Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.

Autor: Wagemann O; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Liu H; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Wang G; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Shi X; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Bittner T; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Scelsi MA; F. Hoffmann-La Roche Products Ltd, Welwyn Garden City, United Kingdom., Farlow MR; Department of Neurology, Indiana University School of Medicine, Indianapolis., Clifford DB; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Supnet-Bell C; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Santacruz AM; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Aschenbrenner AJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Hassenstab JJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Benzinger TLS; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Gordon BA; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Coalier KA; IQVIA, Durham, North Carolina., Cruchaga C; Department of Psychiatry, Washington University in St Louis, St Louis, Missouri., Ibanez L; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Psychiatry, Washington University in St Louis, St Louis, Missouri., Perrin RJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri., Xiong C; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Li Y; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Lah JJ; Department of Neurology, School of Medicine Emory University, Atlanta, Georgia., Berman SB; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham., van Dyck CH; Alzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut., Galasko D; Department of Neurology, University of California, San Diego., Gauthier S; Department of Neurology & Psychiatry, McGill University, Montréal, Québec, Canada., Hsiung GR; Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Brooks WS; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia., Pariente J; Department of Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Mummery CJ; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom., Day GS; Department of Neurology, Mayo Clinic Florida, Jacksonville., Ringman JM; Department of Neurology, University of Southern California, Los Angeles., Mendez PC; Fundación Para la Lucha Contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina., St George-Hyslop P; Department of Neurology, Columbia University, New York, New York., Fox NC; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom., Suzuki K; National Defense Medical College, Saitama, Japan., Okhravi HR; Department of Geriatrics, Eastern Virginia Medical School, Norfolk., Chhatwal J; Department of Neurology, Massachusetts General and Brigham & Women's Hospitals, Harvard Medical School, Boston., Levin J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Jucker M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Sims JR; Eli Lilly and Company, Indianapolis, Indiana., Holdridge KC; Eli Lilly and Company, Indianapolis, Indiana., Proctor NK; Eli Lilly and Company, Indianapolis, Indiana., Yaari R; Eli Lilly and Company, Indianapolis, Indiana., Andersen SW; Eli Lilly and Company, Indianapolis, Indiana., Mancini M; Eli Lilly and Company, Indianapolis, Indiana., Llibre-Guerra J; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., McDade E; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.

Publikováno v: JAMA neurology [JAMA Neurol] 2024 Jun 01; Vol. 81 (6), pp. 582-593.

Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.

Autor: Thijssen EH; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, Netherlands., La Joie R; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Strom A; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Fonseca C; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Iaccarino L; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Wolf A; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Spina S; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Allen IE; Epidemiology and Biostatistics, University of California, San Francisco, CA, USA., Cobigo Y; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Heuer H; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., VandeVrede L; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Proctor NK; Eli Lilly and Company, Indianapolis, IN, USA., Lago AL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Baker S; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Sivasankaran R; Novartis, Cambridge, MA, USA., Kieloch A; Novartis, Cambridge, MA, USA., Kinhikar A; Novartis, Cambridge, MA, USA., Yu L; Novartis, Cambridge, MA, USA., Valentin MA; Novartis, Cambridge, MA, USA., Jeromin A; Quanterix, Billerica, MA, USA., Zetterberg H; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute at UCL, University College London, London, UK., Hansson O; Clinical Memory Research Unit, Lund University, Lund, Sweden., Mattsson-Carlgren N; Clinical Memory Research Unit, Lund University, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden., Graham D; Biogen, Cambridge, MA, USA., Blennow K; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Kramer JH; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Grinberg LT; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, CA, USA., Seeley WW; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, CA, USA., Rosen H; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Miller BL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, Netherlands., Rabinovici GD; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA., Rojas JC; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Dage JL; Eli Lilly and Company, Indianapolis, IN, USA., Boxer AL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address: adam.boxer@ucsf.edu.

Publikováno v: The Lancet. Neurology [Lancet Neurol] 2021 Sep; Vol. 20 (9), pp. 739-752.

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study.

Autor: Hendrix JA; LuMind IDSC, 20 Mall Road, Suite 200, Burlington, MA 01803-4126, USA., Airey DC; Eli Lilly and Company, 893 Delaware St. Indianapolis, IN 46225, USA., Britton A; LuMind IDSC, 20 Mall Road, Suite 200, Burlington, MA 01803-4126, USA., Burke AD; St. Joseph's Hospital and Medical Center, Department of Neurology, Barrow Neurological Institute, 350 W. Thomas Rd., Phoenix, AZ 85013, USA., Capone GT; Down Syndrome Clinic & Research Center, Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205, USA., Chavez R; Department of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA., Chen J; Rush University Medical Center, Division of Developmental Behavioral Pediatrics, Department of Pediatrics, 1653 W. Congress Pkwy, Chicago, IL 60612, USA., Chicoine B; Adult Down Syndrome Center, Advocate Medical Group, 1610 Luther Lane, Park Ridge, IL 60068, USA., Costa ACS; Division of Neurology and Epilepsy, Department of Pediatrics, Department of Psychiatry, Case Western Reserve University School of Medicine, 10524 Euclid Ave, Cleveland, OH 44106, USA., Dage JL; Eli Lilly and Company, 893 Delaware St. Indianapolis, IN 46225, USA., Doran E; Department of Pediatrics, The University of California, Irvine, 333 The City Blvd. West, Suite 800, Orange, CA 92868-4482, USA., Esbensen A; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.; Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA., Evans CL; Department of Psychiatry, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA., Faber KM; National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University School of Medicine, 410 W 10th St, Indianapolis, IN 46202, USA., Foroud TM; National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University School of Medicine, 410 W 10th St, Indianapolis, IN 46202, USA., Hart S; Duke University Medical Center, Department of Pediatrics, 2301 Erwin Road, Durham, NC 27705, USA., Haugen K; Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA., Head E; Department of Pathology and Laboratory Medicine, The University of California, Irvine, School of Medicine, 1111 Gillepsie Neuroscience Research Facility, Irvine, CA 92697, USA., Hendrix S; Pentara Corporation, 2261 East 3300 South, Suite 200, Millcreek, UT 84109, USA., Hillerstrom H; LuMind IDSC, 20 Mall Road, Suite 200, Burlington, MA 01803-4126, USA., Kishnani PS; Duke University Medical Center, Department of Pediatrics, 2301 Erwin Road, Durham, NC 27705, USA., Krell K; Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA., Ledesma DL; Department of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA., Lai F; Department of Neurology, Massachusetts General Hospital, McLean Hospital, and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA., Lott I; Department of Pediatrics, The University of California, Irvine, 333 The City Blvd. West, Suite 800, Orange, CA 92868-4482, USA., Ochoa-Lubinoff C; Rush University Medical Center, Division of Developmental Behavioral Pediatrics, Department of Pediatrics, 1653 W. Congress Pkwy, Chicago, IL 60612, USA., Mason J; Department of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA., Nicodemus-Johnson J; Pentara Corporation, 2261 East 3300 South, Suite 200, Millcreek, UT 84109, USA., Proctor NK; Eli Lilly and Company, 893 Delaware St. Indianapolis, IN 46225, USA., Pulsifer MB; Department of Psychiatry, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA., Revta C; Department of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA., Rosas HD; Department of Neurology, Massachusetts General Hospital, McLean Hospital, and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA., Rosser TC; Department of Human Genetics, Emory University, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA., Santoro S; Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.; Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Schafer K; Department of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA., Scheidemantel T; University Hospitals Cleveland Medical Center, Department of Psychiatry, Case Western Reserve University School of Medicine, 10524 Euclid Ave, Cleveland, OH 44106, USA., Schmitt F; Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St., Lexington, KY 40536, USA., Skotko BG; Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.; Department of Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Stasko MR; University Hospitals Cleveland Medical Center, Department of Psychiatry, Case Western Reserve University School of Medicine, 10524 Euclid Ave, Cleveland, OH 44106, USA., Talboy A; Department of Human Genetics, Emory University School of Medicine, 1365 Clifton Road, NE, Building A, Suite 2200, Atlanta, GA 30322, USA., Torres A; Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA., Wilmes K; National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University School of Medicine, 410 W 10th St, Indianapolis, IN 46202, USA., Woodward J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.; Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA., Zimmer JA; Eli Lilly and Company, 893 Delaware St. Indianapolis, IN 46225, USA., Feldman HH; Department of Neurosciences, Alzheimer's Disease Cooperative Study, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0949, USA., Mobley W; Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0662, USA.

Publikováno v: Journal of clinical medicine [J Clin Med] 2021 Apr 28; Vol. 10 (9). Date of Electronic Publication: 2021 Apr 28.

Individualized prognosis of cognitive decline and dementia in mild cognitive impairment based on plasma biomarker combinations.

Autor: Cullen NC; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden., Leuzy A; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden., Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.; Memory Clinic, Skåne University Hospital, Lund, Sweden., Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden., Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.; Memory Clinic, Skåne University Hospital, Lund, Sweden., Pesini P; Araclon Biotech, Zaragoza, Spain., Sarasa L; Araclon Biotech, Zaragoza, Spain., Allué JA; Araclon Biotech, Zaragoza, Spain., Proctor NK; Eli Lilly and Company, Indianapolis, IN, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute, University College London, London, UK., Dage JL; Eli Lilly and Company, Indianapolis, IN, USA., Blennow K; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden. niklas.mattsson-carlgren@med.lu.se.; Department of Neurology, Skåne University Hospital, Lund, Sweden. niklas.mattsson-carlgren@med.lu.se.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden. niklas.mattsson-carlgren@med.lu.se., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden. oskar.hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Lund, Sweden. oskar.hansson@med.lu.se.

Publikováno v: Nature aging [Nat Aging] 2021 Jan; Vol. 1 (1), pp. 114-123. Date of Electronic Publication: 2020 Nov 30.

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease.

Autor: Janelidze S; Clinical Memory Research Unit, Lund University, Sölvegatan 18, Lund, Sweden. shorena.janelidze@med.lu.se., Stomrud E; Clinical Memory Research Unit, Lund University, Sölvegatan 18, Lund, Sweden., Smith R; Clinical Memory Research Unit, Lund University, Sölvegatan 18, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Entrégatan 7, 222 42, Lund, Sweden., Palmqvist S; Clinical Memory Research Unit, Lund University, Sölvegatan 18, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Entrégatan 7, 222 42, Lund, Sweden., Mattsson N; Clinical Memory Research Unit, Lund University, Sölvegatan 18, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Entrégatan 7, 222 42, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Klinikgatan 32, 221 84, Lund, Sweden., Airey DC; Eli Lilly and Company, Indianapolis, IN, 46285, USA., Proctor NK; Eli Lilly and Company, Indianapolis, IN, 46285, USA., Chai X; Eli Lilly and Company, Indianapolis, IN, 46285, USA., Shcherbinin S; Eli Lilly and Company, Indianapolis, IN, 46285, USA., Sims JR; Eli Lilly and Company, Indianapolis, IN, 46285, USA., Triana-Baltzer G; Neuroscience Biomarkers, Janssen Research & Development, 3210 Merryfield Row, San Diego, CA, CA 92121, USA., Theunis C; Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium., Slemmon R; Neuroscience Biomarkers, Janssen Research & Development, 3210 Merryfield Row, San Diego, CA, CA 92121, USA., Mercken M; Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340, Beerse, Belgium., Kolb H; Neuroscience Biomarkers, Janssen Research & Development, 3210 Merryfield Row, San Diego, CA, CA 92121, USA. HKolb1@ITS.jnj.com., Dage JL; Eli Lilly and Company, Indianapolis, IN, 46285, USA. Jeffrey.Dage@Lilly.com., Hansson O; Clinical Memory Research Unit, Lund University, Sölvegatan 18, Lund, Sweden. Oskar.Hansson@med.lu.se.; Memory Clinic, Skåne University Hospital, Simrisbanvägen 14, 205 02, Malmö, Sweden. Oskar.Hansson@med.lu.se.

Publikováno v: Nature communications [Nat Commun] 2020 Apr 03; Vol. 11 (1), pp. 1683. Date of Electronic Publication: 2020 Apr 03.