Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Priyadharshini Devarajan"'
Autor:
Priyadharshini Devarajan, Allen M. Vong, Catherine H. Castonguay, Noah J. Silverstein, Olivia Kugler-Umana, Bianca L. Bautista, Karen A. Kelly, Jeremy Luban, Susan L. Swain
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113429- (2023)
Externí odkaz:
https://doaj.org/article/370f4f484e794576b3fda940ba2c76b5
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/0fec9961ffaa4b08962383083e06ba54
Autor:
Priyadharshini Devarajan, Michael C. Jones, Olivia Kugler-Umana, Allen M. Vong, Jingya Xia, Susan L. Swain
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Although much is known about the mechanisms by which pathogen recognition drives the initiation of T cell responses, including those to respiratory viruses, the role of pathogen recognition in fate decisions of T cells once they have become effectors
Externí odkaz:
https://doaj.org/article/94f01bb1f2b24378aa6b61f63e808112
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 574-585 (2015)
CD4 and CD8 T cell lineages differentiate through respective thymic selection processes. Here, we report cross-differentiation from the CD8 lineage to CD4 T cells, but not vice versa, predominantly in the large-intestine-associated microenvironment.
Externí odkaz:
https://doaj.org/article/cf145ae0a0774adfab3aa6e940c289c5
Autor:
Michael C. Jones, Catherine Castonguay, Padma P. Nanaware, Grant C. Weaver, Brian Stadinski, Olivia A. Kugler-Umana, Eric S. Huseby, Lawrence J. Stern, Karl Kai McKinstry, Tara M. Strutt, Priyadharshini Devarajan, Susan L. Swain
Publikováno v:
The Journal of Immunology.
Initial TCR affinity for peptide Ag is known to impact the generation of memory; however, its contributions later, when effectors must again recognize Ag at 5–8 d postinfection to become memory, is unclear. We examined whether the effector TCR affi
Autor:
Kunal Dhume, Caroline M. Finn, Priyadharshini Devarajan, Ayushi Singh, Joanne D. Tejero, Emily Prokop, Tara M. Strutt, Stewart Sell, Susan L. Swain, Karl Kai McKinstry
Publikováno v:
J Immunol
Optimal transcriptional programming needed for CD4 T cells to protect against influenza A virus (IAV) is unclear. Most IAV-primed CD4 T cells fit Th1 criteria. However, cells deficient for the Th1 “master regulator,” T-bet, although marked by red
Autor:
Olivia Kugler‐Umana, Wenliang Zhang, Yi Kuang, Jialing Liang, Catherine H. Castonguay, Susan L. Tonkonogy, Ann Marshak‐Rothstein, Priyadharshini Devarajan, Susan L. Swain
Publikováno v:
Aging Cell. 21
Autor:
Olivia, Kugler-Umana, Wenliang, Zhang, Yi, Kuang, Jialing, Liang, Catherine H, Castonguay, Susan L, Tonkonogy, Ann, Marshak-Rothstein, Priyadharshini, Devarajan, Susan L, Swain
Publikováno v:
Aging cell. 21(10)
Age-associated B cells (ABC) accumulate with age and are associated with autoimmunity and chronic infection. However, their contributions to acute infection in the aged and their developmental pathways are unclear. We find that the response against i
Autor:
Michael C. Jones, Catherine Castonguay, Padma P. Nanaware, Grant C. Weaver, Brian Stadinski, Olivia A. Kugler-Umana, Eric Huseby, Lawrence J. Stern, Priyadharshini Devarajan, Susan L. Swain
The impact of initial peptide antigen affinity for TCR in driving memory fate has been studied previously, however its contributions when effectors contract to memory is unclear. To become memory, effector CD4 T cells must recognize antigen at 5-8 da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6634c0c50ff900a9b79c70a5e7bba2
https://doi.org/10.1101/2022.05.09.491158
https://doi.org/10.1101/2022.05.09.491158
Autor:
Priyadharshini Devarajan, Allen M. Vong, Catherine H. Castonguay, Olivia Kugler-Umana, Bianca L. Bautista, Michael C. Jones, Karen A. Kelly, Jingya Xia, Susan L. Swain
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Influenza infection elicits strong, long-lived protective antibodies, but most current influenza vaccines give weaker, short-lived protection. We noted that live virus is still replicating, making antigen and causing inflammation at 7 d