Výsledky vyhledávání - "Promod Mehndiratta"

An Industry Perspective on Forced Degradation Studies of Biopharmaceuticals: Survey Outcome and Recommendations

Autor: Wasfi Al-Azzam, Sambit R. Kar, Niclas Chiang Tan, Zhenyu Gu, Zoran Sosic, Crystal Cicchino, Alexandru C. Lazar, Paul Weisbach, Yite Robert Chou, Liqiang Lisa Zhou, Jennifer Halley, Santosh V. Thakkar, Smith John M, Magdalena Gauden, Elaine S.E. Stokes, Min Huang, Promod Mehndiratta, Vikas K. Sharma, Stephane Cornen

Publikováno v: Journal of Pharmaceutical Sciences. 109:6-21

The BioPhorum Development Group is an industry-wide consortium enabling networking and sharing of common practices for the development of biopharmaceuticals. Forced degradation studies (FDSs) are often used in biotherapeutic development to assess cri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d11b1229cff79fbcec3c77c6533a0e
https://doi.org/10.1016/j.xphs.2019.09.018

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Using bispecific antibodies in forced degradation studies to analyze the structure-function relationships of symmetrically and asymmetrically modified antibodies

Autor: Michael Capaldi, Promod Mehndiratta, Pedro Alfonso, Sarah Aubert, Frank Shi, Adam R. Evans, Geetha Goparaju, David C. Colter, Michael J. Lewis, Lian-Chao Li, Jingjie Mo, Ping Hu

Publikováno v: mAbs

Forced degradation experiments of monoclonal antibodies (mAbs) aid in the identification of critical quality attributes (CQAs) by studying the impact of post-translational modifications (PTMs), such as oxidation, deamidation, glycation, and isomeriza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f25696fcd675e421a6d0552e6e77fbe
https://pubmed.ncbi.nlm.nih.gov/31161859

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Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells

Autor: Alan G. Marshall, Wendy J. Walton, Gopalakrishnan Parthasarathy, Joan Hare, Silvia M. Pulido, Timothy M. Logan, Promod Mehndiratta, Mark R. Emmett

Publikováno v: Protein expression and purification. 33(2)

Structural studies of asparagine-linked glycoproteins are complicated by the oligosaccharide heterogeneity inherent to individual glycosylation sites. Herein, we report the cloning of a novel isoform of avian Thy-1 and the subsequent expression, puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cb1dd9c4608f11d32cb0aa567b6983
https://pubmed.ncbi.nlm.nih.gov/14711516

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