Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Priyojit Das"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2240-2250 (2024)
The 3D conformations of chromosomes can encode biological significance, and the implications of such structures have been increasingly appreciated recently. Certain chromosome structural features, such as A/B compartmentalization, are frequently extr
Externí odkaz:
https://doaj.org/article/0c0697b30ae44fc49d46b7a871f4414d
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTChromatin regions that interact with the nuclear lamina are often heterochromatic, repressed in gene expression, and in the spatial B compartment. However, exceptions to this trend allow us to examine the relative impact of lamin association
Externí odkaz:
https://doaj.org/article/6d358b71f6d745559b64ec3951062b26
Autor:
Jacob T. Sanders, Rosela Golloshi, Priyojit Das, Yang Xu, Peyton H. Terry, Darrian G. Nash, Job Dekker, Rachel Patton McCord
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Layers of genome organization are becoming increasingly better characterized, but less is known about how these structures respond to perturbation or shape changes. Low-salt swelling of isolated chromatin fibers or nuclei has been used for d
Externí odkaz:
https://doaj.org/article/b467fe581014489d9d041d7c09c690ef
Publikováno v:
ACS Applied Materials & Interfaces; 10/30/2024, Vol. 16 Issue 43, p58689-58702, 14p
Publikováno v:
eLife, Vol 11 (2022)
The expression of a mutant Lamin A, progerin, in Hutchinson-Gilford Progeria Syndrome leads to alterations in genome architecture, nuclear morphology, epigenetic states, and altered phenotypes in all cells of the mesenchymal lineage. Here, we report
Externí odkaz:
https://doaj.org/article/93d35281d3b64f40b9d5391532696c92
Publikováno v:
ACS Applied Materials & Interfaces; October 2024, Vol. 16 Issue: 43 p58689-58702, 14p
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010392 (2022)
Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well unders
Externí odkaz:
https://doaj.org/article/f7febf0778b84278bf23c6e92d5e573d
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-28 (2020)
Abstract Background The nonrandom radial organization of eukaryotic chromosome territories (CTs) inside the nucleus plays an important role in nuclear functional compartmentalization. Increasingly, chromosome conformation capture (Hi-C) based approac
Externí odkaz:
https://doaj.org/article/78521c13a7334b769f09b403fe8cc4ff
Autor:
Rebeca San Martin, Priyojit Das, Tianchun Xue, Morgan Rose Brown, Renata Dos Reis Marques, Michael Essington, Adrian Gonzalez, Rachel Patton McCord
Publikováno v:
bioRxiv
Bone metastasis remains one of the biggest challenges in the treatment of prostate cancer, and other solid tumors such as breast, lung, and colon. Modeling a complex microenvironment in-vitro, such as the bone niche, requires interrogation of cell-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c021010df0fdd5879ec6495be5494c9
https://europepmc.org/articles/PMC10055203/
https://europepmc.org/articles/PMC10055203/
