Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Pro-Drugs"'
Publikováno v:
Nanotechnology Reviews, Vol 13, Iss 1, Pp 1-49 (2024)
The COVID-19 pandemic strongly stimulated research on anti-SARS-CoV-2 virus treatments. The present study reviews a nanotechnology approach to this task, i.e., in other terms, a nanomedicine approach. Nanotechnology aims to create nanostructures or n
Externí odkaz:
https://doaj.org/article/2aa935171b0145c8a2764daf497c0b33
Publikováno v:
Drug Delivery, Vol 26, Iss 1, Pp 328-342 (2019)
Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus
Externí odkaz:
https://doaj.org/article/ac03b46667cd4f56972307f50b74f990
Akademický článek
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Autor:
Eoin Moynihan, Silvia Panseri, Giada Bassi, Arianna Rossi, Elisabetta Campodoni, Eithne Dempsey, Monica Montesi, Trinidad Velasco-Torrijos, Diego Montagner
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6028
Despite the enormous importance of cisplatin as a chemotherapeutic agent, its application is impacted by dose-limiting side effects and lack of selectivity for cancer cells. Researchers can overcome these issues by taking advantage of the pro-drug na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a97ec84d369da2205f1688875b50a0
https://zenodo.org/record/7781704
https://zenodo.org/record/7781704
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 344 (2020)
In order to efficiently combat neuroinflammation, it is essential to deliver the anti-inflammatory drugs to their target sites in the brain. Pro-drugs utilizing the L-type amino acid transporter 1 (LAT1) can be transported across the blood-brain barr
Externí odkaz:
https://doaj.org/article/f242e94c50e34871bd6ab47eb65f2586
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 323 (2020)
Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early
Externí odkaz:
https://doaj.org/article/84c8db33f6834f3288df4319a311443a
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in cr
Externí odkaz:
https://doaj.org/article/991d25141cba4eab86074783aa858d50
Akademický článek
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Akademický článek
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Autor:
Jean-Pierre Sommadossi, Steven S. Good, Adel Moussa, Justin G. Julander, Abbie Weight, Kai Lin
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0009937 (2022)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Yellow fever virus (YFV) is a zoonotic pathogen re-emerging in parts of the world, causing a viral hemorrhagic fever associated with high mortality rates. While an effective vaccine is available, having an effective antiviral against YFV is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b66f36fe30e882a326309e5a3a2193
https://doaj.org/article/8ed7f16b143b4c3195cab3f38bd25777
https://doaj.org/article/8ed7f16b143b4c3195cab3f38bd25777