Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis.

Autor: Fan L; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA., Sweet DR; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA., Prosdocimo DA; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; The Webb Law Firm, Pittsburgh, Pennsylvania, USA., Vinayachandran V; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Chan ER; Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA., Zhang R; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Lu Y; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Charles River Laboratories, Ashland, Ohio, USA., Keerthy KS; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Booth CE; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Departments of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Jain MK; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Feb 15; Vol. 131 (4).

Leukocyte integrin signaling regulates FOXP1 gene expression via FOXP1-IT1 long non-coding RNA-mediated IRAK1 pathway.

Autor: Shi C; Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: can.shi@case.edu., Miley J; Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Nottingham A; Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Morooka T; Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Prosdocimo DA; Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Simon DI; Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Publikováno v: Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2019 Apr; Vol. 1862 (4), pp. 493-508. Date of Electronic Publication: 2019 Mar 02.

KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability.

Autor: Jiang W; Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Hexi District, Huanhuxi Road, Tianjin, 300060, China., Liu L; Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Hexi District, Huanhuxi Road, Tianjin, 300060, China., Wang M; Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Hexi District, Huanhuxi Road, Tianjin, 300060, China., Li X; Department of Pancreatic Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China., Zhou T; Department of Pancreatic Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China., Hou X; Department of Pancreatic Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China., Qiao L; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences of Tianjin Medical University, Tianjin, China., Chen C; Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Hexi District, Huanhuxi Road, Tianjin, 300060, China., Zuo D; Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Hexi District, Huanhuxi Road, Tianjin, 300060, China., Liu J; Department of Breast Oncoplastic Surgery, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China., Ren L; Department of Clinical Laboratory, Key Laboratory of Cancer Prevention and Therapy, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Hexi District, Huanhuxi Road, Tianjin, 300060, China. Ren1999li@163.com.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Oct 05; Vol. 81 (1), pp. 417. Date of Electronic Publication: 2024 Oct 05.

Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.

Autor: Sugi K; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Hsieh PN; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Pathology, Case Western Reserve University, Cleveland, OH, United States of America., Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center, Departments of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America., Shelkay S; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Moroney B; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Baadh P; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Haynes B; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Pophal M; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Fan L; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Pathology, Case Western Reserve University, Cleveland, OH, United States of America., Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center, Departments of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America., Prosdocimo DA; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America., Jain MK; Case Cardiovascular Research Institute and Harrington Heart & Vascular Institute, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.; Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH, United States of America.

Publikováno v: PloS one [PLoS One] 2018 Feb 06; Vol. 13 (2), pp. e0192376. Date of Electronic Publication: 2018 Feb 06 (Print Publication: 2018).

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.

Autor: Hsieh PN; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA.; Department of Pathology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA., Zhou G; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Yuan Y; Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA., Zhang R; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Prosdocimo DA; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Sangwung P; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA.; Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA., Borton AH; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA.; Department of Pathology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA., Boriushkin E; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Hamik A; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Fujioka H; Electron Microscopy Facility, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Department of Pharmacology, Center for Mitochondrial Diseases, 10900 Euclid Avenue, Cleveland, OH, 44106, USA., Fealy CE; Department of Biomedical Sciences, Kent State University, Cunningham Hall, Kent, OH, 44242, USA., Kirwan JP; Department of Pathobiology, Lerner Research Institute, 9500 Euclid Avenue, Cleveland Clinic, Cleveland, OH, 44195, USA.; Metabolic Translational Research Center, Cleveland Clinic Foundation, 9500 Euclid Avenue/ M83-02, Cleveland, OH, 44195, USA., Peters M; Department of Biology, Oberlin College, 119 Woodland Street, Oberlin, OH, 44074, USA., Lu Y; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Liao X; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Ramírez-Bergeron D; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA., Feng Z; Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA. zxf17@case.edu., Jain MK; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA. mxj84@case.edu.; Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 2103 Cornell Road, Cleveland, OH, 44106, USA. mxj84@case.edu.

Publikováno v: Nature communications [Nat Commun] 2017 Oct 13; Vol. 8 (1), pp. 914. Date of Electronic Publication: 2017 Oct 13.