Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Priyojit Das"'
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTChromatin regions that interact with the nuclear lamina are often heterochromatic, repressed in gene expression, and in the spatial B compartment. However, exceptions to this trend allow us to examine the relative impact of lamin association
Externí odkaz:
https://doaj.org/article/6d358b71f6d745559b64ec3951062b26
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2240-2250 (2024)
The 3D conformations of chromosomes can encode biological significance, and the implications of such structures have been increasingly appreciated recently. Certain chromosome structural features, such as A/B compartmentalization, are frequently extr
Externí odkaz:
https://doaj.org/article/0c0697b30ae44fc49d46b7a871f4414d
Autor:
Jacob T. Sanders, Rosela Golloshi, Priyojit Das, Yang Xu, Peyton H. Terry, Darrian G. Nash, Job Dekker, Rachel Patton McCord
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Layers of genome organization are becoming increasingly better characterized, but less is known about how these structures respond to perturbation or shape changes. Low-salt swelling of isolated chromatin fibers or nuclei has been used for d
Externí odkaz:
https://doaj.org/article/b467fe581014489d9d041d7c09c690ef
Publikováno v:
eLife, Vol 11 (2022)
The expression of a mutant Lamin A, progerin, in Hutchinson-Gilford Progeria Syndrome leads to alterations in genome architecture, nuclear morphology, epigenetic states, and altered phenotypes in all cells of the mesenchymal lineage. Here, we report
Externí odkaz:
https://doaj.org/article/93d35281d3b64f40b9d5391532696c92
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010392 (2022)
Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well unders
Externí odkaz:
https://doaj.org/article/f7febf0778b84278bf23c6e92d5e573d
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-28 (2020)
Abstract Background The nonrandom radial organization of eukaryotic chromosome territories (CTs) inside the nucleus plays an important role in nuclear functional compartmentalization. Increasingly, chromosome conformation capture (Hi-C) based approac
Externí odkaz:
https://doaj.org/article/78521c13a7334b769f09b403fe8cc4ff
Autor:
Rebeca San Martin, Priyojit Das, Tianchun Xue, Morgan Rose Brown, Renata Dos Reis Marques, Michael Essington, Adrian Gonzalez, Rachel Patton McCord
Publikováno v:
bioRxiv
Bone metastasis remains one of the biggest challenges in the treatment of prostate cancer, and other solid tumors such as breast, lung, and colon. Modeling a complex microenvironment in-vitro, such as the bone niche, requires interrogation of cell-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c021010df0fdd5879ec6495be5494c9
https://europepmc.org/articles/PMC10055203/
https://europepmc.org/articles/PMC10055203/
Autor:
Rosela Golloshi, Christopher Playter, Trevor F Freeman, Priyojit Das, Thomas Isaac Raines, Joshua H Garretson, Delaney Thurston, Rachel Patton McCord
Publikováno v:
EMBO reports. 23
To spread from a localized tumor, metastatic cancer cells must squeeze through constrictions that cause major nuclear deformations. Since chromosome structure affects nucleus stiffness, gene regulation, and DNA repair, here, we investigate the relati
Publikováno v:
Molecular cell. 82(12)
Chromosomes in higher eukaryotes are folded at different length scales into loop extrusion domains, spatial compartments, and chromosome territories and exhibit interactions with nuclear structures such as the lamina. Microscopic methods can probe th