Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Priyanka Ram"'
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
Samantha L. Payne, Priyanka Ram, Deepti H. Srinivasan, Thanh T. Le, Michael Levin, Madeleine J. Oudin
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103767- (2022)
Summary: Background: There is a critical need to better understand the mechanisms that drive local cell invasion and metastasis to develop new therapeutics targeting metastatic disease. Bioelectricity is an important mediator of cellular processes an
Externí odkaz:
https://doaj.org/article/e99afb0c39b94aadbd9b755b1014a55c
Autor:
Alison Crawford, Jessica R. Kirshner, Gavin Thurston, Eric Smith, Dangshe Ma, Jason T. Giurleo, Pamela Krueger, Sumreen Jalal, Jennifer Finney, Makenzie Danton, Priyanka Ram, Kristin Vazzana, Olulanu H. Aina, Lauric Haber, Richard Tavaré, Danica Chiu
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90be1b820eb9b214932b71972d26d15a
https://doi.org/10.1158/2326-6066.22543602.v1
https://doi.org/10.1158/2326-6066.22543602.v1
Autor:
Alison Crawford, Jessica R. Kirshner, Gavin Thurston, Eric Smith, Dangshe Ma, Jason T. Giurleo, Pamela Krueger, Sumreen Jalal, Jennifer Finney, Makenzie Danton, Priyanka Ram, Kristin Vazzana, Olulanu H. Aina, Lauric Haber, Richard Tavaré, Danica Chiu
Patients with hematologic cancers have improved outcomes after treatment with bispecific antibodies that bind to CD3 on T cells and that redirect T cells toward cancer cells. However, clinical benefit against solid tumors remains to be shown. We made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c35e7d21e92f6019bfca787dcc9c83
https://doi.org/10.1158/2326-6066.c.6550329.v1
https://doi.org/10.1158/2326-6066.c.6550329.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Verification of detection power calculation. Comparison between the predicted detection power of 18 replicates and the actual fraction of those replicates that were called MRD+. 18 independent samples from a 1:100k dilution were probed with a 488 SNV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64af9516783cfdb147d8e83ff11e720a
https://doi.org/10.1158/1078-0432.22478915.v1
https://doi.org/10.1158/1078-0432.22478915.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Early stage breast cancer cohort. (A) Overview of subtype distribution of cohort as well as the timing of blood draws relative to surgery and treatment. (B) REMARK diagram of the early stage breast cancer cohort. (C) Distribution of the number of mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a78d91244c2f15245d1f854b249187
https://doi.org/10.1158/1078-0432.22478927.v1
https://doi.org/10.1158/1078-0432.22478927.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Purpose:Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for tracking hundreds of patient-specific mutations to detect MRD with a 1,000-fold lower e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22733ab4686b715c65b3b05813aea31f
https://doi.org/10.1158/1078-0432.c.6530084
https://doi.org/10.1158/1078-0432.c.6530084
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Overview schematic of MRD assay. MRD assay workflow from characterizing a primary tumor to determining if a blood draw contains evidence of residual disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109f474d4909e0ad619512094777e084
https://doi.org/10.1158/1078-0432.22478924.v1
https://doi.org/10.1158/1078-0432.22478924.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Validation of tumor fraction confidence interval and effects of biological variability on tumor fraction inference. (A) Confidence intervals inferred from simulated data were aggregated into coverage probability for each condition and compared agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b046730e8f622b0bc9925a544e1dbd
https://doi.org/10.1158/1078-0432.22478912.v1
https://doi.org/10.1158/1078-0432.22478912.v1
Autor:
Viktor A. Adalsteinsson, Todd R. Golub, Erica L. Mayer, Ann H. Partridge, G. Mike Makrigiorgos, J. Christopher Love, Ian Krop, Nancy U. Lin, Matthew Meyerson, Eric P. Winer, Gad Getz, Atish D. Choudhury, Daniel G. Stover, Gavin Ha, Nikhil Wagle, Niall J. Lennon, Samuel S. Freeman, Matthew DeFelice, Donna S. Neuberg, Carrie Cibulskis, Lorenzo Trippa, Brendan Blumenstiel, Kathy D. Miller, Laura C. Collins, Shoshana M. Rosenberg, Melissa E. Hughes, Ka Wai Leong, Mariana Fitarelli-Kiehl, Fangyan Yu, Ofir Cohen, Denisse Rotem, Gregory J. Kirkner, Mark Fleharty, Tianyu Li, Christopher C. Lo, Kan Xiong, Pedro Exman, Priyanka Ram, Gregory Gydush, Sarah C. Reed, Justin Rhoades, Heather A. Parsons
Patients who experienced local recurrence only after treatment for early stage breast cancer. cfDNA time points for all patients who experienced local recurrence only. End points represent time of last follow up or death.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce06d96cad13d1e89573d2ff8a730a8
https://doi.org/10.1158/1078-0432.22478936.v1
https://doi.org/10.1158/1078-0432.22478936.v1