Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers

Autor: Mayuri Inchanalkar, Sumana Srivatsa, Srikant Ambatipudi, Priyanka G. Bhosale, Asawari Patil, Alejandro A. Schäffer, Niko Beerenwinkel, Manoj B. Mahimkar

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)

Abstract Background Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genomic drivers in OSCC, b

Externí odkaz: https://doaj.org/article/68e3d9c0391a4ad49e33391560a83b9e

Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer

Autor: Simona Cristea, Manoj B. Mahimkar, Shubhada Kane, Anita M. Borges, Niko Beerenwinkel, Srikant Ambatipudi, Asawari Patil, Rajiv S. Desai, Rajiv Kumar, Priyanka G. Bhosale, Alejandro A. Schäffer

Publikováno v: Translational Oncology, Vol 10, Iss 3, Pp 396-409 (2017)
Translational Oncology
Bhosale, P G, Cristea, S, Ambatipudi, S, Desai, R S, Kumar, R, Patil, A, Kane, S, Borges, A M, Schäffer, A A, Beerenwinkel, N & Mahimkar, M B 2017, ' Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer ', Translational Oncology, vol. 10, no. 3, pp. 396-409 . https://doi.org/10.1016/j.tranon.2017.03.008
TRANSLATIONAL ONCOLOGY, 10 (3)

We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa725ddad79b30af7243ea07e91bb6
http://www.sciencedirect.com/science/article/pii/S193652331730075X

Detection of HPV E6/E7 mRNA in Clinical Samples Using RNA In Situ Hybridization

Autor: Manoj B. Mahimkar, Manishkumar Pandey, Priyanka G. Bhosale

Publikováno v: Methods in Molecular Biology ISBN: 9781493975648

Detection of human papilloma virus (HPV) in tissue specimens has been a clinical challenge since last 2 decades; however, screening for presence of E6/E7 transcripts is regarded as the gold standard, and it verifies the active HPV infection. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f1dbc809eda3a466cf522515db20bed
https://doi.org/10.1007/978-1-4939-7565-5_15

Low prevalence of transcriptionally active human papilloma virus in Indian patients with HNSCC and leukoplakia

Autor: Shubhada Kane, Manishkumar Pandey, Asawari Patil, Kumar Prabhash, Rajiv S. Desai, Priyanka G. Bhosale, Manoj B. Mahimkar

Publikováno v: Oral surgery, oral medicine, oral pathology and oral radiology. 122(5)

Objectives In the present study, we comprehensively analyzed the prevalence of transcriptionally active human papilloma virus (HPV) in tissue samples of Indian patients with leukoplakia, predominantly hyperplastic lesions and head and neck squamous c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c657b35386f510089b9c3085ca872170
https://pubmed.ncbi.nlm.nih.gov/27765330

Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer

Autor: Priyanka G. Bhosale, Simona Cristea, Srikant Ambatipudi, Rajiv S. Desai, Rajiv Kumar, Asawari Patil, Shubhada Kane, Anita M. Borges, Alejandro A. Schäffer, Niko Beerenwinkel, Manoj B. Mahimkar

Publikováno v: Translational Oncology, Vol 10, Iss 3, Pp 396-409 (2017)

We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profile

Externí odkaz: https://doaj.org/article/ec5a4b7c32bf4a798cb6873927397eaf