Advances in Prodrugs : Design and Therapeutic Applications. [elektronicky zdroj]

Autor: Trandafir Supuran, Claudiu

Externí odkaz: Kolekce e-knih KNAV (Registrovani uzivatele: plny text online 5 minut, dalsi pristup na vyzadani. Registered users: full text online 5 minutes, further access on request.)

Prodrugs Design: a New Era

Autor: Karaman, Rafik

The prodrug approach is a promising and well established strategy for the development of new entities that possess superior efficacy, selectivity and reduced toxicity. Hence an optimized therapeutic outcome can be accomplished using this approach. Pr

HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy-an in vitro exploration.

Autor: Tubertini, Matilde^1,2, Menilli, Luca³, Milani, Celeste⁴, Martini, Cecilia¹, Navacchia, Maria Luisa¹, Nugnes, Marta⁵, Bartolini, Manuela⁵, Naldi, Marina⁵, Tedesco, Daniele¹, Martella, Elisa¹, Guerrini, Andrea¹, Ferroni, Claudia¹, Moret, Francesca⁴ francesca.moret@unipd.it, Varchi, Greta¹ greta.varchi@isof.cnr.it, Rui-Rong Ye⁶, Thuru, Xavier⁷

Publikováno v: Frontiers in Chemistry. 2024, p01-18. 18p.

Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours.

Autor: Fu Q; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Zhang S; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China., Shen S; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Gu Z; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Chen J; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Song D; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China., Sun P; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Wang C; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Guo Z; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Xiao Y; Beijing National Laboratory of Molecular Sciences, Institute of Theoretical and Computational Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Gao YQ; Beijing National Laboratory of Molecular Sciences, Institute of Theoretical and Computational Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China., Guo Z; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China. zguo@nju.edu.cn., Liu Z; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. zbliu@pku.edu.cn.; Peking University-Tsinghua University Center for Life Sciences, Peking University, Beijing, China. zbliu@pku.edu.cn.; Changping Laboratory, Beijing, China. zbliu@pku.edu.cn.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), National Medical Products Administration Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China. zbliu@pku.edu.cn.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Nov; Vol. 8 (11), pp. 1425-1435. Date of Electronic Publication: 2024 Jul 18.

Hypoxia-Activated Theragnostic Prodrugs (HATPs): Current State and Future Perspectives.

Autor: Bhuniya, Sankarprasad¹ (AUTHOR) spbhuniya@jisiasr.org, Vrettos, Eirinaios I.² (AUTHOR) eirinaios.vrettos@stjude.org

Publikováno v: Pharmaceutics. Apr2024, Vol. 16 Issue 4, p557. 17p.