Proinsulin C-peptide is a major source of HLA-DQ8 restricted hybrid insulin peptides recognized by human islet-infiltrating CD4 ⁺ T cells.

Autor: Bhattacharjee P; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Pakusch M; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Lacorcia M; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Tresoldi E; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Rubin AF; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia., Foster A; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., King L; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Chiu CY; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Kay TWH; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia., Karas JA; School of Chemistry, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia., Cameron FJ; Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, Melbourne, VIC 3052, Australia.; Murdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia., Mannering SI; Immunology and Diabetes Unit, St. Vincent's Institute of Medical Research, 9 Princes St, Fitzroy, VIC 3065, Australia.; Murdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia.; Department of Medicine, University of Melbourne, St. Vincent's Hospital, Fitzroy, VIC 3065, Australia.

Publikováno v: PNAS nexus [PNAS Nexus] 2024 Nov 01; Vol. 3 (11), pp. pgae491. Date of Electronic Publication: 2024 Nov 01 (Print Publication: 2024).

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Simultaneous attenuation of hyperglycemic memory-induced retinal, pulmonary, and glomerular dysfunctions by proinsulin C-peptide in diabetes

Autor: Hye-Yoon Jeon, Chan-Hee Moon, Eun-Bin Kim, Nilofar Danishmalik Sayyed, Ah-Jun Lee, Kwon-Soo Ha

Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-14 (2023)

Abstract Background Hyperglycemic memory (HGM) is a pivotal phenomenon in the development of diabetic complications. Although coincident diabetic complications are reported, research on their development and treatment is limited. Thus, we investigate

Externí odkaz: https://doaj.org/article/96d415a8f7574579bceb56acaf2bc3a8

Multiple Cell Signalling Pathways of Human Proinsulin C-Peptide in Vasculopathy Protection.

Autor: Souto, Selma B.¹ sbsouto.md@gmail.com, Campos, Joana R.² joanacampos92@gmail.com, Fangueiro, Joana F.² jffangueiro@gmail.com, Silva, Amélia M.^3,4 amsilva@utad.pt, Cicero, Nicola⁵ ncicero@unime.it, Lucarini, Massimo⁶ massimo.lucarini@crea.gov.it, Durazzo, Alessandra⁶ alessandra.durazzo@crea.gov.it, Santini, Antonello⁷ asantini@unina.it, Souto, Eliana B.^2,8 ebsouto@ff.uc.pt

Publikováno v: International Journal of Molecular Sciences. 1/15/2020, Vol. 21 Issue 2, p1-19. 19p. 1 Diagram, 1 Chart.