PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks

Autor: Maria Cristina Paz-Cabrera, Pablo Huertas, Cintia Checa-Rodríguez, Juan Ramon Hernandez-Fernaud, Raimundo Freire, Haico van Attikum, Ignacio Alonso-de Vega, Magdalena B. Rother, Wouter W. Wiegant, Veronique A. J. Smits

Publikováno v: Nucleic Acids Research, 48(9), 4915-4927. OXFORD UNIV PRESS
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defdbae8ae82a6c0c87aaa8693a0b914
https://doi.org/10.1093/nar/gkaa196

A importância de reconhecer e caracterizar mulheres brasileiras com a síndrome do câncer de mama e ovário hereditários

Autor: Souza, Alessandra Borba Anton de

Publikováno v: Biblioteca Digital de Teses e Dissertações da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS

O câncer de mama é o mais incidente na população feminina, excetuando-se os casos de câncer de pele. Calcula-se que 20 a 30% dos casos sejam de origem familial e os outros 70 a 80% sejam esporádicos. Pacientes que apresentam critérios para neo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::68b1eefb8625520977154aeaeb29edb5

Large Genomic Rearrangements of BRCA1 and BRCA2 among Patients Referred for Genetic Analysis in Galicia (NW Spain): Delimitation and Mechanism of Three Novel BRCA1 Rearrangements

Autor: Ana Blanco, Angel Carracedo, Laura Fachal, Marta Santamariña, Ana Vega

Publikováno v: RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
PLoS ONE, Vol 9, Iss 3, p e93306 (2014)
PLoS ONE
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

In the Iberian Peninsula, which includes mainly Spain and Portugal, large genomic rearrangements (LGRs) of BRCA1 and BRCA2 have respectively been found in up to 2.33% and 8.4% of families with hereditary breast and/or ovarian cancer (HBOC) that lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08aa4dc032ef36a3a083c33be9e0ce0
https://hdl.handle.net/10347/21807

Breast Cancer 1 (BrCa1) May Be behind Decreased Lipogenesis in Adipose Tissue from Obese Subjects

Autor: Eva García-Santos, Bartomeu Ruiz, Francisco J. Tinahones, Dolores Mayas, Francisco J. Ortega, Gema Frühbeck, José Manuel Fernández-Real, José Ignacio Rodríguez-Hermosa, Wifredo Ricart, María Gómez-Serrano, José María Moreno-Navarrete, Belén Peral

Publikováno v: PLoS ONE
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE, Vol 7, Iss 5, p e33233 (2012)

This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.
[Context]: Expression and activity of the main lipogenic enzymes is paradoxically decreased in obesity, but the mechanisms behind th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22175c54c5badd2e6d9e60aaf6071782
http://europepmc.org/articles/PMC3364252

Inactivación del cromosoma-X y BRCA1. Exploración con RNAi

Autor: Lina Marcela Barrera Arenas, David Aristizabal Corrales, Mauricio Camargo Guerrero

Publikováno v: Iatreia, Vol 23, Iss 4-S (2010)

La inactivación del cromosoma X es un evento epigenético sorprendente que suprime muchos genes en uno de los dos cromosomas X en los mamíferos hembras. La erencia somática de esta inactivación depende de su mantenimiento que involucra un complej

Externí odkaz: https://doaj.org/article/e68cb6c9a13c4c0e8dd5ac4c79a4d722