Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Priyanka Parijat"'
Autor:
Priyanka Parijat, Seetharamaiah Attili, Zoe Hoare, Michael Shattock, Victor Kenyon, Thomas Kampourakis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Direct modulation of cardiac myosin function has emerged as a therapeutic target for both heart disease and heart failure. However, the development of myosin-based therapeutics has been hampered by the lack of targeted in vitro screening ass
Externí odkaz:
https://doaj.org/article/fdb3305c07434d8c93e33d876a8dec58
Autor:
Priyanka Parijat, Saraswathi Ponnam, Seetharamaiah Attili, Kenneth S. Campbell, Mohammed El-Mezgueldi, Mark Pfuhl, Thomas Kampourakis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic an
Externí odkaz:
https://doaj.org/article/426170449f754cb48a52dcf44aedf251
Publikováno v:
FEBS Open Bio, Vol 8, Iss 10, Pp 1669-1690 (2018)
Mycobacterium tuberculosis (Mtb) is known to persist in extremely hostile environments within host macrophages. The ability to withstand such proteotoxic stress comes from its highly conserved molecular chaperone machinery. ClpB, a unique member of t
Externí odkaz:
https://doaj.org/article/915bb9c4739a4a288ef92b69bc81e01e
Publikováno v:
ACS Medicinal Chemistry Letters. 14:530-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb2e13ec5c2cd179d675bcbd56fc66f
https://doi.org/10.1021/acsmedchemlett.3c00033
https://doi.org/10.1021/acsmedchemlett.3c00033
Autor:
Laszlo Kondacs, Thomas Kampourakis, Alexander Alexandrovich, Mathias Gautel, Alexander J. A. Cobb, Priyanka Parijat
Publikováno v:
ACS chemical biology. 16(1)
Current therapeutic interventions for both heart disease and heart failure are largely insufficient and associated with undesired side effects. Biomedical research has emphasized the role of sarcomeric protein function for the normal performance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66103c2e9e020671aa64189e3815d5a6
https://pubmed.ncbi.nlm.nih.gov/33315370
https://pubmed.ncbi.nlm.nih.gov/33315370
Publikováno v:
FEBS Open Bio
Mycobacterium tuberculosis (Mtb) is known to persist in extremely hostile environments within host macrophages. The ability to withstand such proteotoxic stress comes from its highly conserved molecular chaperone machinery. ClpB, a unique member of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14a4a49a6a8c8ad3ce862a597be2ee4
http://europepmc.org/articles/PMC6168691
http://europepmc.org/articles/PMC6168691
Publikováno v:
Biochimie. 168
Molecular chaperones are a conserved family of proteins that are over-expressed in response to heat and other stresses. The regulation of expression of chaperone proteins plays a vital role in pathogenesis of various bacterial pathogens. In M. tuberc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d56b586acedcc197cf2d38a8e2d42e
https://pubmed.ncbi.nlm.nih.gov/31765672
https://pubmed.ncbi.nlm.nih.gov/31765672
Publikováno v:
Biophysical Journal. 116:386a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d077fedc0d893a7a38716668dc56068
https://doi.org/10.1016/j.bpj.2018.11.2090
https://doi.org/10.1016/j.bpj.2018.11.2090
Autor:
Priyanka, Parijat, Janendra K, Batra
Publikováno v:
IUBMB life. 67(11)
Heat shock proteins (Hsps) are a highly conserved family of proteins. The regulation of expression of Hsps in Mycobacterium tuberculosis, is regulated both positively and negatively by alternate sigma factors and transcriptional DNA repressors, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::308058c1d9465a9c39769af211991926
https://pubmed.ncbi.nlm.nih.gov/26442450
https://pubmed.ncbi.nlm.nih.gov/26442450