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Akademický článek

Cognitive Decline With Low-Dose Procyclidine and Improvement Following Removal of Anticholinergic Burden.

Autor: Aboelenien, Shaimaa¹, Cherian, Vinu², Philip, Joel²

Publikováno v: BJPsych Open. 2024 Supplement 1, Vol. 10, pS274-S274. 1p.

Akademický článek

Do macroprudential policy instruments reduce the procyclical impact of capital ratio on bank lending? Cross-country evidence.

Autor: Olszak, Małgorzata¹ molszak@wz.uw.edu.pl, Roszkowska, Sylwia², Kowalska, Iwona³

Publikováno v: Baltic Journal of Economics. Jun2019, Vol. 19 Issue 1, p1-38. 38p.

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Akademický článek

PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes

Autor: Yan-Zi Wen, Hao-Tian Tang, Xiao-Li Cai, Na Wu, Jia-Zhen Xu, Bi-Xiu Su, Geoff Hide, Zhao-Rong Lun, De-Hua Lai

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

IntroductionTrypanosoma brucei, T. evansi and T. equiperdum are members of the subgenus Trypanozoon and are highly similar morphologically and genetically. The main differences between these three species are their differentiation patterns in the hos

Externí odkaz: https://doaj.org/article/521ae0c749b8493093200d40ec028945

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Akademický článek

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Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole

Autor: Kathryn Crouch, Fiona Achcar, Federica Giordani, Annette MacLeod, Isabel M. Vincent, Pieter C. Steketee, Michael P. Barrett, Liam J. Morrison, Nicholas J. Dickens

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939

Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c029f51fa7a39962a0477e623a2d5bbc
http://europepmc.org/articles/PMC8648117

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Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

Autor: Sebastian Knüsel, Anant K. Menon, Isabel Roditi, Michael A. J. Ferguson, Peter Bütikofer, Robert Häner, Aurelio Jenni, Mattias Benninger, Rupa Nagar

Publikováno v: Jenni, Aurelio; Knüsel, Sebastian; Nagar, Rupa; Benninger, Mattias; Häner, Robert; Ferguson, Michael A J; Roditi, Isabel; Menon, Anant K; Bütikofer, Peter (2021). Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei. The journal of biological chemistry, 297(2), p. 100977. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100977
The Journal of Biological Chemistry

The biosynthesis of glycosylphosphatidylinositol (GPI) membrane protein anchors is initiated in the endoplasmic reticulum by transfer of GlcNAc from the sugar nucleotide UDP-GlcNAc to phosphatidylinositol. The reaction is catalyzed by GPI GlcNAc tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0610e0266f5daba93358900fde465f3d
https://boris.unibe.ch/158326/1/1-s2.0-S0021925821007791-main.pdf

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Identification of clinically approved small molecules that inhibit growth and affect transcript levels of developmentally regulated genes in the African trypanosome

Autor: Eleanor Mary Naudzius, Savanah Jessica Diaz, Madison Elle Walsh, Mikhail Martchenko, Danae Schulz, Theodore William Wismar

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007790 (2020)
PLoS Neglected Tropical Diseases

Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ce5ab3ca8d6f3ae93d631e8b8aa77f
https://doaj.org/article/edaab3f5b4a04043b67ecfce82fb7c71

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The Trypanosoma brucei TbHrg protein is a heme transporter involved in the regulation of stage-specific morphological transitions

Autor: Julius Lukeš, Benoit Vanhollebeke, Eva Horáková, Jan Van Den Abbeele, Piya Changmai, Roman Sobotka, Marie Vancová

Publikováno v: Journal of Biological Chemistry. 292:6998-7010

The human parasite Trypanosoma brucei does not synthesize heme de novo and instead relies entirely on heme supplied by its vertebrate host or its insect vector, the tsetse fly. In the host bloodstream T. brucei scavenges heme via haptoglobin-hemoglob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5501b40d1a64890adb05141b6f97afdf
https://doi.org/10.1074/jbc.m116.762997

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