Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Priyanka Dhingra"'
Autor:
Alyssa D Fronk, Miguel A Manzanares, Paulina Zheng, Adam Geier, Kendall Anderson, Shaleigh Stanton, Hasan Zumrut, Sakshi Gera, Robin Munch, Vanessa Frederick, Priyanka Dhingra, Gayatri Arun, Martin Akerman
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 676-701 (2024)
Abstract Splice-switching oligonucleotides (SSOs) are antisense compounds that act directly on pre-mRNA to modulate alternative splicing (AS). This study demonstrates the value that artificial intelligence/machine learning (AI/ML) provides for the id
Externí odkaz:
https://doaj.org/article/af0776e556f747fd855724c15473a6ed
Autor:
John Dodd, Robert Jordan, Marie Makhlina, Keith Barnett, Ad Roffel, Carl Spana, Alison Obr, Priyanka Dhingra, Paul S. Kayne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel, polymer-enc
Externí odkaz:
https://doaj.org/article/6822292f0ed94f7caf82349ccec80548
Autor:
Matthew A. Reyna, David Haan, Marta Paczkowska, Lieven P. C. Verbeke, Miguel Vazquez, Abdullah Kahraman, Sergio Pulido-Tamayo, Jonathan Barenboim, Lina Wadi, Priyanka Dhingra, Raunak Shrestha, Gad Getz, Michael S. Lawrence, Jakob Skou Pedersen, Mark A. Rubin, David A. Wheeler, Søren Brunak, Jose M. G. Izarzugaza, Ekta Khurana, Kathleen Marchal, Christian von Mering, S. Cenk Sahinalp, Alfonso Valencia, PCAWG Drivers and Functional Interpretation Working Group, Jüri Reimand, Joshua M. Stuart, Benjamin J. Raphael, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analys
Externí odkaz:
https://doaj.org/article/d9995364c8fb4afc89d4bb8a8bc2379d
Autor:
Matthew A. Reyna, David Haan, Marta Paczkowska, Lieven P. C. Verbeke, Miguel Vazquez, Abdullah Kahraman, Sergio Pulido-Tamayo, Jonathan Barenboim, Lina Wadi, Priyanka Dhingra, Raunak Shrestha, Gad Getz, Michael S. Lawrence, Jakob Skou Pedersen, Mark A. Rubin, David A. Wheeler, Søren Brunak, Jose M. G. Izarzugaza, Ekta Khurana, Kathleen Marchal, Christian von Mering, S. Cenk Sahinalp, Alfonso Valencia, PCAWG Drivers and Functional Interpretation Working Group, Jüri Reimand, Joshua M. Stuart, Benjamin J. Raphael, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/2e68c62b177945e9b33b29c835967c66
Autor:
Priyanka Dhingra, Alexander Martinez-Fundichely, Adeline Berger, Franklin W. Huang, Andre Neil Forbes, Eric Minwei Liu, Deli Liu, Andrea Sboner, Pablo Tamayo, David S. Rickman, Mark A. Rubin, Ekta Khurana
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-23 (2017)
Abstract We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding and non-coding single nucleotide variants, structural variants, and DNA methylation changes in the DNase I hypersensit
Externí odkaz:
https://doaj.org/article/7d6a18d3f0444aceadbe8d4b57bb15bb
Autor:
Alessandro Romanel, Sonia Garritano, Blerta Stringa, Mirjam Blattner, Davide Dalfovo, Dimple Chakravarty, David Soong, Kellie A. Cotter, Gianluca Petris, Priyanka Dhingra, Paola Gasperini, Anna Cereseto, Olivier Elemento, Andrea Sboner, Ekta Khurana, Alberto Inga, Mark A. Rubin, Francesca Demichelis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone depe
Externí odkaz:
https://doaj.org/article/9c76b74b1a9c4adba882a4b50f1bdddc
Publikováno v:
Materials Today: Proceedings. 80:18-23
Autor:
Miguel A Manzanares, Priyanka Dhingra, Kendall Anderson, Vanessa Frederick, Adam Geier, Alyssa Casill, Martin Akerman, Gayatri Arun
Publikováno v:
Cancer Research. 82:P5-17
Aberrant splicing is a major hallmark of cancer, affecting tumor progression, metastasis, and therapy resistance. The oncogenic activity of specific cis splicing errors and trans-acting splicing factor misregulation in patient tumors have been demons
Autor:
Priyanka Dhingra, Shashank Sharma, Vikas Bhardwaj, Anila Dhingra, Yogita Madan, Divya Bajpai Tripathy, Anjali Gupta
Publikováno v:
Polymeric Biomaterials ISBN: 9781003240884
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9009353b3a520f9b74824136e9c8296f
https://doi.org/10.1201/9781003240884-8
https://doi.org/10.1201/9781003240884-8
Autor:
Alyssa D Fronk, Miguel A Manzanares, Paulina Zheng, Adam Geier, Kendall Anderson, Vanessa Frederick, Shaleigh Smith, Sakshi Gera, Robin Munch, Mahati Are, Priyanka Dhingra, Gayatri Arun, Martin Akerman
This study demonstrates the value that artificial intelligence/machine learning (AI/ML) provides for the identification of novel and verifiable splice-switching oligonucleotide (SSO) targetsin-silico. SSOs are antisense compounds that act directly on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b9bcb7d19b234dfd363b5fc824d646
https://doi.org/10.1101/2022.10.14.512313
https://doi.org/10.1101/2022.10.14.512313