Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Prokopis C. Prokopiou"'
Autor:
Nina Engels-Domínguez, Elouise A. Koops, Stephanie Hsieh, Emma E. Wiklund, Aaron P. Schultz, Joost M. Riphagen, Prokopis C. Prokopiou, Bernard J. Hanseeuw, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological Alzheimer’s disease (AD) hallmark. This early
Externí odkaz:
https://doaj.org/article/1a2a23bb5bfe4f028d41e04abb34676d
Autor:
Jennifer Pahl, Prokopis C. Prokopiou, Elisenda Bueichekú, Aaron P. Schultz, Kathryn V. Papp, Michelle E. Farrell, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I.L. Jacobs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies reported that left frontoparietal network funct
Externí odkaz:
https://doaj.org/article/78a9e2d37a8948558daa424d3e911cd8
Autor:
Prokopis C. Prokopiou, Nina Engels-Domínguez, Kathryn V. Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/064e0e4a05864dea8910777843fb04ad
Autor:
Nina, Engels-Domínguez, Elouise A, Koops, Prokopis C, Prokopiou, Maxime, Van Egroo, Christoph, Schneider, Joost M, Riphagen, Tarun, Singhal, Heidi I L, Jacobs
Publikováno v:
Neuroscience and Biobehavioral Reviews, 144:104998. Elsevier Science
Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease (AD). Autopsy data indicates that the neuromodulatory subcortical systems' (NSS) nuclei are specifically vulnerable to initial tau pathology, indicating
Autor:
Prokopis C. Prokopiou, Nina Engels, Christoph Schneider, Aaron P. Schultz, Jorge Sepulcre, Joost M. Riphagen, Elouise A. Koops, Kathryn V. Papp, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I.L. Jacobs
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Joost M. Riphagen, Jasmeer P. Chhatwal, Alex Becker, Kenneth Kwong, Nina Engels, Wai‐Ying Wendy Yau, Prokopis C. Prokopiou, Christoph Schneider, Elouise A. Koops, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I.L. Jacobs
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Nina Engels, Stephanie Hsieh, Christoph Schneider, Prokopis C. Prokopiou, Aaron P. Schultz, Joost M. Riphagen, Elouise A. Koops, Bernard Hanseeuw, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I.L. Jacobs
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Prokopis C. Prokopiou, Nina Engels-Domínguez, Kathryn V. Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Nature Communications, 13(1):1571. Nature Publishing Group
Animal and human imaging research reported that the presence of cortical Alzheimer's Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with altered neuronal activity and circuitry failure, together facilitating clinic
Autor:
Heidi I.L. Jacobs, Alex Becker, Kenneth Kwong, Nina Engels, Prokopis C. Prokopiou, Kate V. Papp, Michael J Properzi, Olivia L. Hampton, Justin S. Sanchez, Dorene M. Rentz, Georges El Fakhri, Marc D. Normandin, David A. Bennett, Reisa A. Sperling, Keith A. Johnson
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Keith A. Johnson, Kenneth K. Kwong, Julie C. Price, Reisa A. Sperling, Federico d’Oleire Uquillas, Kathryn V. Papp, Georges El Fakhri, Michael J. Properzi, Justin S. Sanchez, Heidi I.L. Jacobs, Marc D. Normandin, John A. Becker, David A. Bennett, Nina Engels-Domínguez, Olivia L. Hampton, Prokopis C. Prokopiou, Dorene M. Rentz
Publikováno v:
Sci Transl Med
Science Translational Medicine, 13(612):eabj2511. American Association for the Advancement of Science
Science Translational Medicine, 13(612):eabj2511. American Association for the Advancement of Science
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU increases, TAU pathology emerges throughout the cortex. By conjointly using dedicated