Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Prosanta K. Singha"'
Autor:
Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kälvälä, Eemeli Moisio, Juha R. Savinainen, Jarmo T. Laitinen
Publikováno v:
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)
Abstract Background Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP
Externí odkaz:
https://doaj.org/article/39a46c768cee473fbdc8573d58d1d4d5
Autor:
Thomas Wirth, Eemeli Moisio, Kirsi Rilla, Paulina Kasperkiewicz, Prosanta K. Singha, Markku Varjosalo, Sanna Pasonen-Seppänen, Jarmo T. Laitinen, Sara Kälvälä, Marcin Drag, Juha R. Savinainen, Hermina Jakupović, Laura E. Edgington-Mitchell, Niina Aaltonen, Haritha Samaranayake
Publikováno v:
Biological Procedures
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)
Background Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc07b4597e8c09e23c74070010b5b96d
http://hdl.handle.net/10138/317397
http://hdl.handle.net/10138/317397
Autor:
Aaltonen, Niina, Prosanta K. Singha, Jakupović, Hermina, Wirth, Thomas, Haritha Samaranayake, Pasonen-Seppänen, Sanna, Rilla, Kirsi, Varjosalo, Markku, Edgington-Mitchell, Laura E., Kasperkiewicz, Paulina, Drag, Marcin, Kälvälä, Sara, Moisio, Eemeli, Savinainen, Juha R., Laitinen, Jarmo T.
Additional file 1 : Figure S1. Activity-based protein profiling (ABPP) and the power of this approach to unveil SH activity in glioma. Figure S2. Characteristics of the rat BT4C gliosarcoma model. Figure S3. Coronal plane MRI images of glioma and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a766725a3de199f2fcb3244d941a30b5
Autor:
Haritha Samaranayake, Marcin Drag, Sanna Pasonen-Seppänen, Sara Kälvälä, Laura E. Edgington-Mitchell, Jarmo T. Laitinen, Eemeli Moisio, Markku Varjosalo, Prosanta K. Singha, Paulina Kasperkiewicz, Juha R. Savinainen, Hermina Jakupović, Niina Aaltonen, Kirsi Rilla, Thomas Wirth
Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a12dc98db7aac398bba304bd842d700
Autor:
Juha R. Savinainen, Tapio Nevalainen, Prosanta K. Singha, Antti Poso, Arun Kumar Tonduru, Mahadeo R. Patil, Tuomo Laitinen, Kiira Mäklin, Taina Vihavainen, Jarmo T. Laitinen
Publikováno v:
European Journal of Pharmaceutical Sciences. 149:105321
De novo synthesis of fatty acids is essential to maintain intensive proliferation of cancer cells. Unlike normal cells that utilize food-derived circulating lipids for their fuel, cancer cells rely on heightened lipogenesis irrespective of exogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330b62ce2895bd46c43f437d80821e4a
https://doi.org/10.1016/j.ejps.2020.105321
https://doi.org/10.1016/j.ejps.2020.105321
Autor:
Tatu Pantsar, Tuomo Laitinen, Jarmo T. Laitinen, Igor O. Koshevoy, Prosanta K. Singha, Tapio Nevalainen, Sanna Pasonen-Seppänen, Juha M.A. Niskanen, Antti Poso, Jukka Leppänen, Juha R. Savinainen
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 107
Inhibition of Autotaxin (ATX) is a potential treatment strategy for several diseases, including tumors with elevated ATX-lysophosphatidic acid (LPA) signaling. Combining structure-based virtual screening together with hen egg-white Autotaxin (ewATX)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21095f7229739486821f2bed4db0442
https://pubmed.ncbi.nlm.nih.gov/28687529
https://pubmed.ncbi.nlm.nih.gov/28687529
Publikováno v:
RNA biology. 12(11)
Many splicing regulators bind to their own pre-mRNAs to induce alternative splicing that leads to formation of unstable mRNA isoforms. This provides an autoregulatory feedback mechanism that regulates the cellular homeostasis of these factors. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108f14a2fa725d2513b4f4af4de99f0e
https://pubmed.ncbi.nlm.nih.gov/26479860
https://pubmed.ncbi.nlm.nih.gov/26479860
Autor:
Aaltonen, Niina1 (AUTHOR), Singha, Prosanta K.1 (AUTHOR), Jakupović, Hermina1 (AUTHOR), Wirth, Thomas2 (AUTHOR), Samaranayake, Haritha2 (AUTHOR), Pasonen-Seppänen, Sanna1 (AUTHOR), Rilla, Kirsi1 (AUTHOR), Varjosalo, Markku3 (AUTHOR), Edgington-Mitchell, Laura E.4,5,6 (AUTHOR), Kasperkiewicz, Paulina7 (AUTHOR), Drag, Marcin7 (AUTHOR), Kälvälä, Sara1 (AUTHOR), Moisio, Eemeli1 (AUTHOR), Savinainen, Juha R.1 (AUTHOR), Laitinen, Jarmo T.1 (AUTHOR) jarmo.laitinen@uef.fi
Publikováno v:
Biological Procedures Online. 3/15/2020, Vol. 22 Issue 1, p1-21. 21p.