF; Department of Chemistry, CFM, Universidade Federal de Santa Catarina, Campus Universitario-Trindade, Florianópolis, Santa Catarina, Brazil.
Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Nov; Vol. 357 (11), pp. e2400253. Date of Electronic Publication: 2024 Aug 15.
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7
Akademický článek
Discovery of a Highly Promising Disulfide Derivative Scaffold as Inhibitor of SARS-CoV-2 Main Protease.
Autor: Xu YS; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China., Xiang Y; College of Physical Education, Yan'an University, Yan'an, 716000, PR China., Zhai L; Engineering Research Center of Advanced Ferroelectric Functional Materials, Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, PR China., Chen C; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China., Wu XR; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China., Chen WY; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China., Liu L; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China., Zhao MH; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China., Liu XL; School of medicine, Yan'an University, Yan'an, 716000, PR China., Yang KW; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, PR China.
Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Nov; Vol. 21 (11), pp. e202401034. Date of Electronic Publication: 2024 Sep 25.
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8
Akademický článek
Quantum mechanical analysis of newly synthesized HIV-1 protease inhibitors: evaluation of wild-type and resistant strain binding interactions.
Autor: Silva GVR; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande no Norte, 59072-970, Natal-RN, Brazil. umbertofulco@gmail.com., Ramos Reiniger KA; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande no Norte, 59072-970, Natal-RN, Brazil. umbertofulco@gmail.com., de Lima Menezes G; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande no Norte, 59072-970, Natal-RN, Brazil. umbertofulco@gmail.com., Bezerra KS; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande no Norte, 59072-970, Natal-RN, Brazil. umbertofulco@gmail.com.; Applied Physics Department, University of Campinas, Campinas, São Paulo 13083-859, Brazil., Galvão DS; Applied Physics Department, University of Campinas, Campinas, São Paulo 13083-859, Brazil., Saivish MV; Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, Brazil., da Silva RA; Núcleo Colaborativo de Biosistemas, Universidade Federal de Jataí, Jataí 75801-615, Brazil., Akash S; Department of Pharmacy, Daffodil International University, Sukrabad, Dhaka, 1207, Bangladesh., Tayyeb JZ; Department of Clinical Biochemistry, College of Medicine, University of Jeddah, Jeddah 23890, Saudi Arabia., Oliveira JIN; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande no Norte, 59072-970, Natal-RN, Brazil. umbertofulco@gmail.com., Fulco UL; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande no Norte, 59072-970, Natal-RN, Brazil. umbertofulco@gmail.com.
Publikováno v: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2024 Oct 30; Vol. 26 (42), pp. 26748-26764. Date of Electronic Publication: 2024 Oct 30.
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9
Akademický článek
Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors.
Autor: Kovalevsky A; Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States., Aniana A; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, United States., Ghirlando R; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0540, United States., Coates L; Second Target Station, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States., Drago VN; Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States., Wear L; Department of Natural Sciences, Tennessee Wesleyan University, Athens, Tennessee 37303, United States., Gerlits O; Department of Natural Sciences, Tennessee Wesleyan University, Athens, Tennessee 37303, United States., Nashed NT; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, United States., Louis JM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0520, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 24; Vol. 67 (20), pp. 18478-18490. Date of Electronic Publication: 2024 Oct 07.
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10
Akademický článek
Insights into the Main Protease of SARS-CoV-2: Thermodynamic Analysis, Structural Characterization, and the Impact of Inhibitors.
Autor: Butalewicz JP; Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States., Sipe SN; Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States., Juetten KJ; Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States., James VK; Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States., Kim K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States., Zhang YJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States., Meek TD; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States., Brodbelt JS; Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Publikováno v: Analytical chemistry [Anal Chem] 2024 Oct 08; Vol. 96 (40), pp. 15898-15906. Date of Electronic Publication: 2024 Sep 25.
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