Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability

Autor: Nikitin, Evgeny S., Postnikova, Tatiana Y., Proskurina, Elena Y., Borodinova, Anastasia A., Ivanova, Violetta, Roshchin, Matvey V., Smirnova, Maria P., Kelmanson, Ilya, Belousov, Vsevolod V., Balaban, Pavel M., Zaitsev, Aleksey V.

Publikováno v: Gene Therapy; March 2024, Vol. 31 Issue: 3-4 p144-153, 10p

Optogenetic Low-Frequency Stimulation of Principal Neurons, but Not Parvalbumin-Positive Interneurons, Prevents Generation of Ictal Discharges in Rodent Entorhinal Cortex in an In Vitro 4-Aminopyridine Model.

Autor: Proskurina EY; Almazov National Medical Research Centre, 2 Akkuratova Street, 197341 St. Petersburg, Russia.; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 44 Toreza Prospekt, 194223 St. Petersburg, Russia., Chizhov AV; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 44 Toreza Prospekt, 194223 St. Petersburg, Russia.; Computational Physics Laboratory, Ioffe Institute, 26 Polytekhnicheskaya Street, 194021 St. Petersburg, Russia.; MathNeuro Team, Inria Centre at Universite Cote d'Azur, 06902 Sophia Antipolis, France., Zaitsev AV; Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 44 Toreza Prospekt, 194223 St. Petersburg, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 22; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 22.