Výsledky vyhledávání - "Promoter Regions, Genetic/*genetics"

Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer

Autor: Stian Knappskog, Merete Bjørnslett, Liv Beathe Gansmo, Lars J. Vatten, Pål Richard Romundstad, Kristian Hveem, Anne Dørum, Reham Helwa, Per Eystein Lønning, Mari K. Halle, Henrica M.J. Werner

Publikováno v: Biomarkers, 26(4), 302-308. Routledge/Taylor & Francis Group
Biomarkers

BACKGROUND: While large GWAS analyses have not found convincing associations between MDM2 promoter SNP55 and gynaecological cancers, SNP55 is in linkage disequilibrium with two other functional SNPs in the same promoter, likely to obscure association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef6d8de14b5bbf2ea0922cf11f07792
https://doi.org/10.1080/1354750x.2021.1891291

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Crucial role of Salmonella genomic island 1 master activator in the parasitism of IncC plasmids

Autor: Sébastien Rodrigue, Nicolas Rivard, Nicolas Carraro, Kévin T. Huguet, Romain Durand, Vincent Burrus

Publikováno v: Nucleic acids research, vol. 49, no. 14, pp. 7807-7824
Nucleic Acids Research

IncC conjugative plasmids and the multiple variants of Salmonella Genomic Island 1 (SGI1) are two functionally interacting families of mobile genetic elements commonly associated with multidrug resistance in the Gammaproteobacteria. SGI1 and its sibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f91b4705ae61cadd50ffc1dc0f45ea
https://serval.unil.ch/resource/serval:BIB_0F5DB3FD304D.P001/REF.pdf

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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

Autor: Andrea L. Johnstone, Helene Damhofer, Ole N. Jensen, Michael-Christopher Keogh, Aliaksandra Radzisheuskaya, Yingqian Zhan, Richard Koche, Vasily V. Grinev, Daria Shlyueva, Vladimir Gorshkov, Ronald C. Hendrickson, Kristian Helin, Sergey Kovalchuk, Keli L. Rodriguez, Pavel V. Shliaha

Publikováno v: Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M-C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Mol Cell

Summary Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in Drosophila, the functions of H4K16ac and two KAT8-containing protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe3ef6ffe7afe53ff13473b14698e7
https://portal.findresearcher.sdu.dk/da/publications/3c30878e-5994-484c-a75b-48f2827b2915

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HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

Autor: Kuo, F-C, Neville, MJ, Sabaratnam, R, Wesolowska-Andersen, A, Phillips, D, Wittemans, LBL, van Dam, AD, Loh, NY, Todorčević, M, Denton, N, Kentistou, KA, Joshi, PK, Christodoulides, C, Langenberg, C, Collas, P, Karpe, F, Pinnick, KE

Publikováno v: Kuo, F-C, Neville, M J, Sabaratnam, R, Wesolowska-Andersen, A, Phillips, D, Wittemans, L B L, van Dam, A D, Loh, N Y, Todorčević, M, Denton, N, Kentistou, K A, Joshi, P K, Christodoulides, C, Langenberg, C, Collas, P, Karpe, F & Pinnick, K E 2022, ' HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution ', Cell Reports, vol. 40, no. 4, 111136, pp. 111136 . https://doi.org/10.1016/j.celrep.2022.111136

Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyte d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476f16b1c4b5fd39ca5abe1d0b406856
https://pubmed.ncbi.nlm.nih.gov/36131101

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DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment

Autor: Bas Havekes, Carolina R. C. Pieterman, E B Conemans, Lodewijk A.A. Brosens, Menno R. Vriens, Cathy B. Moelans, P. H. Bisschop, Lutske Lodewijk, Madeleine L. Drent, I. H. M. Borel Rinkes, H. Th. Marc Timmers, Ad R. M. M. Hermus, A. N. A. van der Horst-Schrivers, Gerlof D. Valk, Folkert H.M. Morsink, Koen M.A. Dreijerink, G. J. A. Offerhaus, W. W. de Herder, Olaf M. Dekkers

Publikováno v: Conemans, E B, Lodewijk, L, Moelans, C B, Offerhaus, G J A, Pieterman, C R C, Morsink, F H, Dekkers, O M, De Herder, W W, Hermus, A R, Van Der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Brosens, L A A, Dreijerink, K M A, Rinkes, I H M B, Timmers, H T M, Valk, G D & Vriens, M R 2018, ' DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment ', European Journal of Endocrinology, vol. 179, no. 3, pp. 153-160 . https://doi.org/10.1530/EJE-18-0195
European journal of endocrinology / European Federation of Endocrine Societies, 179(3), 153-160. BioScientifica Ltd.
European Journal of Endocrinology, 179(3), 153-160. BIOSCIENTIFICA LTD
European Journal of Endocrinology, 179, 153-160
European Journal of Endocrinology, 179(3), 153-160
European Journal of Endocrinology, 179, 3, pp. 153-160
European Journal of Endocrinology, 179(3), 153-160. Bioscientifica Ltd
European Journal of Endocrinology, 179(3), 153-160. BioScientifica Ltd.
European Journal of Endocrinology, 179(3), 153. BioScientifica Ltd.
Conemans, E B, Lodewijk, L, Moelans, C B, Offerhaus, G J A, Pieterman, C R C, Morsink, F H, Dekkers, O M, de Herder, W W, Hermus, A R, van der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Brosens, L A A, Dreijerink, K M A, Borel Rinkes, I H M, Timmers, H T M, Valk, G D & Vriens, M R 2018, ' DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment ', European Journal of Endocrinology, vol. 179, no. 3, pp. 153-160 . https://doi.org/10.1530/EJE-18-0195

ObjectiveEpigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70073bddb0cfac1bc8627a5638d3af2a
https://doi.org/10.1530/eje-18-0195

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Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

Autor: Chris Sherlock, Ermelinda Porpiglia, Florentina Rus, Subba Reddy Palli, Rochele Yamamoto, Andreas Heyland, Alina Garbuzov, Neal S. Silverman, Marc Tatar, Thomas Flatt

Publikováno v: Flatt, T, Heyland, A, Rus, F, Porpiglia, E, Sherlock, C, Yamamoto, R, Garbuzov, A, Palli, S R, Tatar, M & Silverman, N 2008, ' Hormonal regulation of the humoral innate immune response in Drosophila melanogaster ', The Journal of Experimental Biology, vol. 211, no. Pt 16, pp. 2712-24 . https://doi.org/10.1242/jeb.014878

SUMMARYJuvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58043fe0f6d848020d4440e4097746df
http://doc.rero.ch/record/324338/files/2008_hth.pdf

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System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells

Autor: Michaël Baruchet, Aurélien Naldi, Cristina Casals-Casas, Béatrice Desvergne, Sylvain Pradervand, Leonore Wigger, Khanh B. Trang

Publikováno v: PLoS ONE
PloS one, vol. 14, no. 8, pp. e0220894
PLoS ONE, Vol 14, Iss 8, p e0220894 (2019)

Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous pathways of the intermediate metabolism. The purpose of the present study was to explore in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60a36afdcfd2a4dea2013c578bd6a5e
https://doi.org/10.1101/514976

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MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide. A Pooled Analysis of Four Clinical Trials

Autor: L. Burt Nabors, Thierry Gorlia, J. Straub, Olivier Chinot, Els Genbrugge, Monika E. Hegi, Mark R. Gilbert, Greg Jones, Wim Van Criekinge, Roger Stupp, Michael Weller

Publikováno v: Clin Cancer Res
Clinical cancer research, vol. 25, no. 6, pp. 1809-1816

Purpose: The methylation status of the O6-methylguanine DNA methyltransferase (MGMT) gene promoter is predictive for benefit from temozolomide in glioblastoma (GBM). A clinically optimized cutoff was sought allowing patient selection for therapy with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541f2a7bb7145dd80385e963d15f4466
https://www.zora.uzh.ch/id/eprint/161075/

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PROX1 is a transcriptional regulator of MMP14

Autor: Päivi M. Ojala, Kaisa Lehti, Ville Rantanen, Sampsa Hautaniemi, Kari Alitalo, Tatiana V. Petrova, Mark Bower, Ines Martinez-Corral, Endrit Elbasani, Markus Vähä-Koskela, Jianpin Cheng, Krista Tuohinto, Elisa Kaivanto, Taija Makinen, Caj Haglund, Silvia Gramolelli

Publikováno v: Scientific reports, vol. 8, no. 1, pp. 9531
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles. Here, we show that PROX1 suppresses t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec3c1fa79ad09a62bd075ca267da67d
https://serval.unil.ch/resource/serval:BIB_52BE6D877F2E.P001/REF.pdf

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