Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

Autor: Durfee, Cameron, Temiz, Nuri Alpay, Levin-Klein, Rena, Argyris, Prokopios P., Alsøe, Lene, Carracedo, Sergio, Alonso de la Vega, Alicia, Proehl, Joshua, Holzhauer, Anna M., Seeman, Zachary J., Liu, Xingyu, Lin, Yu-Hsiu T., Vogel, Rachel I., Sotillo, Rocio, Nilsen, Hilde, Harris, Reuben S.

Publikováno v: In Cell Reports Medicine 17 October 2023 4(10)

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Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases.

Autor: Durfee C; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA, 78229., Temiz NA; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota, USA, 55455.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA, 55455., Levin-Klein R; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA, 55455., Argyris PP; Division of Oral and Maxillofacial Pathology, College of Dentistry, Ohio State University, Columbus, Ohio, USA, 43210., Alsøe L; Department of Clinical Molecular Biology, University of Oslo, 0318, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, N-0424 Oslo, Norway., Carracedo S; Department of Clinical Molecular Biology, University of Oslo, 0318, Oslo, Norway., de la Vega AA; Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TRLC), German Center for Lung Research (DZL)., Proehl J; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA, 78229., Holzhauer AM; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA, 55455., Seeman ZJ; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA, 55455., Lin YT; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA, 78229., Vogel RI; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA, 55455.; Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA., Sotillo R; Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TRLC), German Center for Lung Research (DZL)., Nilsen H; Department of Clinical Molecular Biology, University of Oslo, 0318, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, N-0424 Oslo, Norway., Harris RS; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA, 78229.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas, USA, 78229.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 25. Date of Electronic Publication: 2023 Feb 25.