Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Progressive neurodegeneration"'
Autor:
Ye In Christopher Kwon, Wei Xie, Haizhou Zhu, Jiashu Xie, Keaton Shinn, Nicholas Juckel, Robert Vince, Swati S. More, Michael K. Lee
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1796 (2021)
Oxidative stress in Alzheimer’s disease (AD) is mediated, in part, by the loss of glutathione (GSH). Previous studies show that γ-glutamyl transpeptidase (GGT)-resistant GSH analog, Ψ-GSH, improves brain GSH levels, reduces oxidative stress marke
Externí odkaz:
https://doaj.org/article/2cdccac0ab3f4519869f07119d79c7b7
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 764 (2021)
The world continues a desperate search for therapies that could bring hope and relief to millions suffering from progressive neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD). With oxidative stress thought to be a core stre
Externí odkaz:
https://doaj.org/article/2dfc511cdd3b45a087e73fbb1dd3297d
Autor:
Martin H. Groschup, Christine Fast
Publikováno v:
Prions and Diseases ISBN: 9783031205644
Prions and Diseases ISBN: 9781461453376
Prions and Diseases ISBN: 9781461453376
Scrapie is a naturally occuring transmissible spongiform encephalopathy (TSE) in sheep, goat and mufflons almost world-wide and is known for about 250 years. It is characterized by the accumulation of an abnormal isoform (PrPSc) of host encoded prion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dec1ef84fced2282e7680416b5ed2c
https://doi.org/10.1007/978-3-031-20565-1_26
https://doi.org/10.1007/978-3-031-20565-1_26
Akademický článek
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Publikováno v:
Neurology. 97:1045-1048
Creutzfeld-Jakob Disease (CJD) is a rare disease but a common cause of rapidly progressive neurodegeneration. Although the "classic" presentation involves early dementia or behavioral changes, there are well-described atypical variants with less prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94095adcf501b599258d87a135476183
https://doi.org/10.1212/wnl.0000000000012613
https://doi.org/10.1212/wnl.0000000000012613
Autor:
Melinda Erdős
Publikováno v:
Orvosi Hetilap. 162:74-80
Összefoglaló. A Niemann–Pick-betegség autoszomális recesszíven öröklődő lizoszomális tárolási betegség, amelynek hátterében a savi szfingomielináz enzim hiánya vagy csökkent aktivitása (A-, A/B- és B-típus), illetve a Niemann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1493f87297c89172e96e1769ee4fd6b4
https://doi.org/10.1556/650.2021.31950
https://doi.org/10.1556/650.2021.31950
Autor:
Shawn C. Aylward, Nicolas J. Abreu, Jonathan Pindrik, W. Bruce Cherny, Emily de los Reyes, Matthew O’Neal
Publikováno v:
Expert Opinion on Orphan Drugs. 8:445-454
Introduction: Neuronal ceroid lipofuscinosis type 2 (CLN2) is a rare, lysosomal storage disease that causes progressive neurodegeneration in children. Cerliponase alfa enzyme replacement therapy is...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0387e35df40b11880b0e3f716505212f
https://doi.org/10.1080/21678707.2020.1856654
https://doi.org/10.1080/21678707.2020.1856654
Autor:
Zois Papadopoulos
Publikováno v:
Current Medical Science. 40:851-857
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness and visual impairment in individuals over the age of 50 years in western societies. More than 25 million people currently suffer from this illness in the world,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c721910e3b058bec6376f04a17d4c9ce
https://doi.org/10.1007/s11596-020-2253-6
https://doi.org/10.1007/s11596-020-2253-6
Publikováno v:
Practical Neurology. 21:243-245
Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage syndrome defined clinically by the triad of progressive neurodegeneration, juvenile cataracts and tendon xanthomas in adults. It is treatable, and a prompt diagnosis can impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d94cd352eefac26b61b4208dbead96
https://doi.org/10.1136/practneurol-2020-002895
https://doi.org/10.1136/practneurol-2020-002895
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 4, Pp 100915-(2021)
STAR Protocols, Vol 2, Iss 4, Pp 100915-(2021)
Summary Neuronal loss resulting from progressive neurodegeneration is a major pathological feature of Alzheimer’s disease (AD). Here, we present a protocol to detect neurodegeneration, neuronal apoptosis, and neuronal loss in 5XFAD mouse strain, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c198c1b826f1d977c4aafd97df24703
https://pubmed.ncbi.nlm.nih.gov/34755118
https://pubmed.ncbi.nlm.nih.gov/34755118