Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Promoter Regions, Genetic/drug effects"'
Autor:
Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron
Publikováno v:
PLOS ONE, 17(2):e0263430. Public Library of Science
PLoS ONE, Vol 17, Iss 2 (2022)
PLoS ONE, Vol 17, Iss 2 (2022)
BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b91411d9a3772f259276cff0fffa8e
https://doi.org/10.1371/journal.pone.0263430
https://doi.org/10.1371/journal.pone.0263430
Autor:
Handoko, L., Kaczkowski, B., Hon, C. C., Lizio, M., Wakamori, M., Matsuda, T., Ito, T., Jeyamohan, P., Sato, Y., Sakamoto, K., Yokoyama, S., Kimura, Hiroshi, Minoda, A., Umehara, T.
Publikováno v:
Epigenetics. 13(No. 4):410-431
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed72bd1e8abe48f7e395d18d2ff5bbd
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100822105
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100822105
Autor:
Peter L. Hordijk, Igor Kovacevic, Saskia Scheij, Emma C. L. Cook, Noam Zelcer, Jessica K. Nelson, Anke Loregger, Huib Ovaa, Marten A. Hoeksema
Publikováno v:
Journal of biological chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Nelson, J K, Cook, E C L, Loregger, A, Hoeksema, M A, Scheij, S, Kovacevic, I, Hordijk, P L, Ovaa, H & Zelcer, N 2016, ' Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake ', Journal of Biological Chemistry, vol. 291, no. 9, pp. 4813-4825 . https://doi.org/10.1074/jbc.M115.698688
Journal of Biological Chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Nelson, J K, Cook, E C L, Loregger, A, Hoeksema, M A, Scheij, S, Kovacevic, I, Hordijk, P L, Ovaa, H & Zelcer, N 2016, ' Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake ', Journal of Biological Chemistry, vol. 291, no. 9, pp. 4813-4825 . https://doi.org/10.1074/jbc.M115.698688
Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedf0913ddcfb2603c43cc631340d66d
https://doi.org/10.1074/jbc.m115.698688
https://doi.org/10.1074/jbc.m115.698688
Autor:
Urs Scherrer, Pierre Dessen, Emrush Rexhaj, David Cerny, Stefano F. Rimoldi, Yves Allemann, Agim Pireva, Ariane Paoloni-Giacobino, Claudio Sartori
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
American Journal of Physiology. Heart and Circulatory Physiology, Vol. 309, No 7 (2015) pp. H1151-H1156
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
American Journal of Physiology. Heart and Circulatory Physiology, Vol. 309, No 7 (2015) pp. H1151-H1156
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Assisted reproductive technologies (ART) induce vascular dysfunction in humans and mice. In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13da4b294b26a37ea435a6982e6c7c9a
Autor:
Egbert K. O. Kruithof
Publikováno v:
Thrombosis and Haemostasis, Vol. 100, No 6 (2008) pp. 969-75
SummaryElevated plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1), also named serpin E1, are encountered in patients with thrombophilia, atherosclerosis, septicemia and the metabolic syndrome and may be associated with an increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c5572c39451308b1917989330ec39e
https://archive-ouverte.unige.ch/unige:2533
https://archive-ouverte.unige.ch/unige:2533
Publikováno v:
DNA and cell biology, 24(6), 381-7. United States (2005).
Cardiomyocytes are notoriously difficult to transfect using standard techniques unless viral vectors such as recombinant adenoviruses are used. Generation of recombinant adenoviruses is, however, a complex and time-consuming procedure and not possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0536125fa2a70dd6a85d48b9ffa87ec0
https://pubmed.ncbi.nlm.nih.gov/15941390
https://pubmed.ncbi.nlm.nih.gov/15941390
Publikováno v:
Biochemical and biophysical research communications. 274(2)
N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdb23f7c34dbbd414b17fc82b71a9c7
https://pubmed.ncbi.nlm.nih.gov/10913351
https://pubmed.ncbi.nlm.nih.gov/10913351
Publikováno v:
Journal of Biological Chemistry, Vol. 275, No 49 (2000) pp. 38921-8
Insulin-like growth factor (IGF-1) is a potent mitogen for vascular smooth muscle cells. Both IGF-1 and its receptor have been shown to be highly expressed in atherosclerotic lesions. Here we investigated whether part of the vasculoprotective propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7b0e291b436cd167f7f915e5f831ea08
https://archive-ouverte.unige.ch/unige:4473
https://archive-ouverte.unige.ch/unige:4473