Neuroservice proconvulsive (NS-PC) set: A new platform of electrophysiology-based assays to determine the proconvulsive potential of lead compounds

Autor: Steidl, Esther, Gleyzes, Melanie, Maddalena, Fabien, Debanne, Dominique, Buisson, Bruno

Publikováno v: In Journal of Pharmacological and Toxicological Methods September-October 2019 99

The opposite effect of convulsant drugs on neuronal and endothelial nitric oxide synthase – A possible explanation for the dual proconvulsive/anticonvulsive action of nitric oxide

Autor: Lourdes A. Vega Rasgado, Eva Ramón-Gallegos, Lorena Rodríguez-Páez, Verónica Alcántara-Farfán

Publikováno v: Acta Pharmaceutica
Volume 73
Issue 1

Nitric oxide (NO) participates in processes such as endothelium-dependent vasodilation and neurotransmission/neuromodulation. The role of NO in epilepsy is controversial, attributing it to anticonvulsant but also proconvulsant properties. Clarificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9fcd1e8c35d165b6fc8404c26adf07
https://doi.org/10.2478/acph-2023-0004

Neuroservice proconvulsive (NS-PC) set: A new platform of electrophysiology-based assays to determine the proconvulsive potential of lead compounds

Autor: Fabien Maddalena, Esther Steidl, Bruno Buisson, Dominique Debanne, Melanie Gleyzes

Publikováno v: Journal of Pharmacological and Toxicological Methods
Journal of Pharmacological and Toxicological Methods, Elsevier, 2019, ⟨10.1016/j.vascn.2019.106587⟩
Journal of Pharmacological and Toxicological Methods, 2019, ⟨10.1016/j.vascn.2019.106587⟩

Introduction Failures in drug development often result from the emergence of unexpected adverse drug reactions. It is clear that adverse drug reactions, including seizure liability, should be assessed earlier. The goal of the present work was to deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69002d82da232f0f5fb8391a92b181a
https://hal-amu.archives-ouvertes.fr/hal-02363593

Proconvulsive effect of hydrochlorothiazide in an in vitro rat seizure model

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 17, Iss 11, Pp 860-866 (2014)

Objective(s):Protective effects of diuretics, particularly of hydrochlorothiazide (HCT), for the development of seizure attacksepilepsy have been described in vivo. However, itsthe mechanism of action of HCT is unknownneeds to be elucidated. Material

Externí odkaz: https://doaj.org/article/ba31daefb26446ae9581bb9be1959de0

SEARCH FOR A MORPHOLOGICAL SUBSTRATE FOR THE PROCONVULSIVE ACTION OF BUSULFAN

Autor: Elena Sukhorukova, Galina Yukina, Alexey Polushin, Yaroslav Skiba, Irina Belozertseva

Publikováno v: NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::979995cfb1e5beb941775c43e9655004
https://doi.org/10.29003/m2949.sudak.ns2022-18/334-335