Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Promoter capture Hi-C"'
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Long-range interactions between promoters and cis-regulatory elements, such as enhancers, play critical roles in gene regulation. However, the role of three-dimensional (3D) chromatin structure in orchestrating changes in transcri
Externí odkaz:
https://doaj.org/article/8e7b8f44371a47dd947503c7a54a2bac
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Genome sequencing has revealed over 300 million genetic variations in human populations. Over 90% of variants are single nucleotide polymorphisms (SNPs), the remainder include short deletions or insertions, and small numbers of structural variants. H
Externí odkaz:
https://doaj.org/article/a1a0157e13b7444a9022c9b749de2d9a
Autor:
Kyukwang Kim, Inkyung Jung
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3149-3159 (2021)
Hi-C and capture Hi-C have greatly advanced our understanding of the principles of higher-order chromatin structure. In line with the evolution of the Hi-C protocols, there is a demand for an advanced computational method that can be applied to the v
Externí odkaz:
https://doaj.org/article/9cc9f18a49ad4e64b89cbafd585917ed
Akademický článek
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Autor:
Paula Freire-Pritchett, Stefan Schoenfelder, Csilla Várnai, Steven W Wingett, Jonathan Cairns, Amanda J Collier, Raquel García-Vílchez, Mayra Furlan-Magaril, Cameron S Osborne, Peter Fraser, Peter J Rugg-Gunn, Mikhail Spivakov
Publikováno v:
eLife, Vol 6 (2017)
Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-re
Externí odkaz:
https://doaj.org/article/6b57a130ecbc478aaa570feb12bd03e6
Publikováno v:
The Journal of Biological Chemistry
Adipose tissue dysfunction is a hallmark of obesity and contributes to obesity-related sequelae such as metabolic complications and insulin resistance. Compelling evidence indicates that adipose-tissue-specific gene expression is influenced by gene i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a354fdbe9790ca2862f5b66a6bd75279
http://europepmc.org/articles/PMC8561000
http://europepmc.org/articles/PMC8561000
Autor:
Ptasinska, Anetta, Pickin, Anna, Assi, Salam A., Chin, Paulynn Suyin, Ames, Luke, Avellino, Roberto, Gröschel, Stefan, Delwel, Ruud, Cockerill, Peter N., Osborne, Cameron S., Bonifer, Constanze
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3022-3031.e7 (2019)
Cell Reports
Cell Reports
Summary Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The t(8;21)(q22;q22) translocation generates the RUNX1-ETO fusion protein, which interferes with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fdc667228ac3a1b73fc7d99dac331a
http://www.sciencedirect.com/science/article/pii/S2211124719310800
http://www.sciencedirect.com/science/article/pii/S2211124719310800
Autor:
Thiecke, Michiel
All somatic cells within an organism contain the same genetic material, yet they display pronounced differences in function and morphology. Precise control of gene expression is of fundamental importance to allow cells to properly develop, maintain h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b7b85f66693a4064033ba9d75b7b5a
Akademický článek
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Autor:
Steven W. Wingett, Peter Fraser, Anne Segonds-Pichon, Paula Freire-Pritchett, Stefan Schoenfelder, Biola-Maria Javierre, Jonathan Cairns, Peter J. Rugg-Gunn, Clara Lopes Novo, Mayra Furlan-Magaril
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2615-2627 (2018)
Cell Reports
Cell Reports
Summary Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfaf4bf0e7e0cf324a63be935f4badd