Quality Control Mechanisms in Bacterial Translation

Autor: Ilya A. Osterman, Petr V. Sergiev, Anastasiia S. Zarechenskaia

Publikováno v: Acta Naturae

Ribosome stalling during translation significantly reduces cell viability, because cells have to spend resources on the synthesis of new ribosomes. Therefore, all bacteria have developed various mechanisms of ribosome rescue. Usually, the release of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2319de4e0a1acdbf23e33ccb2482c258
https://doi.org/10.32607/actanaturae.11401

RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus

Autor: Brice Felden, Noëlla Germain-Amiot, Régine Brielle, Camille Riffaud, Marie-Laure Pinel-Marie, Norbert Polacek

Publikováno v: Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2021, 6 (2), pp.209-220. ⟨10.1038/s41564-020-00819-2⟩
Nature Microbiology, 2021, 6 (2), pp.209-220. ⟨10.1038/s41564-020-00819-2⟩

International audience; Persister cells are a subpopulation of transiently antibiotic-tolerant bacteria associated with chronic infection and antibiotic treatment failure. Toxin-antitoxin systems have been linked to persister cell formation but the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1afcab41564a238d975688d2229caf2
https://doi.org/10.1038/s41564-020-00819-2

Ribosome rescue activity of an Arabidopsis thaliana ArfB homolog

Autor: Reiko Motohashi, Tatsuhiko Abo, Fumina Tsuchiya, Michiaki Nagao

Publikováno v: Genes & Genetic Systems. 95:119-131

A homolog of the bacterial ribosome rescue factor ArfB was identified in Arabidopsis thaliana. The factor, named AtArfB for Arabidopsis thaliana ArfB, showed ribosome rescue activity in both in vivo and in vitro assays based on the bacterial translat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63a6db00bd7105ba01d47ee573756066
https://doi.org/10.1266/ggs.20-00007

Ribosomal protein S1 plays a critical role in horizontal gene transfer by mediating the expression of foreign mRNAs

Autor: Luc Roberts, Hans-Joachim Wieden

The emergence of multi-antibiotic resistant bacteria is one of the largest threats to global heath. This rise is due to the genomic plasticity of bacteria, allowing rapid acquisition of antibiotic resistance through the uptake of foreign DNA (i.e. ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8850e6741f57cfd5d379552737abb024
https://doi.org/10.1101/2021.10.13.464283

Bacterial translation machinery for deliberate mistranslation of the genetic code

Autor: Manyun Chen, Ahmed H. Badran, Jonathan R Krieger, Sergey Melnikov, Yousong Ding, Ana Crnković, Kyle S. Hoffman, Dieter Söll, Oscar Vargas-Rodriguez, Eric Westhof

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 35, pp. 1-10, 2021.

Inaccurate expression of the genetic code, also known as mistranslation, is an emerging paradigm in microbial studies. Growing evidence suggests that many microbial pathogens can deliberately mistranslate their genetic code to help invade a host or e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff025b07effd48ce75ac64b8190a2a7
https://doi.org/10.1073/pnas.2110797118