Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex.

Autor: Bigge CF; Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105., Malone TC, Hays SJ, Johnson G, Novak PM, Lescosky LJ, Retz DM, Ortwine DF, Probert AW Jr, Coughenour LL, et. al.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1993 Jul 09; Vol. 36 (14), pp. 1977-95.

Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.

Autor: Bigge CF; Department of Chemistry and Neuroscience Pharmacology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105., Johnson G, Ortwine DF, Drummond JT, Retz DM, Brahce LJ, Coughenour LL, Marcoux FW, Probert AW Jr

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1992 Apr 17; Vol. 35 (8), pp. 1371-84.

Hypoxic neuronal injury in tissue culture is associated with delayed calcium accumulation.

Autor: Marcoux FW; Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Mich 48105., Probert AW Jr, Weber ML

Publikováno v: Stroke [Stroke] 1990 Nov; Vol. 21 (11 Suppl), pp. III71-4.

Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.

Autor: Bigge CF; Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105., Drummond JT, Johnson G, Malone T, Probert AW Jr, Marcoux FW, Coughenour LL, Brahce LJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1989 Jul; Vol. 32 (7), pp. 1580-90.