Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Priyanka S. Rana"'
Autor:
Katarzyna Bialkowska, Lamyae El Khalki, Priyanka S. Rana, Wei Wang, Daniel J. Lindner, Yvonne Parker, Lucia R. Languino, Dario C. Altieri, Elzbieta Pluskota, Khalid Sossey-Alaoui, Edward F. Plow
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Kindlin-2 is a cytoskeletal adapter protein that is present in many different cell types. By virtue of its interaction with multiple binding partners, Kindlin-2 intercalates into numerous signaling pathways and cytoskeletal nodes. A specific
Externí odkaz:
https://doaj.org/article/5573cad98044439ab462d68666ca541d
Autor:
Ehsan Malek, Priyanka S. Rana, Muthulekha Swamydas, Michael Daunov, Masaru Miyagi, Elena Murphy, James J. Ignatz-Hoover, Leland Metheny, Seong Jin Kim, James J. Driscoll
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary end
Externí odkaz:
https://doaj.org/article/2986c29d1e41419b91ddff1528ad8605
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background Metastatic breast cancer is responsible for the death of the majority of breast cancer patients. In fact, metastatic BC is the 2nd leading cause of cancer-related deaths in women in the USA and worldwide. Triple negative breast ca
Externí odkaz:
https://doaj.org/article/5cbf0e2edd604380a38feea184a03c94
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Pathways that govern cellular bioenergetics are deregulated in tumor cells and represent a hallmark of cancer. Tumor cells have the capacity to reprogram pathways that control nutrient acquisition, anabolism and catabolism to enhance their growth and
Externí odkaz:
https://doaj.org/article/9c06a4f5c4cc4242b8cdc48875485fb0
Publikováno v:
Cancers, Vol 15, Iss 23, p 5632 (2023)
The majority of T-cell responses involve proteasome-dependent protein degradation and the downstream presentation of oligopeptide products complexed with major histocompatibility complex (MHC) class I (MHC-I) molecules to peptide-restricted CD8+ T-ce
Externí odkaz:
https://doaj.org/article/2afcd7f683cf4500b428e9bc496285ed
Publikováno v:
Cancers, Vol 15, Iss 19, p 4886 (2023)
Urothelial cell carcinoma (UCC, bladder cancer, BC) remains a difficult-to-treat malignancy with a rising incidence worldwide. In the U.S., UCC is the sixth most incident neoplasm and ~90% of diagnoses are made in those >55 years of age; it is ~four
Externí odkaz:
https://doaj.org/article/78079945bb624e70b71dc8e6854a2743
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Multiple myeloma (MM) remains a lethal hematologic cancer characterized by the expansion of transformed plasma cells within the permissive bone marrow (BM) milieu. The emergence of relapsed and/or refractory MM (RRMM) is provoked through clonal evolu
Externí odkaz:
https://doaj.org/article/657ac2031ff84ad584225c127a402a08
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A deeper understanding of basic immunology principles and advances in bioengineering have accelerated the mass production of genetically-reprogrammed T-cells as living drugs to treat human diseases. Autologous and allogeneic cytotoxic T-cells have be
Externí odkaz:
https://doaj.org/article/de1386d3dd10474c93908ed530cb3b96
Autor:
Priyanka S. Rana, Michael A. Model
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The standard theory of apoptotic volume decrease (AVD) posits activation of potassium and/or chloride channels, causing an efflux of ions and osmotic loss of water. However, in view of the multitude of possible channels that are known to support apop
Externí odkaz:
https://doaj.org/article/d1a0a1db7964452e8414d306edf8202f
Autor:
Wei Wang, Priyanka S. Rana, Akram Alkrekshi, Katarzyna Bialkowska, Vesna Markovic, William P. Schiemann, Edward F. Plow, Elzbieta Pluskota, Khalid Sossey-Alaoui
Publikováno v:
Cancers, Vol 14, Iss 3, p 639 (2022)
Breast cancer (BC) is one of the leading causes of cancer-related deaths due in part to its invasive and metastatic properties. Kindlin-2 (FERMT2) is associated with the pathogenesis of several cancers. Although the role of Kindlin-2 in regulating th
Externí odkaz:
https://doaj.org/article/2ec1541558a34f0da13ea8fea0f6edc2