Zobrazeno 1 - 10 of 2 809 pro vyhledávání: '"Protease inhibitor (biology)"'
1
Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity
Autor: Yu-Wen Lin, Jehng-Kang Wang, Michael D. Johnson, Yi-Ying Wu, Hou-Ping Sytwo, Chen-Yong Lin, Kacy Yang, Yi-Lin Chiu, Robert B. Barndt, Amy Cheng, Khee-Siang Chan
Publikováno v: Genes & Diseases. 9:1049-1061
The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2 can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd1642c8dfd1304cfa79b4e708f158
https://doi.org/10.1016/j.gendis.2020.12.001
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2
Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes
Autor: Sari S. Hannila, Tinsley Claire Douglas
Publikováno v: Biochemistry and Cell Biology. 100:1-8
Secretory leukocyte protease inhibitor (SLPI) is a small but powerful member of the serine protease inhibitor family, which includes proteins such as elafin and α1-antitrypsin. These proteins all have similar structures and antiprotease abilities, b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec8e7cc26dab90c04271ccc429470c8
https://doi.org/10.1139/bcb-2021-0284
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3
Biological Characterization and Preliminary Crystallization: A Step Towards the Use of Novel Allium sativum Protease Inhibitor as a Potential Therapeutic Drug
Autor: Romana Parveen, Sumbul Afreen, Tooba Naz Shamsi, Tasneem Fatma, Sadaf Fatima, Manish Kumar
Publikováno v: Current Enzyme Inhibition. 17:196-203
Background: Garlic, being a well-known medicinal plant, is the most commonly used culinary spice worldwide. Investigation of protease inhibitor isolated from garlic leads to a promising contender in pharmacognostic and pharmacological studies. Object
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcd3fe4d5638f268d3b2507912d977c4
https://doi.org/10.2174/1573408017666210809104744
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4
HIV-1 Gag Non-Cleavage Site PI Resistance Mutations Stabilize Protease/Gag Substrate Complexes In Silico via a Substrate-Clamp
Autor: Gary S. Laco
Publikováno v: BioChem, Vol 1, Iss 15, Pp 190-209 (2021)
BioChem
Volume 1
Issue 3
Pages 15-209
HIV-1 protease active site inhibitors are a key part of antiretroviral therapy, though resistance can evolve rendering therapy ineffective. Protease inhibitor resistance typically starts with primary mutations around the active site, which reduces in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d138316533445b39fc13a0879115d345
https://www.mdpi.com/2673-6411/1/3/15
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6
A Conserved Nonribosomal Peptide Synthetase in Xenorhabdus bovienii Produces Citrulline-Functionalized Lipopeptides
Autor: Jhe-Hao Li, Randy Hamchand, Joonseok Oh, Jason M. Crawford, Wooyoung Cho
Publikováno v: J Nat Prod
The entomopathogenic bacterium Xenorhabdus bovienii exists in a mutualistic relationship with nematodes of the genus Steinernema. Free-living infective juveniles (IJs) of Steinernema prey on insect larvae and regurgitate X. bovienii within the hemoco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730a3c81d6ea9cf7acdc066446496be6
https://doi.org/10.1021/acs.jnatprod.1c00573
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7
Mechanistic Insights into the Inhibition of SARS-CoV-2 Main Protease by Clovamide and Its Derivatives: In Silico Studies
Autor: Naike Ye, Miriam Rossi, Francesco Caruso
Publikováno v: Biophysica, Vol 1, Iss 28, Pp 377-404 (2021)
Biophysica
Volume 1
Issue 4
Pages 28-404
The novel coronavirus SARS-CoV-2 Main Protease (Mpro) is an internally encoded enzyme that hydrolyzes the translated polyproteins at designated sites. The protease directly mediates viral replication processes
hence, a promising target for drug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dcf3479fa523a47b4cf62d82887c2e
https://doi.org/10.3390/biophysica1040028
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8
In silico SCREENING OF Ziziphus spina-christi (L.) Desf. AND Strychnos ligustrine COMPOUNDS AS A PROTEASE INHIBITOR OF SARS-COV-2
Autor: Uthami Syabillawati, Esti Mulatsari, Novi Yantih, Wahono Sumaryono
Publikováno v: Journal of Experimental Biology and Agricultural Sciences. 9:S208-S214
Diseases caused by the coronavirus have become an important concern in early 2020. The coronavirus is a new type of virus that is included in the SARS-CoV-2 group. One of the possible mechanisms of SARS-CoV-2 inhibition involves protease receptors in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35f03a1a964918a3470a8b2c8e427820
https://doi.org/10.18006/2021.9(spl-2-icopmes_2020).s208.s214
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9
In silico analysis of marine natural product from sponge (Clathria Sp.) for their activity as inhibitor of SARS-CoV-2 Main Protease
Autor: Fatmasari Siharis, Dwi Syah Fitra Ramadhan, Taufik Muhammad Fakih, Syawal Abdurrahman, Muhammad Isrul
Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:11526-11532
The target for COVID-19 has been successfully crystallized along with its inhibitor, named SARS-CoV-2 main protease, making it easier for drug discovery and development. Sponge (Clathria Sp.) is a marine species that can be found in Indonesia and has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::457dca4fedbb97dae2fc332e3d2dc516
https://doi.org/10.1080/07391102.2021.1959405
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10
Effects of inhibitors on the protease profiles and degradation of activated Cry toxins in larval midgut juices of Cnaphalocrocis medinalis (Lepidoptera: Pyralidae)
Autor: Zhi-hong Wu, Ya-jun Yang, Hong-xing Xu, Lu Zhongxian
Publikováno v: Journal of Integrative Agriculture, Vol 20, Iss 8, Pp 2195-2203 (2021)
Midgut juice plays an important role in food digestion and detoxification in insects. In order to understand the potential of midgut juice of Cnaphalocrocis medinalis (Guenee) to degrade Bt proteins, the enzymatic activity of midgut juice and its deg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d6690654f91e79ebd69377338a337d
https://doi.org/10.1016/s2095-3119(20)63316-0
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