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Akademický článek

Extraction of the Anticancer and Antimicrobial Agent, Prodigiosin, from Vibrio gazogenes PB1 and Its Identification by 1D and 2D NMR

Autor: Dhanya Vijay, Nassra S. Alshamsi, Ziad Moussa, M. Kalim Akhtar

Publikováno v: Molecules, Vol 27, Iss 18, p 6030 (2022)

Prodigiosin is a secondary metabolite produced in several species of bacteria. It exhibits antimicrobial and anticancer properties. Methods for the extraction and identification of prodigiosin and their related derivatives from bacterial cultures typ

Externí odkaz: https://doaj.org/article/2abcbad133c94383a00cf92700ead8c8

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Akademický článek

Characterization of Prodiginine Pathway in Marine Sponge-Associated Pseudoalteromonas sp. PPB1 in Hilo, Hawai‘i

Autor: Francis E. Sakai-Kawada, Courtney G. Ip, Kehau A. Hagiwara, Hoang-Yen X. Nguyen, Christopher-James A. V. Yakym, Martin Helmkampf, Ellie E. Armstrong, Jonathan D. Awaya

Publikováno v: Frontiers in Sustainable Food Systems, Vol 4 (2020)

Interest in bioactive pigments stems from their ecological role in adaptation, as well as their applications in various consumer products. The production of these bioactive pigments can be from a variety of biological sources, including simple microo

Externí odkaz: https://doaj.org/article/913eb3b888c548259a7906ab670fd720

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Akademický článek

Discovery of New Secondary Metabolites from Marine Bacteria Hahella Based on an Omics Strategy

Autor: Shufen He, Peishan Li, Jingxuan Wang, Yanzhu Zhang, Hongmei Lu, Liufei Shi, Tao Huang, Weiyan Zhang, Lijian Ding, Shan He, Liwei Liu

Publikováno v: Marine Drugs, Vol 20, Iss 4, p 269 (2022)

Hahella is one characteristic genus under the Hahellaceae family and shows a good potential for synthesizing new natural products. In this study, we examined the distribution of the secondary metabolite biosynthetic gene cluster (SMBGC) under Hahella

Externí odkaz: https://doaj.org/article/bbeb88f4e7514baf8fdab7c80ef0ba21

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A two-step resin based approach to reveal survivin-selective fluorescent probes

Autor: Jared Sivinski, Niloufar Mollasalehi, Manfred Auer, Paula C. Jimenez, James J. La Clair, Andrew J. Ambrose, Steven Shave, Nhan T. Pham, A. Arockia Jeyaprakash, Letícia V. Costa-Lotufo, Larissa A. Guimarães, Eli Chapman, Maria Alba Abad

Publikováno v: RSC Chemical Biology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Ambrose, A J, Pham, N T, Sivinski, J, Guimarães, L, Mollasalehi, N, Jimenez, P, Abad, M A, Jeyaprakash, A A, Shave, S, Costa-Lotufo, L V, La Clair, J J, Auer, M & Chapman, E 2020, ' A two-step resin based approach to reveal survivin-selective fluorescent probes ', RSC Chemical Biology . https://doi.org/10.1039/D0CB00122H

The identification of modulators for proteins without assayable biochemical activity remains a challenge in chemical biology. The presented approach adapts a high-throughput fluorescence binding assay and functional chromatography, two protein-resin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46de572cb905210281edacbf4c384c4
https://doi.org/10.1039/d0cb00122h

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Violacein and Prodiginines from Marine Bacteria

Autor: Keiichi Enomoto

Publikováno v: Encyclopedia of Marine Biotechnology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0f2fdfc50678e37bf4ba8c5ed40757c
https://doi.org/10.1002/9781119143802.ch71

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Purification and Kinetic Characterization of the Essential Condensation Enzymes Involved in Prodiginine and Tambjamine Biosynthesis

Autor: Victor Snieckus, Katherine J. Picott, Julie A. Deichert, Avena C. Ross, Ella Marie deKemp

Publikováno v: ChemBioChem. 21:1036-1042

Prodiginines and tambjamines are related families of bioactive alkaloid natural products with pharmaceutical potential. Both compound families result from a convergent biosynthetic pathway ending in the condensation of a conserved bipyrrole core with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21907e11c8bb6792020df8864cb99754
https://doi.org/10.1002/cbic.201900503

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Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in Streptomyces coelicolor M145

Autor: Erin E. Carlson, Andrew R. Johnson, Regan J. Thomson, Marvin M. Vega, Andrew P. Marshall

Publikováno v: J Nat Prod

Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (2) as the natural product produced by Streptomyces coelicolor. Natural product 2 was initially assigned as butylcycloheptylprodigiosin (3), and only relatively rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e35744be92cd115e24a54df819599c
https://doi.org/10.1021/acs.jnatprod.9b00828

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A colourimetric high-throughput screening system for directed evolution of prodigiosin ligase PigC

Autor: Stefanie Brands, Andreas Sebastian Klein, Anna Joëlle Ruff, Hannah U. C. Brass, Jörg Pietruszka, Ulrich Schwaneberg

Publikováno v: Chemical communications 56(61), 8631-8634 (2020). doi:10.1039/D0CC02181D

A colourimetric high-throughput screening system was established for directed evolution of prodigiosin ligase PigC. The two-step system consists of a colony prescreening test and a subsequent photometric 96-well plate assay. Screening PigC epPCR libr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012c6bc42ca8f04f4aeeaaefe2adfe51
https://doi.org/10.1039/d0cc02181d

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