Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside

Autor: D.S. Leitão, A.R. Andrade, N.C.L. Medeiros, M.F.C. Martins, L.O. Ferreira, V.C. Santos, A.O. Hamoy, L.A.L. Barbas, N.A. Muto, V. Jóia de Mello, D.C.F. Lopes, M. Hamoy

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 55 (2022)

Seizures are a disorder caused by structural brain lesions, life-threatening metabolic derangements, or drug toxicity. The present study describes the behavior related to proconvulsant activity induced by thiocolchicoside (TCC) in rats and investigat

Externí odkaz: https://doaj.org/article/b25989a81e7146a39f2f5a795ac3f83f

Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside

Autor: D.S. Leitão, A.R. Andrade, N.C.L. Medeiros, M.F.C. Martins, L.O. Ferreira, V.C. Santos, A.O. Hamoy, L.A.L. Barbas, N.A. Muto, V. Jóia de Mello, D.C.F. Lopes, M. Hamoy

Publikováno v: Brazilian Journal of Medical and Biological Research, Volume: 55, Article number: e11771, Published: 28 FEB 2022
Brazilian Journal of Medical and Biological Research v.55 2022
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

Seizures are a disorder caused by structural brain lesions, life-threatening metabolic derangements, or drug toxicity. The present study describes the behavior related to proconvulsant activity induced by thiocolchicoside (TCC) in rats and investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac56294633d4bb451fa1908528aed425
https://pubmed.ncbi.nlm.nih.gov/35239777

Neuroservice proconvulsive (NS-PC) set: A new platform of electrophysiology-based assays to determine the proconvulsive potential of lead compounds

Autor: Fabien Maddalena, Esther Steidl, Bruno Buisson, Dominique Debanne, Melanie Gleyzes

Publikováno v: Journal of Pharmacological and Toxicological Methods
Journal of Pharmacological and Toxicological Methods, Elsevier, 2019, ⟨10.1016/j.vascn.2019.106587⟩
Journal of Pharmacological and Toxicological Methods, 2019, ⟨10.1016/j.vascn.2019.106587⟩

Introduction Failures in drug development often result from the emergence of unexpected adverse drug reactions. It is clear that adverse drug reactions, including seizure liability, should be assessed earlier. The goal of the present work was to deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69002d82da232f0f5fb8391a92b181a
https://hal-amu.archives-ouvertes.fr/hal-02363593

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