Proprotein convertase subtilisin/Kexin type-9 (PCSK-9) inhibitors induced liver injury - a retrospective analysis

Autor: Yousuf Zafar, Yasar Sattar, Waqas Ullah, Sohaib Roomi, Mamoon-Ur- Rashid, Muhammad Shayan Khan, Laura Schmidt

Publikováno v: Journal of Community Hospital Internal Medicine Perspectives, Vol 10, Iss 1, Pp 32-37 (2020)

Background Proprotein convertase subtilisin/Kexin type 9 (PCSK-9) inhibitors induced liver dysfunction in patients with or without previous liver injury, and this is not well discussed in the previous literature. Methods A total sample of 202 patient

Externí odkaz: https://doaj.org/article/1dee3337d3474525b226fba2d63d1ef4

Proprotein convertase subtilisin/Kexin type-9 (PCSK-9) inhibitors induced liver injury - a retrospective analysis

Autor: Zafar, Yousuf, Sattar, Yasar, Ullah, Waqas, Roomi, Sohaib, Rashid, Mamoon-Ur, Khan, Muhammad Shayan, Schmidt, Laura

Publikováno v: Journal of Community Hospital Internal Medicine Perspectives
Journal of Community Hospital Internal Medicine Perspectives, Vol 10, Iss 1, Pp 32-37 (2020)

Background: Proprotein convertase subtilisin/Kexin type 9 (PCSK-9) inhibitors induced liver dysfunction in patients with or without previous liver injury, and this is not well discussed in the previous literature. Methods: A total sample of 202 patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2e7d4033ebd08aa35b8637895e7e9abe
http://europepmc.org/articles/PMC7034434

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene

Autor: Fairoozy, Roaa Hani, Cooper, Jackie, White, Jon, Giambartolomei, Claudia, Folkersen, Lasse Westergaard, Wannamethee, S. Goya, Jefferis, Barbara J., Whincup, Peter H., Ben-Shlomo, Yoav, Kumari, Meena, Kivimaki, Mika, Wong, Andrew, Hardy, Rebecca, Kuh, Diana, Gaunt, Tom R., Casas, Juan P., McLachlan, Stela, Price, Jackie F., Hingorani, Aroon D, Franco-Cereceda, Anders, Grewal, Thomas, Kalea, Anastasia Z., Humphries, Steve E

Publikováno v: Atherosclerosis
Fairoozy, R H, Cooper, J A, White, J, Giambartolomei, C, Folkersen, L, Wannamethee, S G, Jefferis, B J, Whincup, P H, Ben-shlomo, Y, Kumari, M, Kivimaki, M, Wong, A, Hardy, R, Kuh, D, Gaunt, T R, Casas, J P, McLachlan, S, Price, J, Hingorani, A D, Franco-Cereceda, A, Grewal, T & Kalea, A Z & Humphries, S E 2017, ' Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene ', Atherosclerosis . https://doi.org/10.1016/j.atherosclerosis.2017.04.010
Fairoozy, R H, Cooper, J A, White, J, Giambartolomei, C, Folkersen, L, Wannamethee, SG, Jefferis, B J, Whincup, P H, Ben-Shlomo, Y, Kumari, M, Kivimaki, M, Wong, A, Hardy, R, Kuh, D, Gaunt, T, Casas, JP, McLachlan, S, Price, J F, Hingorani, A D, Franco-Cereceda, A, Grewal, T, Kalea, A Z & Humphries, S E 2017, ' Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene ', Atherosclerosis, vol. 261, pp. 60-68 . https://doi.org/10.1016/j.atherosclerosis.2017.04.010
Fairoozy, R H, Cooper, J, White, J, Giambartolomei, C, Folkersen, L W, Wannamethee, S G, Jefferis, B J, Whincup, P H, Ben-Shlomo, Y, Kumari, M, Kivimaki, M, Wong, A, Hardy, R, Kuh, D, Gaunt, T R, Casas, J P, McLachlan, S, Price, J F, Hingorani, A D, Franco-Cereceda, A, Grewal, T, Kalea, A Z & Humphries, S E 2017, ' Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene ', Atherosclerosis, vol. 261, pp. 60-68 . https://doi.org/10.1016/j.atherosclerosis.2017.04.010

Background and aims Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein cho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::12829341174046f544e4e18f845321ce
http://europepmc.org/articles/PMC5446264

Effects of proprotein convertase subtilisin/kexin type-9 inhibitors on fatty liver

Autor: Venkat Nutalapati, Yousaf Zafar, Muhammad Shafiq, Timothy Walmann, Cheryl A. Gibson

Publikováno v: World Journal of Hepatology

BACKGROUND Many studies have investigated the progression of nonalcoholic fatty liver disease (NAFLD) and its predisposing risk factors, but the conclusions from these studies have been conflicting. More challenging is the fact that no effective trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5d7ba3029f2f36a1f1703961053029
https://pubmed.ncbi.nlm.nih.gov/33442452

Pathophysiology and treatment of atherosclerosis

Autor: Mathijs C. Bodde, Joop Jukema, S. C. Bergheanu

Publikováno v: Netherlands Heart Journal, 25(4), 231-242
Netherlands Heart Journal

Recent years have brought a significant amount of new results in the field of atherosclerosis. A better understanding of the role of different lipoprotein particles in the formation of atherosclerotic plaques is now possible. Recent cardiovascular cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c18583221fbc065e3c3589e61080e
https://doi.org/10.1007/s12471-017-0959-2