Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Properties of biomolecules"'
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110373- (2024)
Summary: Homologous recombination is initiated by the nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process. In the short-range step, the MRX (Mre11-Rad50-Xrs2) complex, together with Sae2, incise
Externí odkaz:
https://doaj.org/article/005a8cfcaad84c2196cb2a5f63050469
Autor:
Himangshu S. Bose
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110039- (2024)
Summary: Multiple metabolic events occur in mitochondria. Mitochondrial protein translocation from the cytoplasm across compartments depends on the amino acid sequence within the precursor. At the mitochondria associated-ER membrane, misfolding of a
Externí odkaz:
https://doaj.org/article/968f521c68304a32bc78b3ee5b4b93fd
Autor:
Siyuan Hao, Ye Jin Lee, Nadav Benhamou Goldfajn, Eduardo Flores, Jindayi Liang, Hannah Fuehrer, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Cai
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109927- (2024)
Summary: YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular conden
Externí odkaz:
https://doaj.org/article/93e023ecedcf4265b02598fc8193056d
Autor:
Jiaojiao Feng, Xiaoniao Chen, Runkuan Li, Yunxiao Xie, Xiuyan Zhang, Xiaoxiao Guo, Lianghui Zhao, Zhe Xu, Yifan Song, Jike Song, Hongsheng Bi
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110606- (2024)
Summary: The biological mechanisms underlying the development of myopia have not yet been completely elucidated. The retina is critical for visual signal processing, which primarily utilizes aerobic glycolysis to produce lactate as a metabolic end pr
Externí odkaz:
https://doaj.org/article/3b060de954a747408628368f33a8db96
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110605- (2024)
Summary: ATP-citrate lyase (ACLY) is a critical metabolic enzyme and promising target for drug development. The structure determinations of ACLY have revealed its homotetramer states with various subunit symmetries, but catalytic mechanism of ACLY te
Externí odkaz:
https://doaj.org/article/a8e9d2122aef4812861f84e69b52ca2d
Autor:
Sneha Paul, Mauricio A. Arias, Li Wen, Susan E. Liao, Jiacheng Zhang, Xiaoshu Wang, Oded Regev, Jingyi Fei
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109603- (2024)
Summary: RNA molecules often play critical roles in assisting the formation of membraneless organelles in eukaryotic cells. Yet, little is known about the organization of RNAs within membraneless organelles. Here, using super-resolution imaging and n
Externí odkaz:
https://doaj.org/article/34c8d8112954418f9da7dbd735943262
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
Autor:
Mi Young Son, Ondrej Belan, Mario Spirek, Jakub Cibulka, Fedor Nikulenkov, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Cristina Montagna, Tae Moon Kim, Lumir Krejci, Paul Hasty
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109524- (2024)
Summary: Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the BRC repeats to form filaments on single-stranded DNA and exon 27 (E
Externí odkaz:
https://doaj.org/article/9292610b2dda480b8b8912a6757729c2
Autor:
Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, 3rd, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109330- (2024)
Summary: Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-co
Externí odkaz:
https://doaj.org/article/7c9c5701df2748eb9bb1238451f24137
Autor:
Abigail Brewer, Gajanan Sathe, Billie E. Pflug, Rosemary G. Clarke, Thomas J. Macartney, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109302- (2024)
Summary: Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit. The full scope of PP2A
Externí odkaz:
https://doaj.org/article/f25d696fa64648859afd184fd61b5cbd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108883- (2024)
Summary: Mitochondria are dynamic organelles in cellular metabolism and physiology. Mitochondrial DNA (mtDNA) mutations are associated with a broad spectrum of clinical abnormalities. However, mechanisms underlying mtDNA mutations regulate intracellu
Externí odkaz:
https://doaj.org/article/eb708d73cd5b48f6af30efdd3a6daa46