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Vitamins D3 and K2 may partially counterbalance the detrimental effects of pentosidine in ex vivo human osteoblasts

Autor: Sanguineti, R., FIAMMETTA MONACELLI, Parodi, A., Furfaro, A. L., Borghi, R., Pacini, D., Pronzato, M. A., Odetti, P., Molfetta, L., Traverso, N.

Publikováno v: Web of Science
Scopus-Elsevier

Osteoporosis is a metabolic multifaceted disorder, characterized by insufficient bone strength. It has been recently shown that advanced glycation end products (AGEs) play a role in senile osteoporosis, through bone cell impairment and altered biomec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6df8ac947c860cffcf771c2c2d44f4d4
https://pubmed.ncbi.nlm.nih.gov/27655488

RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

Autor: Piras, S., Furfaro, A. L., Domenicotti, C., Traverso, N., Marinari, U. M., Pronzato, M. A., Nitti, M.

Publikováno v: Oxidative Medicine and Cellular Longevity.

RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=hindawi_publ::e731d11b6bd0ec5e13953f45ad6a6d27

A physiological role for amyloid beta in cyclic AMP-stimulated long term potentiation

Autor: Fedele, E, Puzzo, Daniela, Bruno, O, Canepa, E, Gardella, E, Rivera, D, Privitera, L, Domenicotti, C, Marengo, B, Marinari, U, Palmeri, A, Arancio O, Pronzato M., Ricciarelli, R.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4731::eb1567b20aee6e6b59ce909fbe484bce
http://hdl.handle.net/20.500.11769/56708

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

Autor: Bruno, Olga, Fedele, Ernesto, Prickaerts, Jos, Parker, L, Canepa, E, Brullo, C, Cavallero, A, Gardella, E, Balbi, A, Domenicotti, C, Bollen, Eva, Gijselaers, Jérôme, Vanmierlo, Tim, Erb, K, Limebeer, C, Argellati, F, Marinari, U, Pronzato, M, Ricciarelli, R

Publikováno v: British Journal of Pharmacology, 164(8), 2054-2063. Wiley
British Journal of Pharmacology, 164(8), 2054-2063. Wiley-Blackwell
Bruno, O, Fedele, E, Prickaerts, J, Parker, L, Canepa, E, Brullo, C, Cavallero, A, Gardella, E, Balbi, A, Domenicotti, C, Bollen, E, Gijselaers, J, Vanmierlo, T, Erb, K, Limebeer, C, Argellati, F, Marinari, U, Pronzato, M & Ricciarelli, R 2011, ' GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses ', British Journal of Pharmacology, vol. 164, no. 8, pp. 2054-2063 . https://doi.org/10.1111/j.1476-5381.2011.01524.x

Strategies designed to enhance cerebral cAMP have been proposed as symptomatic treatments to counteract cognitive deficits. However, pharmacological therapies aimed at reducing PDE4, the main class of cAMP catabolizing enzymes in the brain, produce s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f2bbad6b22ac76746448d1791e8c75b2
https://cris.maastrichtuniversity.nl/en/publications/aec35482-607a-4177-9975-b4b9816f219f